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    Results: 1 to 20 of 94

    1.

    Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.

    Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ.

    Mol Neurodegener. 2009 May 6;4:19.

    PMID:
    19419556
    [PubMed - in process]
    Free PMC Article
    2.

    Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

    Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F.

    J Neurosci. 2002 May 1;22(9):3445-53.

    PMID:
    11978821
    [PubMed - indexed for MEDLINE]
    Free Article
    3.

    Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.

    Barten DM, Guss VL, Corsa JA, Loo A, Hansel SB, Zheng M, Munoz B, Srinivasan K, Wang B, Robertson BJ, Polson CT, Wang J, Roberts SB, Hendrick JP, Anderson JJ, Loy JK, Denton R, Verdoorn TA, Smith DW, Felsenstein KM.

    J Pharmacol Exp Ther. 2005 Feb;312(2):635-43. Epub 2004 Sep 27.

    PMID:
    15452193
    [PubMed - indexed for MEDLINE]
    Free Article
    4.

    Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

    Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

    J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. Epub 2009 Aug 11.

    PMID:
    19671883
    [PubMed - indexed for MEDLINE]
    Free Article
    5.

    Commentary: Abeta N- Terminal Isoforms: Critical contributors in the course of AD pathophysiology.

    Tekirian TL.

    J Alzheimers Dis. 2001 Apr;3(2):241-248.

    PMID:
    12214065
    [PubMed - as supplied by publisher]
    6.

    [Alzheimer disease: cellular and molecular aspects].

    Octave JN.

    Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.

    PMID:
    16768248
    [PubMed - indexed for MEDLINE]
    7.

    Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.

    Abramowski D, Wiederhold KH, Furrer U, Jaton AL, Neuenschwander A, Runser MJ, Danner S, Reichwald J, Ammaturo D, Staab D, Stoeckli M, Rueeger H, Neumann U, Staufenbiel M.

    J Pharmacol Exp Ther. 2008 Nov;327(2):411-24. Epub 2008 Aug 7.

    PMID:
    18687920
    [PubMed - indexed for MEDLINE]
    Free Article
    8.

    Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice.

    Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee JM.

    J Neurosci. 2009 Aug 26;29(34):10706-14.

    PMID:
    19710322
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    9.

    Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.

    Jaffar S, Counts SE, Ma SY, Dadko E, Gordon MN, Morgan D, Mufson EJ.

    Exp Neurol. 2001 Aug;170(2):227-43.

    PMID:
    11476589
    [PubMed - indexed for MEDLINE]
    10.

    Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice.

    Garcia-Alloza M, Borrelli LA, Hyman BT, Bacskai BJ.

    Neurobiol Aging. 2010 Dec;31(12):2058-68. Epub 2009 Jan 4.

    PMID:
    19124175
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    11.

    Detection of neuritic plaques in Alzheimer's disease mouse model.

    Ly PT, Cai F, Song W.

    J Vis Exp. 2011 Jul 26;(53). pii: 2831. doi: 10.3791/2831.

    PMID:
    21841757
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    12.

    Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase.

    Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N.

    J Biol Chem. 2008 Jun 20;283(25):17721-30. Epub 2008 Apr 23.

    PMID:
    18436531
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    13.

    Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

    Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

    J Neurosci. 2005 Jul 20;25(29):6755-64.

    PMID:
    16033885
    [PubMed - indexed for MEDLINE]
    Free Article
    14.

    Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice.

    Lee JW, Lee YK, Ban JO, Ha TY, Yun YP, Han SB, Oh KW, Hong JT.

    J Nutr. 2009 Oct;139(10):1987-93. Epub 2009 Aug 5.

    PMID:
    19656855
    [PubMed - indexed for MEDLINE]
    Free Article
    15.

    Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology.

    Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT.

    Brain. 2010 May;133(Pt 5):1312-27. Epub 2010 Mar 31.

    PMID:
    20360050
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    16.

    Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.

    Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM.

    J Biol Chem. 2004 Mar 26;279(13):12876-82. Epub 2004 Jan 6.

    PMID:
    14709552
    [PubMed - indexed for MEDLINE]
    Free Article
    18.

    Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.

    Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM.

    J Clin Invest. 2005 Feb;115(2):428-33.

    PMID:
    15668737
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    19.

    Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease.

    Van Broeck B, Chen JM, Tréton G, Desmidt M, Hopf C, Ramsden N, Karran E, Mercken M, Rowley A.

    Br J Pharmacol. 2011 May;163(2):375-89. doi: 10.1111/j.1476-5381.2011.01207.x.

    PMID:
    21232036
    [PubMed - indexed for MEDLINE]
    20.

    Identification of gamma-secretase inhibitor potency determinants on presenilin.

    Zhao B, Yu M, Neitzel M, Marugg J, Jagodzinski J, Lee M, Hu K, Schenk D, Yednock T, Basi G.

    J Biol Chem. 2008 Feb 1;283(5):2927-38. Epub 2007 Nov 21.

    PMID:
    18032377
    [PubMed - indexed for MEDLINE]
    Free Article

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