PubMed

Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

Diabetes. 2009 May;58(5):1067-76. Erratum in: Diabetes. 2009 Jul;58(7):1721. PMID: 19401434 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of GPR40 in Pancreatic {beta}-Cells Augments Glucose Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice.

Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

Diabetes. 2009 Feb 19. [Epub ahead of print]PMID: 19208915 [PubMed - as supplied by publisher]Related articles

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.

Tan CP, Feng Y, Zhou YP, Eiermann GJ, Petrov A, Zhou C, Lin S, Salituro G, Meinke P, Mosley R, Akiyama TE, Einstein M, Kumar S, Berger JP, Mills SG, Thornberry NA, Yang L, Howard AD.

Diabetes. 2008 Aug;57(8):2211-9. Epub 2008 May 13.PMID: 18477808 [PubMed - indexed for MEDLINE]Related articlesFree article

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V.

Diabetes. 2008 Sep;57(9):2432-7. Epub 2008 Jun 16. Erratum in: Diabetes. 2008 Nov;57(11):3166. PMID: 18559658 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.

Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N.

Mol Med. 1999 Mar;5(3):169-80.PMID: 10404514 [PubMed - indexed for MEDLINE]Related articlesFree article

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V.

Diabetes. 2007 Apr;56(4):1087-94.PMID: 17395749 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat.

Doshi LS, Brahma MK, Sayyed SG, Dixit AV, Chandak PG, Pamidiboina V, Motiwala HF, Sharma SD, Nemmani KV.

Metabolism. 2009 Mar;58(3):333-43.PMID: 19217448 [PubMed - indexed for MEDLINE]Related articles

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.

J Clin Invest. 2000 Mar;105(6):731-40.PMID: 10727441 [PubMed - indexed for MEDLINE]Related articlesFree article

Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.

Edfalk S, Steneberg P, Edlund H.

Diabetes. 2008 Sep;57(9):2280-7. Epub 2008 Jun 2.PMID: 18519800 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice.

Ahrén B, Simonsson E, Scheurink AJ, Mulder H, Myrsén U, Sundler F.

Metabolism. 1997 Jan;46(1):97-106.PMID: 9005977 [PubMed - indexed for MEDLINE]Related articles

Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.

Yamamoto K, Hashimoto H, Tomimoto S, Shintani N, Miyazaki J, Tashiro F, Aihara H, Nammo T, Li M, Yamagata K, Miyagawa J, Matsuzawa Y, Kawabata Y, Fukuyama Y, Koga K, Mori W, Tanaka K, Matsuda T, Baba A.

Diabetes. 2003 May;52(5):1155-62.PMID: 12716746 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.

Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S.

Br J Pharmacol. 2006 Jul;148(5):619-28. Epub 2006 May 15.PMID: 16702987 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

Schnell S, Schaefer M, Schöfl C.

Mol Cell Endocrinol. 2007 Jan 15;263(1-2):173-80. Epub 2006 Nov 13.PMID: 17101212 [PubMed - indexed for MEDLINE]Related articles

Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis.

Devedjian JC, Pujol A, Cayla C, George M, Casellas A, Paris H, Bosch F.

Diabetologia. 2000 Jul;43(7):899-906.PMID: 10952463 [PubMed - indexed for MEDLINE]Related articles

STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

Jackerott M, Møldrup A, Thams P, Galsgaard ED, Knudsen J, Lee YC, Nielsen JH.

Diabetes. 2006 Oct;55(10):2705-12.PMID: 17003334 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of yeast hexokinase in pancreatic beta cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes.

Epstein PN, Boschero AC, Atwater I, Cai X, Overbeek PA.

Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12038-42.PMID: 1465437 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic sympathetic innervation of islets in transgenic mice results in differential desensitization of alpha-adrenergic inhibition of insulin secretion.

Grodsky GM, Ma YH, Edwards RH.

Adv Exp Med Biol. 1997;426:129-38.PMID: 9544265 [PubMed - indexed for MEDLINE]Related articles

Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.

Iwakura H, Hosoda K, Son C, Fujikura J, Tomita T, Noguchi M, Ariyasu H, Takaya K, Masuzaki H, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Itoh H, Toyokuni S, Kangawa K, Nakao K.

J Biol Chem. 2005 Apr 15;280(15):15247-56. Epub 2005 Feb 8.PMID: 15701644 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo.

Kato I, Suzuki Y, Akabane A, Yonekura H, Tanaka O, Kondo H, Takasawa S, Yoshimoto T, Okamoto H.

J Biol Chem. 1994 Aug 19;269(33):21223-8.PMID: 8063743 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice.

Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, Ferrara N, Gerber H, Kawamori R, Inoue M, Watada H.

Diabetologia. 2007 Feb;50(2):380-9. Epub 2006 Dec 16.PMID: 17180351 [PubMed - indexed for MEDLINE]Related articles