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    Results: 1 to 20 of 90

    1.

    GPR40: good cop, bad cop?

    Alquier T, Poitout V.

    Diabetes. 2009 May;58(5):1035-6. No abstract available. PMID: 19401432 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

    Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

    Diabetes. 2009 May;58(5):1067-76. Erratum in: Diabetes. 2009 Jul;58(7):1721. PMID: 19401434 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

    Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V.

    Diabetes. 2007 Apr;56(4):1087-94.PMID: 17395749 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1.

    Zhang Y, Xu M, Zhang S, Yan L, Yang C, Lu W, Li Y, Cheng H.

    J Mol Endocrinol. 2007 Jun;38(6):651-61.PMID: 17556534 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.

    Chu ZL, Jones RM, He H, Carroll C, Gutierrez V, Lucman A, Moloney M, Gao H, Mondala H, Bagnol D, Unett D, Liang Y, Demarest K, Semple G, Behan DP, Leonard J.

    Endocrinology. 2007 Jun;148(6):2601-9. Epub 2007 Feb 8. Erratum in: Endocrinology. 2007 Oct;148(10):4753. PMID: 17289847 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

    Schnell S, Schaefer M, Schöfl C.

    Mol Cell Endocrinol. 2007 Jan 15;263(1-2):173-80. Epub 2006 Nov 13.PMID: 17101212 [PubMed - indexed for MEDLINE]Related articles

    7.

    Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.

    Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S.

    Br J Pharmacol. 2006 Jul;148(5):619-28. Epub 2006 May 15.PMID: 16702987 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.

    Vettor R, Granzotto M, De Stefani D, Trevellin E, Rossato M, Farina MG, Milan G, Pilon C, Nigro A, Federspil G, Vigneri R, Vitiello L, Rizzuto R, Baratta R, Frittitta L.

    J Clin Endocrinol Metab. 2008 Sep;93(9):3541-50. Epub 2008 Jun 26.PMID: 18583466 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.

    Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, Lucman A, Pedraza M, Mondala H, Gao H, Bagnol D, Chen R, Jones RM, Behan DP, Leonard J.

    Endocrinology. 2008 May;149(5):2038-47. Epub 2008 Jan 17.PMID: 18202141 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.

    Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H.

    Cell Metab. 2005 Apr;1(4):245-58.PMID: 16054069 [PubMed - indexed for MEDLINE]Related articles

    11.

    Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

    Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shinohara T, Hinuma S, Fujisawa Y, Fujino M.

    Nature. 2003 Mar 13;422(6928):173-6. Epub 2003 Feb 23.PMID: 12629551 [PubMed - indexed for MEDLINE]Related articles

    12.

    The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice.

    Brownlie R, Mayers RM, Pierce JA, Marley AE, Smith DM.

    Biochem Soc Trans. 2008 Oct;36(Pt 5):950-4. Review.PMID: 18793167 [PubMed - indexed for MEDLINE]Related articles

    13.

    A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.

    Gautam D, Han SJ, Hamdan FF, Jeon J, Li B, Li JH, Cui Y, Mears D, Lu H, Deng C, Heard T, Wess J.

    Cell Metab. 2006 Jun;3(6):449-61.PMID: 16753580 [PubMed - indexed for MEDLINE]Related articles

    14.

    Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice.

    Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, Ferrara N, Gerber H, Kawamori R, Inoue M, Watada H.

    Diabetologia. 2007 Feb;50(2):380-9. Epub 2006 Dec 16.PMID: 17180351 [PubMed - indexed for MEDLINE]Related articles

    15.

    Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells.

    Spurlin BA, Thurmond DC.

    Mol Endocrinol. 2006 Jan;20(1):183-93. Epub 2005 Aug 11.PMID: 16099818 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat.

    Doshi LS, Brahma MK, Sayyed SG, Dixit AV, Chandak PG, Pamidiboina V, Motiwala HF, Sharma SD, Nemmani KV.

    Metabolism. 2009 Mar;58(3):333-43.PMID: 19217448 [PubMed - indexed for MEDLINE]Related articles

    17.

    Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists.

    Song F, Lu S, Gunnet J, Xu JZ, Wines P, Proost J, Liang Y, Baumann C, Lenhard J, Murray WV, Demarest KT, Kuo GH.

    J Med Chem. 2007 Jun 14;50(12):2807-17. Epub 2007 May 15.PMID: 17500511 [PubMed - indexed for MEDLINE]Related articles

    18.

    Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.

    Tomita T, Masuzaki H, Iwakura H, Fujikura J, Noguchi M, Tanaka T, Ebihara K, Kawamura J, Komoto I, Kawaguchi Y, Fujimoto K, Doi R, Shimada Y, Hosoda K, Imamura M, Nakao K.

    Diabetologia. 2006 May;49(5):962-8. Epub 2006 Mar 9.PMID: 16525841 [PubMed - indexed for MEDLINE]Related articles

    19.

    Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.

    Mårtensson UE, Salehi SA, Windahl S, Gomez MF, Swärd K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, Grände PO, Owman C, Rosen CJ, Adamo ML, Lundquist I, Rorsman P, Nilsson BO, Ohlsson C, Olde B, Leeb-Lundberg LM.

    Endocrinology. 2009 Feb;150(2):687-98. Epub 2008 Oct 9.PMID: 18845638 [PubMed - indexed for MEDLINE]Related articles

    20.

    Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism.

    Santos SH, Fernandes LR, Mario EG, Ferreira AV, Pôrto LC, Alvarez-Leite JI, Botion LM, Bader M, Alenina N, Santos RA.

    Diabetes. 2008 Feb;57(2):340-7. Epub 2007 Nov 19.PMID: 18025412 [PubMed - indexed for MEDLINE]Related articlesFree article

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