PubMed

Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression.

Tchorsh-Yutsis D, Hecht G, Aronovich A, Shezen E, Klionsky Y, Rosen C, Bitcover R, Eventov-Friedman S, Katchman H, Cohen S, Tal O, Milstein O, Yagita H, Blazar BR, Reisner Y.

Diabetes. 2009 Jul;58(7):1585-94. Epub 2009 Apr 28.PMID: 19401429 [PubMed - indexed for MEDLINE]Related articlesFree article

Embryonic pig pancreatic tissue transplantation for the treatment of diabetes.

Eventov-Friedman S, Tchorsh D, Katchman H, Shezen E, Aronovich A, Hecht G, Dekel B, Rechavi G, Blazar BR, Feine I, Tal O, Freud E, Reisner Y.

PLoS Med. 2006 Jul;3(7):e215.PMID: 16768546 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats.

Maeda A, Goto M, Zhang J, Bennet W, Groth CG, Korsgren O, Wennberg L.

Transplantation. 2003 Apr 27;75(8):1409-14.PMID: 12717240 [PubMed - indexed for MEDLINE]Related articles

Induction of operational tolerance to discordant dopaminergic porcine xenografts.

Larsson LC, Corbascio M, Pearson TC, Larsen CP, Ekberg H, Widner H.

Transplantation. 2003 May 15;75(9):1448-54.PMID: 12792495 [PubMed - indexed for MEDLINE]Related articles

Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model.

Hecht G, Eventov-Friedman S, Rosen C, Shezen E, Tchorsh D, Aronovich A, Freud E, Golan H, El-Hasid R, Katchman H, Hering BJ, Zung A, Kra-Oz Z, Shaked-Mishan P, Yusim A, Shtabsky A, Idelevitch P, Tobar A, Harmelin A, Bachar-Lustig E, Reisner Y.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8659-64. Epub 2009 May 11.PMID: 19433788 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response.

Koulmanda M, Laufer TM, Auchincloss H Jr, Smith RN.

Xenotransplantation. 2004 Nov;11(6):525-30.PMID: 15479462 [PubMed - indexed for MEDLINE]Related articles

Lewis rat pancreas, but not cardiac xenografts, are resistant to anti-gal antibody mediated hyperacute rejection.

Yin DP, Sankary HN, Ma LL, Shen J, Qin Y, Blinder L, Williams JW, Chong AS.

Transplantation. 2001 May 27;71(10):1385-9.PMID: 11391223 [PubMed - indexed for MEDLINE]Related articles

Anti-LFA-1 improves pig islet xenograft function in diabetic mice when long-term acceptance is induced by CTLA4Ig/anti-CD40L.

Kumagai-Braesch M, Ekberg H, Wang F, Osterholm C, Ehrnfelt C, Sharma A, Lindeborg E, Holgersson J, Corbascio M.

Transplantation. 2007 May 15;83(9):1259-67.PMID: 17496544 [PubMed - indexed for MEDLINE]Related articles

Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1,3-galactosyltransferase knockout (GT-Ko) mice.

Chong AS, Ma L, Yin D, Shen J, Blinder L, XiuLong X, Williams JW, Byrne G, Diamond LE, Logan JS.

Xenotransplantation. 2000 Nov;7(4):275-83.PMID: 11081762 [PubMed - indexed for MEDLINE]Related articles

Role of double-negative regulatory T cells in long-term cardiac xenograft survival.

Chen W, Ford MS, Young KJ, Cybulsky MI, Zhang L.

J Immunol. 2003 Feb 15;170(4):1846-53.PMID: 12574350 [PubMed - indexed for MEDLINE]Related articlesFree article

The critical role of mouse CD4+ cells in the rejection of highly disparate xenogeneic pig thymus grafts.

Zhao Y, Swenson K, Wekerle T, Rodriguez-Barbosa JI, Arn JS, Sykes M.

Xenotransplantation. 2000 May;7(2):129-37.PMID: 10961297 [PubMed - indexed for MEDLINE]Related articles

Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice.

Sarnacki S, Auber F, Crétolle C, Camby C, Cavazzana-Calvo M, Müller W, Wagner N, Brousse N, Révillon Y, Fischer A, Cerf-Bensussan N.

Gut. 2000 Jul;47(1):97-104.PMID: 10861270 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of intestinal allograft rejection by FTY720 and costimulation blockade.

Yan S, Rodriguez-Barbosa JI, Pabst O, Beckmann JH, Brinkmann V, Förster R, Hoffmann MW.

Transplant Proc. 2005 Jan-Feb;37(1):114-5.PMID: 15808565 [PubMed - indexed for MEDLINE]Related articles

Long-term survival of rat to mouse cardiac xenografts with prolonged blockade of CD28-B7 interaction combined with peritransplant T-cell depletion.

Rehman A, Tu Y, Arima T, Linsley PS, Flye MW.

Surgery. 1996 Aug;120(2):205-12.PMID: 8751584 [PubMed - indexed for MEDLINE]Related articles

Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts.

Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Gray GS, Vallera DA.

Blood. 1995 May 1;85(9):2607-18.PMID: 7537122 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunotherapy with nondepleting anti-CD4 monoclonal antibodies but not CD28 antagonists protects islet graft in spontaneously diabetic nod mice from autoimmune destruction and allogeneic and xenogeneic graft rejection.

Guo Z, Wu T, Kirchhof N, Mital D, Williams JW, Azuma M, Sutherland DE, Hering BJ.

Transplantation. 2001 Jun 15;71(11):1656-65.PMID: 11435979 [PubMed - indexed for MEDLINE]Related articles

Anti-CD4 monoclonal antibody treatment combined with total lymphoid irradiation and cyclosporin A in hamster-to-rat cardiac transplantation. Analysis of lymphocyte subsets and anti-donor xenoantibodies.

Steinbrüchel DA, Madsen HH, Lillevang S, Nielsen B, Kemp E.

Transpl Immunol. 1993;1(3):209-16.PMID: 7915954 [PubMed - indexed for MEDLINE]Related articles

Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720.

Fu F, Hu S, Deleo J, Li S, Hopf C, Hoover J, Wang S, Brinkmann V, Lake P, Shi VC.

Transplantation. 2002 May 15;73(9):1425-30.PMID: 12023620 [PubMed - indexed for MEDLINE]Related articles

Simultaneous inhibition of B7 and LFA-1 signaling prevents rejection of discordant neural xenografts in mice lacking CD40L.

Larsson LC, Corbascio M, Widner H, Pearson TC, Larsen CP, Ekberg H.

Xenotransplantation. 2002 Jan;9(1):68-76.PMID: 12005106 [PubMed - indexed for MEDLINE]Related articles

Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis.

Shimizu K, Schönbeck U, Mach F, Libby P, Mitchell RN.

J Immunol. 2000 Sep 15;165(6):3506-18.PMID: 10975872 [PubMed - indexed for MEDLINE]Related articlesFree article