PubMed

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

Diabetes. 2009 Jul;58(7):1499-508. Epub 2009 Apr 14.PMID: 19366863 [PubMed - indexed for MEDLINE]Related articlesFree article

Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice.

Burgess SC, Leone TC, Wende AR, Croce MA, Chen Z, Sherry AD, Malloy CR, Finck BN.

J Biol Chem. 2006 Jul 14;281(28):19000-8. Epub 2006 May 2.PMID: 16670093 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice.

De Souza CT, Araújo EP, Prada PO, Saad MJ, Boschero AC, Velloso LA.

Diabetologia. 2005 Sep;48(9):1860-71. Epub 2005 Jul 16.PMID: 16025253 [PubMed - indexed for MEDLINE]Related articles

Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.

Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E945-54. Epub 2009 Feb 10.PMID: 19208857 [PubMed - indexed for MEDLINE]Related articles

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC Jr, Kelly DP.

Cell Metab. 2006 Sep;4(3):199-210.PMID: 16950137 [PubMed - indexed for MEDLINE]Related articles

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.

Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8. Epub 2009 Jun 16.PMID: 19541642 [PubMed - indexed for MEDLINE]Related articles

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. Epub 2008 May 16.PMID: 18487436 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. Epub 2008 Dec 9.PMID: 19066218 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.

Lelliott CJ, Ljungberg A, Ahnmark A, William-Olsson L, Ekroos K, Elmgren A, Arnerup G, Shoulders CC, Oscarsson J, Lindén D.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2707-13. Epub 2007 Oct 11.PMID: 17932310 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.PMID: 17416903 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.

Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T, Lin JD.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E543-8. Epub 2009 Jan 21.PMID: 19158324 [PubMed - indexed for MEDLINE]Related articles

The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism.

Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F.

Endocrinology. 2004 Sep;145(9):4268-77. Epub 2004 Jun 3.PMID: 15178647 [PubMed - indexed for MEDLINE]Related articlesFree article

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 [PubMed - indexed for MEDLINE]Related articlesFree article

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP.

PLoS Biol. 2005 Apr;3(4):e101. Epub 2005 Mar 15.PMID: 15760270 [PubMed - indexed for MEDLINE]Related articlesFree article

PGC-1beta in the regulation of hepatic glucose and energy metabolism.

Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM.

J Biol Chem. 2003 Aug 15;278(33):30843-8. Epub 2003 Jun 13.PMID: 12807885 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha.

Ding X, Lichti K, Kim I, Gonzalez FJ, Staudinger JL.

J Biol Chem. 2006 Sep 8;281(36):26540-51. Epub 2006 Jul 5.PMID: 16825189 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.

Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4012-7. Epub 2003 Mar 21.PMID: 12651943 [PubMed - indexed for MEDLINE]Related articlesFree article

FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver.

Huang X, Yang C, Luo Y, Jin C, Wang F, McKeehan WL.

Diabetes. 2007 Oct;56(10):2501-10. Epub 2007 Jul 30.PMID: 17664243 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.

Croce MA, Eagon JC, LaRiviere LL, Korenblat KM, Klein S, Finck BN.

Diabetes. 2007 Sep;56(9):2395-9. Epub 2007 Jun 11.PMID: 17563064 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation.

Hondares E, Mora O, Yubero P, Rodriguez de la Concepción M, Iglesias R, Giralt M, Villarroya F.

Endocrinology. 2006 Jun;147(6):2829-38. Epub 2006 Mar 2.PMID: 16513826 [PubMed - indexed for MEDLINE]Related articlesFree article