PubMed

Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid morphology.

Abdurahman S, Végvári A, Levi M, Höglund S, Högberg M, Tong W, Romero I, Balzarini J, Vahlne A.

Retrovirology. 2009 Apr 8;6:34.PMID: 19356241 [PubMed - indexed for MEDLINE]Related articlesFree article

Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity.

Abdurahman S, Végvári A, Youssefi M, Levi M, Höglund S, Andersson E, Horal P, Svennerholm B, Balzarini J, Vahlne A.

Antimicrob Agents Chemother. 2008 Oct;52(10):3737-44. Epub 2008 Jul 21.PMID: 18644965 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide.

Andersson E, Horal P, Jejcic A, Höglund S, Balzarini J, Vahlne A, Svennerholm B.

Antimicrob Agents Chemother. 2005 Jan;49(1):40-4.PMID: 15616273 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiviral inhibition of the HIV-1 capsid protein.

Tang C, Loeliger E, Kinde I, Kyere S, Mayo K, Barklis E, Sun Y, Huang M, Summers MF.

J Mol Biol. 2003 Apr 11;327(5):1013-20.PMID: 12662926 [PubMed - indexed for MEDLINE]Related articles

New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation.

Blair WS, Cao J, Fok-Seang J, Griffin P, Isaacson J, Jackson RL, Murray E, Patick AK, Peng Q, Perros M, Pickford C, Wu H, Butler SL.

Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7. Epub 2009 Oct 5.PMID: 19805571 [PubMed - indexed for MEDLINE]Related articles

Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.

Li J, Tan Z, Tang S, Hewlett I, Pang R, He M, He S, Tian B, Chen K, Yang M.

Bioorg Med Chem. 2009 Apr 15;17(8):3177-88. Epub 2009 Mar 3.PMID: 19328002 [PubMed - indexed for MEDLINE]Related articles

A cell-penetrating helical peptide as a potential HIV-1 inhibitor.

Zhang H, Zhao Q, Bhattacharya S, Waheed AA, Tong X, Hong A, Heck S, Curreli F, Goger M, Cowburn D, Freed EO, Debnath AK.

J Mol Biol. 2008 May 2;378(3):565-80. Epub 2008 Mar 6.PMID: 18374356 [PubMed - indexed for MEDLINE]Related articlesFree article

Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).

Balzarini J, Andersson E, Schols D, Proost P, Van Damme J, Svennerholm B, Horal P, Vahlne A.

Int J Biochem Cell Biol. 2004 Sep;36(9):1848-59.PMID: 15183349 [PubMed - indexed for MEDLINE]Related articles

2,2'-Dithiobisbenzamides derived from alpha-, beta- and gamma-amino acids possessing anti-HIV activities: synthesis and structure-activity relationship.

Prasad JV, Loo JA, Boyer FE, Stier MA, Gogliotti RD, Turner WJ, Harvey PJ, Kramer MR, Mack DP, Scholten JD, Gracheck SJ, Domagala JM.

Bioorg Med Chem. 1998 Oct;6(10):1707-30.PMID: 9839002 [PubMed - indexed for MEDLINE]Related articles

Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein.

Tian B, He M, Tang S, Hewlett I, Tan Z, Li J, Jin Y, Yang M.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2162-7. Epub 2009 Mar 4.PMID: 19297155 [PubMed - indexed for MEDLINE]Related articles

Tripeptide interference with human immunodeficiency virus type 1 morphogenesis.

Höglund S, Su J, Reneby SS, Végvári A, Hjertén S, Sintorn IM, Foster H, Wu YP, Nyström I, Vahlne A.

Antimicrob Agents Chemother. 2002 Nov;46(11):3597-605.PMID: 12384371 [PubMed - indexed for MEDLINE]Related articlesFree article

Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein.

Bartonova V, Igonet S, Sticht J, Glass B, Habermann A, Vaney MC, Sehr P, Lewis J, Rey FA, Kraüsslich HG.

J Biol Chem. 2008 Nov 14;283(46):32024-33. Epub 2008 Sep 4.PMID: 18772135 [PubMed - indexed for MEDLINE]Related articlesFree article

Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.

Goel A, Mazur SJ, Fattah RJ, Hartman TL, Turpin JA, Huang M, Rice WG, Appella E, Inman JK.

Bioorg Med Chem Lett. 2002 Mar 11;12(5):767-70.PMID: 11858998 [PubMed - indexed for MEDLINE]Related articles

The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly.

Neira JL.

FEBS J. 2009 Nov;276(21):6110-7. Review.PMID: 19825045 [PubMed - indexed for MEDLINE]Related articles

GPG-NH2 acts via the metabolite alphaHGA to target HIV-1 Env to the ER-associated protein degradation pathway.

Jejcic A, Hoglund S, Vahlne A.

Retrovirology. 2010 Mar 15;7(1):20. [Epub ahead of print]PMID: 20230608 [PubMed - as supplied by publisher]Related articles

HIV-1 capsid protein and cyclophilin a as new targets for anti-AIDS therapeutic agents.

Li J, Tang S, Hewlett I, Yang M.

Infect Disord Drug Targets. 2007 Sep;7(3):238-44. Review.PMID: 17897064 [PubMed - indexed for MEDLINE]Related articles

Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity.

Abdurahman S, Höglund S, Höglund A, Vahlne A.

Retrovirology. 2007 Mar 19;4:19.PMID: 17371591 [PubMed - indexed for MEDLINE]Related articlesFree article

An in vitro fluorescence screen to identify antivirals that disrupt hepatitis B virus capsid assembly.

Stray SJ, Johnson JM, Kopek BG, Zlotnick A.

Nat Biotechnol. 2006 Mar;24(3):358-62. Epub 2006 Feb 12.PMID: 16474383 [PubMed - indexed for MEDLINE]Related articles

Characterization of the invariable residue 51 mutations of human immunodeficiency virus type 1 capsid protein on in vitro CA assembly and infectivity.

Abdurahman S, Youssefi M, Höglund S, Vahlne A.

Retrovirology. 2007 Sep 28;4:69.PMID: 17903253 [PubMed - indexed for MEDLINE]Related articlesFree article

Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

Stoddart CA, Joshi P, Sloan B, Bare JC, Smith PC, Allaway GP, Wild CT, Martin DE.

PLoS One. 2007 Nov 28;2(11):e1251.PMID: 18043758 [PubMed - indexed for MEDLINE]Related articlesFree article