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Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function.

Gloyn AL, Braun M, Rorsman P.

Diabetes. 2009 Apr;58(4):800-2. No abstract available. PMID: 19336690 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells.

da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA.

Diabetes. 2009 Apr;58(4):894-905. Epub 2009 Jan 23.PMID: 19168596 [PubMed - indexed for MEDLINE]Related articlesFree article

Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.

Nordman S, Ostenson CG, Efendic S, Gu HF.

Exp Clin Endocrinol Diabetes. 2009 Apr;117(4):186-90. Epub 2008 Dec 3.PMID: 19053027 [PubMed - indexed for MEDLINE]Related articles

The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus.

Jin T, Liu L.

Mol Endocrinol. 2008 Nov;22(11):2383-92. Epub 2008 Jul 3. Review.PMID: 18599616 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ.

Diabetes. 2007 Jul;56(7):1943-7. Epub 2007 Apr 6.PMID: 17416797 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.

Chandak GR, Janipalli CS, Bhaskar S, Kulkarni SR, Mohankrishna P, Hattersley AT, Frayling TM, Yajnik CS.

Diabetologia. 2007 Jan;50(1):63-7. Epub 2006 Nov 9.PMID: 17093941 [PubMed - indexed for MEDLINE]Related articles

TCF7L2 and type 2 diabetes--we WNT to know.

Smith U.

Diabetologia. 2007 Jan;50(1):5-7. Epub 2006 Nov 11. No abstract available. PMID: 17102948 [PubMed - indexed for MEDLINE]Related articles

Prime suspect: the TCF7L2 gene and type 2 diabetes risk.

Hattersley AT.

J Clin Invest. 2007 Aug;117(8):2077-9.PMID: 17671643 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.

Saadi H, Nagelkerke N, Carruthers SG, Benedict S, Abdulkhalek S, Reed R, Lukic M, Nicholls MG.

Diabetes Res Clin Pract. 2008 Jun;80(3):392-8. Epub 2008 Feb 20.PMID: 18282631 [PubMed - indexed for MEDLINE]Related articles

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells.

Loder MK, da Silva Xavier G, McDonald A, Rutter GA.

Biochem Soc Trans. 2008 Jun;36(Pt 3):357-9.PMID: 18481957 [PubMed - indexed for MEDLINE]Related articles

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.

Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K.

Nat Genet. 2006 Mar;38(3):320-3. Epub 2006 Jan 15.PMID: 16415884 [PubMed - indexed for MEDLINE]Related articles

Translating TCF7L2: from gene to function.

Pearson ER.

Diabetologia. 2009 Jul;52(7):1227-30. Epub 2009 Apr 22. No abstract available. PMID: 19387612 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR.

Diabetes. 2006 Sep;55(9):2654-9.PMID: 16936218 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.

Cauchi S, Meyre D, Dina C, Choquet H, Samson C, Gallina S, Balkau B, Charpentier G, Pattou F, Stetsyuk V, Scharfmann R, Staels B, Frühbeck G, Froguel P.

Diabetes. 2006 Oct;55(10):2903-8.PMID: 17003360 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L.

J Clin Invest. 2007 Aug;117(8):2155-63.PMID: 17671651 [PubMed - indexed for MEDLINE]Related articlesFree article

The importance of TCF7L2.

Weedon MN.

Diabet Med. 2007 Oct;24(10):1062-6. Review.PMID: 17888129 [PubMed - indexed for MEDLINE]Related articles

No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects.

Cauchi S, Vaxillaire M, Choquet H, Durand E, Duval A, Polak M, Froguel P.

Diabetologia. 2007 Jan;50(1):214-6. Epub 2006 Nov 9. No abstract available. PMID: 17093940 [PubMed - indexed for MEDLINE]Related articles

Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.

Dahlgren A, Zethelius B, Jensevik K, Syvänen AC, Berne C; ULSAM Cohort.

Diabetologia. 2007 Sep;50(9):1852-7. Epub 2007 Jul 6.PMID: 17618413 [PubMed - indexed for MEDLINE]Related articles

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.

Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T.

Diabetologia. 2007 Apr;50(4):747-51. Epub 2007 Jan 24.PMID: 17245589 [PubMed - indexed for MEDLINE]Related articles

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.

van Vliet-Ostaptchouk JV, Shiri-Sverdlov R, Zhernakova A, Strengman E, van Haeften TW, Hofker MH, Wijmenga C.

Diabetologia. 2007 Jan;50(1):59-62. Epub 2006 Oct 10.PMID: 17031610 [PubMed - indexed for MEDLINE]Related articles