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    Results: 1 to 20 of 135

    1.

    PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

    Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL.

    Diabetes. 2009 Jun;58(6):1283-91. Epub 2009 Mar 31.PMID: 19336676 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.

    Liu D, Darville M, Eizirik DL.

    Endocrinology. 2001 Jun;142(6):2593-9.PMID: 11356709 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

    Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR.

    Diabetes. 2008 Nov;57(11):3034-44. Epub 2008 Jun 30.PMID: 18591394 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

    Liu D, Cardozo AK, Darville MI, Eizirik DL.

    Endocrinology. 2002 Apr;143(4):1225-34.PMID: 11897677 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappaB activation.

    Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH.

    Exp Mol Med. 2007 Apr 30;39(2):149-59.PMID: 17464176 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.

    Karlsen AE, Rønn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N.

    Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12191-6. Epub 2001 Oct 2.PMID: 11593036 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Radix asari extract protects pancreatic beta cells against cytokine-induced toxicity: implication of the NF-kappaB-iNOS signaling cascade.

    Song MY, Kim KA, Lee SY, Kim EK, Lv N, Lee JH, Park JW, Ryu DG, Kwon KB, Park BH.

    Int J Mol Med. 2007 Nov;20(5):769-75.PMID: 17912472 [PubMed - indexed for MEDLINE]Related articles

    8.

    The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.

    Pavlovic D, Chen MC, Gysemans CA, Mathieu C, Eizirik DL.

    Eur Cytokine Netw. 1999 Sep;10(3):403-12.PMID: 10477397 [PubMed - indexed for MEDLINE]Related articles

    9.

    Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

    Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.

    Diabetologia. 2008 Jul;51(7):1213-25. Epub 2008 May 8.PMID: 18463842 [PubMed - indexed for MEDLINE]Related articles

    10.

    IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells.

    Jacobsen ML, Rønn SG, Bruun C, Larsen CM, Eizirik DL, Mandrup-Poulsen T, Billestrup N.

    Diabetologia. 2009 Feb;52(2):281-8. Epub 2008 Nov 11.PMID: 19002429 [PubMed - indexed for MEDLINE]Related articles

    11.

    Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.

    Rasschaert J, Ladrière L, Urbain M, Dogusan Z, Katabua B, Sato S, Akira S, Gysemans C, Mathieu C, Eizirik DL.

    J Biol Chem. 2005 Oct 7;280(40):33984-91. Epub 2005 Jul 15.PMID: 16027122 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation.

    Kim EK, Kwon KB, Song MY, Han MJ, Lee JH, Lee YR, Lee JH, Ryu DG, Park BH, Park JW.

    Pancreas. 2007 Nov;35(4):e1-9.PMID: 18090225 [PubMed - indexed for MEDLINE]Related articles

    13.

    Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.

    Pirot P, Eizirik DL, Cardozo AK.

    Diabetologia. 2006 Jun;49(6):1229-36. Epub 2006 Apr 8.PMID: 16604358 [PubMed - indexed for MEDLINE]Related articles

    14.

    Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.

    Dupraz P, Cottet S, Hamburger F, Dolci W, Felley-Bosco E, Thorens B.

    J Biol Chem. 2000 Dec 1;275(48):37672-8.PMID: 10967106 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

    Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL.

    Diabetologia. 2001 Mar;44(3):325-32.PMID: 11317664 [PubMed - indexed for MEDLINE]Related articles

    16.

    Cytokine-induced osteoprotegerin expression protects pancreatic beta cells through p38 mitogen-activated protein kinase signalling against cell death.

    Schrader J, Rennekamp W, Niebergall U, Schoppet M, Jahr H, Brendel MD, Hörsch D, Hofbauer LC.

    Diabetologia. 2007 Jun;50(6):1243-7. Epub 2007 Apr 19.PMID: 17443309 [PubMed - indexed for MEDLINE]Related articles

    17.

    Effect of iNOS and NF-kappaB gene silencing on beta-cell survival and function.

    De Paula D, Bentley MV, Mahato RI.

    J Drug Target. 2007 Jun;15(5):358-69.PMID: 17541845 [PubMed - indexed for MEDLINE]Related articles

    18.

    Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.

    Hong TP, Andersen NA, Nielsen K, Karlsen AE, Fantuzzi G, Eizirik DL, Dinarello CA, Mandrup-Poulsen T.

    Eur Cytokine Netw. 2000 Jun;11(2):193-205.PMID: 10903798 [PubMed - indexed for MEDLINE]Related articles

    19.

    Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway.

    Kim EK, Kwon KB, Koo BS, Han MJ, Song MY, Song EK, Han MK, Park JW, Ryu DG, Park BH.

    Int J Biochem Cell Biol. 2007;39(6):1260-75. Epub 2007 Apr 19.PMID: 17521952 [PubMed - indexed for MEDLINE]Related articles

    20.

    IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death.

    Suk K, Kim S, Kim YH, Kim KA, Chang I, Yagita H, Shong M, Lee MS.

    J Immunol. 2001 Apr 1;166(7):4481-9.PMID: 11254704 [PubMed - indexed for MEDLINE]Related articlesFree article

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