PubMed

Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.

Wang Y, Feng W, Xue W, Tan Y, Hein DW, Li XK, Cai L.

Diabetes. 2009 Jun;58(6):1391-402. Epub 2009 Mar 26.PMID: 19324938 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.

Zhou G, Li X, Hein DW, Xiang X, Marshall JP, Prabhu SD, Cai L.

J Am Coll Cardiol. 2008 Aug 19;52(8):655-66.PMID: 18702970 [PubMed - indexed for MEDLINE]Related articles

Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy.

Cai L, Wang Y, Zhou G, Chen T, Song Y, Li X, Kang YJ.

J Am Coll Cardiol. 2006 Oct 17;48(8):1688-97. Epub 2006 Sep 27.PMID: 17045908 [PubMed - indexed for MEDLINE]Related articles

Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury.

Song Y, Wang J, Li Y, Du Y, Arteel GE, Saari JT, Kang YJ, Cai L.

Am J Pathol. 2005 Jul;167(1):17-26.PMID: 15972948 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy.

Cai L, Wang J, Li Y, Sun X, Wang L, Zhou Z, Kang YJ.

Diabetes. 2005 Jun;54(6):1829-37.PMID: 15919806 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation.

Wang J, Song Y, Elsherif L, Song Z, Zhou G, Prabhu SD, Saari JT, Cai L.

Circulation. 2006 Jan 31;113(4):544-54. Epub 2006 Jan 23.PMID: 16432057 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glycogen synthase kinase 3beta during heart failure is protective.

Hirotani S, Zhai P, Tomita H, Galeotti J, Marquez JP, Gao S, Hong C, Yatani A, Avila J, Sadoshima J.

Circ Res. 2007 Nov 26;101(11):1164-74. Epub 2007 Sep 27.PMID: 17901358 [PubMed - indexed for MEDLINE]Related articlesFree article

Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus.

Thandavarayan RA, Watanabe K, Ma M, Gurusamy N, Veeraveedu PT, Konishi T, Zhang S, Muslin AJ, Kodama M, Aizawa Y.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H911-9. Epub 2009 Jul 17.PMID: 19617408 [PubMed - indexed for MEDLINE]Related articles

Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases.

Zhai P, Gao S, Holle E, Yu X, Yatani A, Wagner T, Sadoshima J.

J Biol Chem. 2007 Nov 9;282(45):33181-91. Epub 2007 Sep 12.PMID: 17855351 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glycogen synthase kinase-3beta improves tolerance to ischemia in hypertrophied hearts.

Barillas R, Friehs I, Cao-Danh H, Martinez JF, del Nido PJ.

Ann Thorac Surg. 2007 Jul;84(1):126-33.PMID: 17588398 [PubMed - indexed for MEDLINE]Related articles

Diacylglycerol kinase zeta inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus.

Bilim O, Takeishi Y, Kitahara T, Arimoto T, Niizeki T, Sasaki T, Goto K, Kubota I.

Cardiovasc Diabetol. 2008 Feb 4;7:2.PMID: 18241357 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.

Luckey SW, Walker LA, Smyth T, Mansoori J, Messmer-Kratzsch A, Rosenzweig A, Olson EN, Leinwand LA.

J Mol Cell Cardiol. 2009 May;46(5):739-47. Epub 2009 Feb 21.PMID: 19233194 [PubMed - indexed for MEDLINE]Related articles

Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection.

Xu J, Wang G, Wang Y, Liu Q, Xu W, Tan Y, Cai L.

J Cell Mol Med. 2009 Aug;13(8A):1499-512. Epub 2009 Jul 6.PMID: 19583814 [PubMed - in process]Related articles

Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta.

Collino M, Aragno M, Castiglia S, Tomasinelli C, Thiemermann C, Boccuzzi G, Fantozzi R.

Diabetes. 2009 Jan;58(1):235-42. Epub 2008 Oct 7.PMID: 18840784 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation.

Li HJ, Yin H, Yao YY, Shen B, Bader M, Chao L, Chao J.

Cardiovasc Res. 2007 Jan 1;73(1):130-42. Epub 2006 Oct 27.PMID: 17137568 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA.

PLoS Biol. 2008 Feb;6(2):e37.PMID: 18288891 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.

Pearce NJ, Arch JR, Clapham JC, Coghlan MP, Corcoran SL, Lister CA, Llano A, Moore GB, Murphy GJ, Smith SA, Taylor CM, Yates JW, Morrison AD, Harper AJ, Roxbee-Cox L, Abuin A, Wargent E, Holder JC.

Metabolism. 2004 Oct;53(10):1322-30.PMID: 15375789 [PubMed - indexed for MEDLINE]Related articles

Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.

Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB.

J Biol Chem. 2004 Sep 17;279(38):39541-54. Epub 2004 Jul 13.PMID: 15252041 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse.

Cuzzocrea S, Mazzon E, Di Paola R, Muià C, Crisafulli C, Dugo L, Collin M, Britti D, Caputi AP, Thiemermann C.

Clin Immunol. 2006 Jul;120(1):57-67. Epub 2006 May 2.PMID: 16631408 [PubMed - indexed for MEDLINE]Related articles

Overexpression of metallothionein reduces diabetic cardiomyopathy.

Liang Q, Carlson EC, Donthi RV, Kralik PM, Shen X, Epstein PN.

Diabetes. 2002 Jan;51(1):174-81.PMID: 11756338 [PubMed - indexed for MEDLINE]Related articlesFree article