PubMed

Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours.

Buhles A, Collins SA, van Pijkeren JP, Rajendran S, Miles M, O'Sullivan GC, O'Hanlon DM, Tangney M.

Genet Vaccines Ther. 2009 Mar 9;7:5.PMID: 19272140 [PubMed - in process]Related articlesFree article

Adenoviral-mediated gene transduction of the hepatocyte growth factor (HGF) antagonist, NK4, suppresses peritoneal metastases of gastric cancer in nude mice.

Ueda K, Iwahashi M, Matsuura I, Nakamori M, Nakamura M, Ojima T, Naka T, Ishida K, Matsumoto K, Nakamura T, Yamaue H.

Eur J Cancer. 2004 Sep;40(14):2135-42.PMID: 15341989 [PubMed - indexed for MEDLINE]Related articles

Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist.

Martin TA, Parr C, Davies G, Watkins G, Lane J, Matsumoto K, Nakamura T, Mansel RE, Jiang WG.

Carcinogenesis. 2003 Aug;24(8):1317-23. Epub 2003 May 9.PMID: 12807719 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice.

Wen J, Matsumoto K, Taniura N, Tomioka D, Nakamura T.

Cancer Gene Ther. 2004 Jun;11(6):419-30.PMID: 15017381 [PubMed - indexed for MEDLINE]Related articles

NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics.

Matsumoto K, Nakamura T.

Cancer Sci. 2003 Apr;94(4):321-7. Review.PMID: 12824898 [PubMed - indexed for MEDLINE]Related articles

Targeting angiogenesis and HGF function using an adenoviral vector expressing the HGF antagonist NK4 for cancer therapy.

Maemondo M, Narumi K, Saijo Y, Usui K, Tahara M, Tazawa R, Hagiwara K, Matsumoto K, Nakamura T, Nukiwa T.

Mol Ther. 2002 Feb;5(2):177-85.PMID: 11829525 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-cancer approach with NK4: Bivalent action and mechanisms.

Nakamura T, Sakai K, Nakamura T, Matsumoto K.

Anticancer Agents Med Chem. 2010 Jan 1;10(1):36-46.PMID: 20015005 [PubMed - in process]Related articles

NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells.

Kubota T, Taiyoh H, Matsumura A, Murayama Y, Ichikawa D, Okamoto K, Fujiwara H, Ikoma H, Nakanishi M, Kikuchi S, Sakakura C, Ochiai T, Kokuba Y, Taniguchi H, Sonoyama T, Matsumoto K, Nakamura T, Otsuji E.

Clin Exp Metastasis. 2009;26(5):447-56. Epub 2009 Feb 21.PMID: 19234748 [PubMed - indexed for MEDLINE]Related articles

Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models.

Kishi Y, Kuba K, Nakamura T, Wen J, Suzuki Y, Mizuno S, Nukiwa T, Matsumoto K, Nakamura T.

Cancer Sci. 2009 Jul;100(7):1351-8. Epub 2009 May 12.PMID: 19438869 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4.

Matsumoto K, Nakamura T, Sakai K, Nakamura T.

Proteomics. 2008 Aug;8(16):3360-70. Review.PMID: 18646008 [PubMed - indexed for MEDLINE]Related articles

NK4 gene therapy targeting HGF-Met and angiogenesis.

Matsumoto K, Nakamura T.

Front Biosci. 2008 Jan 1;13:1943-51. Review.PMID: 17981681 [PubMed - indexed for MEDLINE]Related articles

Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy.

Heideman DA, Overmeer RM, van Beusechem VW, Lamers WH, Hakvoort TB, Snijders PJ, Craanen ME, Offerhaus GJ, Meijer CJ, Gerritsen WR.

Cancer Gene Ther. 2005 Dec;12(12):954-62.PMID: 15905856 [PubMed - indexed for MEDLINE]Related articles

Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice.

Wen J, Matsumoto K, Taniura N, Tomioka D, Nakamura T.

Biochem Biophys Res Commun. 2007 Jun 22;358(1):117-23. Epub 2007 Apr 23.PMID: 17467663 [PubMed - indexed for MEDLINE]Related articles

Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association.

Sakai K, Nakamura T, Matsumoto K, Nakamura T.

J Biol Chem. 2009 Aug 14;284(33):22491-9. Epub 2009 Jun 24.PMID: 19553700 [PubMed - indexed for MEDLINE]Related articles

Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice.

Son G, Hirano T, Seki E, Iimuro Y, Nukiwa T, Matsumoto K, Nakamura T, Fujimoto J.

J Hepatol. 2006 Nov;45(5):688-95. Epub 2006 May 30.PMID: 16839638 [PubMed - indexed for MEDLINE]Related articles

Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma.

Suzuki Y, Sakai K, Ueki J, Xu Q, Nakamura T, Shimada H, Nakamura T, Matsumoto K.

Int J Cancer. 2010 Jan 26. [Epub ahead of print]PMID: 20104519 [PubMed - as supplied by publisher]Related articles

NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor.

Du W, Hattori Y, Yamada T, Matsumoto K, Nakamura T, Sagawa M, Otsuki T, Niikura T, Nukiwa T, Ikeda Y.

Blood. 2007 Apr 1;109(7):3042-9.PMID: 17179234 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms and significance of bifunctional NK4 in cancer treatment.

Matsumoto K, Nakamura T.

Biochem Biophys Res Commun. 2005 Jul 29;333(2):316-27. Review.PMID: 15950947 [PubMed - indexed for MEDLINE]Related articles

Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin.

Kushibiki T, Matsumoto K, Nakamura T, Tabata Y.

Gene Ther. 2004 Aug;11(15):1205-14.PMID: 15103321 [PubMed - indexed for MEDLINE]Related articles

Gene transfer of NK4, an angiogenesis inhibitor, induces CT26 tumor regression via tumor-specific T lymphocyte activation.

Kubota T, Taiyoh H, Matsumura A, Murayama Y, Ichikawa D, Okamoto K, Fujiwara H, Ikoma H, Nakanishi M, Kikuchi S, Ochiai T, Sakakura C, Kokuba Y, Sonoyama T, Suzuki Y, Matsumoto K, Nakamura T, Otsuji E.

Int J Cancer. 2009 Dec 15;125(12):2879-86.PMID: 19588506 [PubMed - indexed for MEDLINE]Related articles