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    Results: 1 to 20 of 118

    1.

    Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia.

    Hamada S, Hara K, Hamada T, Yasuda H, Moriyama H, Nakayama R, Nagata M, Yokono K.

    Diabetes. 2009 Jun;58(6):1321-32. Epub 2009 Mar 3.PMID: 19258434 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.

    Mwangi S, Anitha M, Mallikarjun C, Ding X, Hara M, Parsadanian A, Larsen CP, Thule P, Sitaraman SV, Anania F, Srinivasan S.

    Gastroenterology. 2008 Mar;134(3):727-37. Epub 2008 Feb 1.PMID: 18241861 [PubMed - indexed for MEDLINE]Related articles

    3.

    Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.

    Sato T, Umetsu A, Tamanoi F.

    Methods Enzymol. 2008;438:307-20.PMID: 18413257 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Regulation of pancreatic beta-cell mass and proliferation by SOCS-3.

    Lindberg K, Rønn SG, Tornehave D, Richter H, Hansen JA, Rømer J, Jackerott M, Billestrup N.

    J Mol Endocrinol. 2005 Oct;35(2):231-43.PMID: 16216905 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation.

    Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS, Hunzicker-Dunn M.

    J Biol Chem. 2004 May 7;279(19):19431-40. Epub 2004 Feb 24.PMID: 14982927 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes.

    Wang Y, Huang BP, Luciani DS, Wang X, Johnson JD, Proud CG.

    J Mol Cell Cardiol. 2008 Dec;45(6):812-20. Epub 2008 Aug 3.PMID: 18722381 [PubMed - indexed for MEDLINE]Related articles

    7.

    Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.

    Wang X, Fonseca BD, Tang H, Liu R, Elia A, Clemens MJ, Bommer UA, Proud CG.

    J Biol Chem. 2008 Nov 7;283(45):30482-92. Epub 2008 Aug 1.PMID: 18676370 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.

    Lee MN, Ha SH, Kim J, Koh A, Lee CS, Kim JH, Jeon H, Kim DH, Suh PG, Ryu SH.

    Mol Cell Biol. 2009 Jul;29(14):3991-4001. Epub 2009 May 18.PMID: 19451232 [PubMed - indexed for MEDLINE]Related articles

    9.

    Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain.

    Yu J, Henske EP.

    Cancer Res. 2006 Oct 1;66(19):9461-6.PMID: 17018601 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

    Masson E, Koren S, Razik F, Goldberg H, Kwan EP, Sheu L, Gaisano HY, Fantus IG.

    Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1251-61. Epub 2009 Feb 17.PMID: 19223654 [PubMed - indexed for MEDLINE]Related articles

    11.

    Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.

    Sato T, Nakashima A, Guo L, Tamanoi F.

    J Biol Chem. 2009 May 8;284(19):12783-91. Epub 2009 Mar 19.PMID: 19299511 [PubMed - indexed for MEDLINE]Related articles

    12.

    Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.

    Gelling RW, Vuguin PM, Du XQ, Cui L, Rømer J, Pederson RA, Leiser M, Sørensen H, Holst JJ, Fledelius C, Johansen PB, Fleischer N, McIntosh CH, Nishimura E, Charron MJ.

    Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E695-707. Epub 2009 Jul 14.PMID: 19602585 [PubMed - indexed for MEDLINE]Related articles

    13.

    Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

    Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A.

    Diabetes. 2007 Nov;56(11):2732-43. Epub 2007 Aug 8.PMID: 17686945 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

    Rachdi L, Balcazar N, Osorio-Duque F, Elghazi L, Weiss A, Gould A, Chang-Chen KJ, Gambello MJ, Bernal-Mizrachi E.

    Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9250-5. Epub 2008 Jun 27.PMID: 18587048 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

    Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.

    PLoS One. 2009;4(3):e4954. Epub 2009 Mar 23.PMID: 19305497 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice.

    Shigeyama Y, Kobayashi T, Kido Y, Hashimoto N, Asahara S, Matsuda T, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Uchida T, Inoue M, Hino O, Kasuga M, Noda T.

    Mol Cell Biol. 2008 May;28(9):2971-9. Epub 2008 Mar 3.PMID: 18316403 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt.

    Yano T, Liu Z, Donovan J, Thomas MK, Habener JF.

    Diabetes. 2007 Dec;56(12):2946-57. Epub 2007 Sep 18.PMID: 17878289 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Rheb activation of mTOR and S6K1 signaling.

    Hanrahan J, Blenis J.

    Methods Enzymol. 2006;407:542-55.PMID: 16757352 [PubMed - indexed for MEDLINE]Related articles

    19.

    Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition.

    Dunlop EA, Dodd KM, Seymour LA, Tee AR.

    Cell Signal. 2009 Jul;21(7):1073-84. Epub 2009 Mar 9.PMID: 19272448 [PubMed - indexed for MEDLINE]Related articles

    20.

    mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability.

    Balcazar N, Sathyamurthy A, Elghazi L, Gould A, Weiss A, Shiojima I, Walsh K, Bernal-Mizrachi E.

    J Biol Chem. 2009 Mar 20;284(12):7832-42. Epub 2009 Jan 14.PMID: 19144649 [PubMed - indexed for MEDLINE]Related articles

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