PubMed

Type 2 diabetes risk alleles are associated with reduced size at birth.

Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, Timpson NJ, Weedon MN, Zeggini E, Lindgren CM, Lango H, Perry JR, Pouta A, Ruokonen A, Hyppönen E, Power C, Elliott P, Strachan DP, Järvelin MR, Smith GD, McCarthy MI, Frayling TM, Hattersley AT.

Diabetes. 2009 Jun;58(6):1428-33. Epub 2009 Feb 19.PMID: 19228808 [PubMed - indexed for MEDLINE]Related articlesFree article

HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.

Winkler C, Illig T, Koczwara K, Bonifacio E, Ziegler AG.

J Clin Endocrinol Metab. 2009 Oct;94(10):4113-5. Epub 2009 Jul 21.PMID: 19622614 [PubMed - indexed for MEDLINE]Related articles

Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

Wu Y, Li H, Loos RJ, Yu Z, Ye X, Chen L, Pan A, Hu FB, Lin X.

Diabetes. 2008 Oct;57(10):2834-42. Epub 2008 Jul 15.PMID: 18633108 [PubMed - indexed for MEDLINE]Related articlesFree article

Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.

Zhao J, Li M, Bradfield JP, Wang K, Zhang H, Sleiman P, Kim CE, Annaiah K, Glaberson W, Glessner JT, Otieno FG, Thomas KA, Garris M, Hou C, Frackelton EC, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF.

Diabetes. 2009 Oct;58(10):2414-8. Epub 2009 Jul 10.PMID: 19592620 [PubMed - indexed for MEDLINE]Related articles

Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.

Rong R, Hanson RL, Ortiz D, Wiedrich C, Kobes S, Knowler WC, Bogardus C, Baier LJ.

Diabetes. 2009 Feb;58(2):478-88. Epub 2008 Nov 13.PMID: 19008344 [PubMed - indexed for MEDLINE]Related articlesFree article

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

Ng MC, Park KS, Oh B, Tam CH, Cho YM, Shin HD, Lam VK, Ma RC, So WY, Cho YS, Kim HL, Lee HK, Chan JC, Cho NH.

Diabetes. 2008 Aug;57(8):2226-33. Epub 2008 May 9.PMID: 18469204 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.

Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium.

Diabetes. 2007 Dec;56(12):3101-4. Epub 2007 Sep 5.PMID: 17804762 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, Albrechtsen A, Clausen JO, Rasmussen SS, Jørgensen T, Sandbaek A, Lauritzen T, Schmitz O, Hansen T, Pedersen O.

Diabetes. 2007 Dec;56(12):3105-11. Epub 2007 Sep 7.PMID: 17827400 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.

Lee YH, Kang ES, Kim SH, Han SJ, Kim CH, Kim HJ, Ahn CW, Cha BS, Nam M, Nam CM, Lee HC.

J Hum Genet. 2008;53(11-12):991-8. Epub 2008 Nov 11.PMID: 18991055 [PubMed - indexed for MEDLINE]Related articles

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.

Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Nakamura Y, Maeda S.

Diabetes. 2008 Mar;57(3):791-5. Epub 2007 Dec 27.PMID: 18162508 [PubMed - indexed for MEDLINE]Related articlesFree article

Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.

Moore AF, Jablonski KA, McAteer JB, Saxena R, Pollin TI, Franks PW, Hanson RL, Shuldiner AR, Knowler WC, Altshuler D, Florez JC; Diabetes Prevention Program Research Group.

Diabetes. 2008 Sep;57(9):2503-10. Epub 2008 Jun 10.PMID: 18544707 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies.

Herder C, Rathmann W, Strassburger K, Finner H, Grallert H, Huth C, Meisinger C, Gieger C, Martin S, Giani G, Scherbaum WA, Wichmann HE, Illig T.

Horm Metab Res. 2008 Oct;40(10):722-6. Epub 2008 Jul 2.PMID: 18597214 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.

Freathy RM, Weedon MN, Bennett A, Hypponen E, Relton CL, Knight B, Shields B, Parnell KS, Groves CJ, Ring SM, Pembrey ME, Ben-Shlomo Y, Strachan DP, Power C, Jarvelin MR, McCarthy MI, Davey Smith G, Hattersley AT, Frayling TM.

Am J Hum Genet. 2007 Jun;80(6):1150-61. Epub 2007 Apr 23.PMID: 17503332 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes.

Pulizzi N, Lyssenko V, Jonsson A, Osmond C, Laakso M, Kajantie E, Barker DJ, Groop LC, Eriksson JG.

Diabetologia. 2009 May;52(5):825-9. Epub 2009 Feb 19.PMID: 19225753 [PubMed - indexed for MEDLINE]Related articles

Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.

Horikawa Y, Miyake K, Yasuda K, Enya M, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Kasuga M.

J Clin Endocrinol Metab. 2008 Aug;93(8):3136-41. Epub 2008 May 13.PMID: 18477659 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population.

Furukawa Y, Shimada T, Furuta H, Matsuno S, Kusuyama A, Doi A, Nishi M, Sasaki H, Sanke T, Nanjo K.

J Clin Endocrinol Metab. 2008 Jan;93(1):310-4. Epub 2007 Oct 30.PMID: 17971426 [PubMed - indexed for MEDLINE]Related articlesFree article

Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.

Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Miki T, Kohara K, Makino H.

Diabetes. 2009 Feb;58(2):493-8. Epub 2008 Nov 25.PMID: 19033397 [PubMed - indexed for MEDLINE]Related articlesFree article

Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.

Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, Froguel P, Kadowaki T.

Diabetologia. 2007 Dec;50(12):2461-6. Epub 2007 Oct 10.PMID: 17928989 [PubMed - indexed for MEDLINE]Related articles

Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.

Lewis JP, Palmer ND, Hicks PJ, Sale MM, Langefeld CD, Freedman BI, Divers J, Bowden DW.

Diabetes. 2008 Aug;57(8):2220-5. Epub 2008 Apr 28.PMID: 18443202 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M; RISC Consortium.

Diabetologia. 2008 Nov;51(11):1989-92. Epub 2008 Aug 22.PMID: 18719881 [PubMed - indexed for MEDLINE]Related articles