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    Results: 1 to 20 of 213

    1.

    Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.

    Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S.

    Diabetes. 2009 May;58(5):1105-15. Epub 2009 Feb 17.PMID: 19223597 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Cooperative effects between protein kinase A and p44/p42 mitogen-activated protein kinase to promote cAMP-responsive element binding protein activation after beta cell stimulation by glucose and its alteration due to glucotoxicity.

    Costes S, Longuet C, Broca C, Faruque O, Hani EH, Bataille D, Dalle S.

    Ann N Y Acad Sci. 2004 Dec;1030:230-42.PMID: 15659802 [PubMed - indexed for MEDLINE]Related articles

    3.

    Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line.

    Oetjen E, Lechleiter A, Blume R, Nihalani D, Holzman L, Knepel W.

    Diabetologia. 2006 Feb;49(2):332-42. Epub 2005 Dec 21.PMID: 16369771 [PubMed - indexed for MEDLINE]Related articles

    4.

    Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.

    Casas S, Gomis R, Gribble FM, Altirriba J, Knuutila S, Novials A.

    Diabetes. 2007 Sep;56(9):2284-94. Epub 2007 Jun 11.PMID: 17563070 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival.

    Costes S, Broca C, Bertrand G, Lajoix AD, Bataille D, Bockaert J, Dalle S.

    Diabetes. 2006 Aug;55(8):2220-30.PMID: 16873684 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

    Shaked M, Ketzinel-Gilad M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

    Diabetologia. 2009 Apr;52(4):636-44. Epub 2009 Feb 13.PMID: 19214472 [PubMed - indexed for MEDLINE]Related articles

    7.

    Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.

    Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E.

    Diabetes. 2008 Apr;57(4):967-79. Epub 2007 Dec 27.PMID: 18162507 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.

    Smidt K, Jessen N, Petersen AB, Larsen A, Magnusson N, Jeppesen JB, Stoltenberg M, Culvenor JG, Tsatsanis A, Brock B, Schmitz O, Wogensen L, Bush AI, Rungby J.

    PLoS One. 2009 May 25;4(5):e5684.PMID: 19492079 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.

    Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A.

    Diabetes. 2008 Apr;57(4):938-44. Epub 2008 Jan 2.PMID: 18171713 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip.

    Lin P, Chen L, Li D, Liu J, Yang N, Sun Y, Xu Y, Fu Y, Hou X.

    Tohoku J Exp Med. 2009 Jan;217(1):59-65.PMID: 19155609 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

    Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

    Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

    12.

    The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

    Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

    Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

    13.

    Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line.

    Leung KK, Leung PS.

    JOP. 2008 May 8;9(3):290-9.PMID: 18469441 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2.

    Kim SJ, Nian C, Widenmaier S, McIntosh CH.

    Mol Cell Biol. 2008 Mar;28(5):1644-56. Epub 2007 Dec 17.PMID: 18086876 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells.

    Raile K, Klammt J, Garten A, Laue S, Blüher M, Kralisch S, Klöting N, Kiess W.

    Regul Pept. 2006 Jul 15;135(1-2):30-8. Epub 2006 Apr 27.PMID: 16644033 [PubMed - indexed for MEDLINE]Related articles

    16.

    Stevioside improves pancreatic beta-cell function during glucotoxicity via regulation of acetyl-CoA carboxylase.

    Chen J, Jeppesen PB, Nordentoft I, Hermansen K.

    Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1906-16. Epub 2007 Mar 6.PMID: 17341549 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.

    Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ.

    J Biol Chem. 2005 Jan 21;280(3):2282-93. Epub 2004 Nov 9.PMID: 15537654 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    [Improvement of the function of islet beta and alpha cells by intervention against glucotoxicity: experiment with rats]

    He QH, Zhou YS, Wang Z, Wang S, Mou ZQ, Li J, Chi JM.

    Zhonghua Yi Xue Za Zhi. 2008 Feb 5;88(6):374-7. Chinese. PMID: 18581888 [PubMed - indexed for MEDLINE]Related articles

    19.

    Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

    Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

    Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.PMID: 17068144 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    TRI3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis.

    Qian B, Wang H, Men X, Zhang W, Cai H, Xu S, Xu Y, Ye L, Wollheim CB, Lou J.

    J Endocrinol. 2008 Dec;199(3):407-16. Epub 2008 Sep 25. Erratum in: J Endocrinol. 2009 Feb;200(2):243. PMID: 18818302 [PubMed - indexed for MEDLINE]Related articles

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