PubMed

Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.

Wong FS, Siew LK, Scott G, Thomas IJ, Chapman S, Viret C, Wen L.

Diabetes. 2009 May;58(5):1156-64. Epub 2009 Feb 10.PMID: 19208910 [PubMed - indexed for MEDLINE]Related articlesFree article

Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice.

Verdaguer J, Schmidt D, Amrani A, Anderson B, Averill N, Santamaria P.

J Exp Med. 1997 Nov 17;186(10):1663-76.PMID: 9362527 [PubMed - indexed for MEDLINE]Related articlesFree article

Thymic and postthymic regulation of diabetogenic CD8 T cell development in TCR transgenic nonobese diabetic (NOD) mice.

Kanagawa O, Shimizu J, Vaupel BA.

J Immunol. 2000 May 15;164(10):5466-73.PMID: 10799914 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetes.

Anderson B, Park BJ, Verdaguer J, Amrani A, Santamaria P.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9311-6.PMID: 10430939 [PubMed - indexed for MEDLINE]Related articlesFree article

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.

Grewal IS, Grewal KD, Wong FS, Picarella DE, Janeway CA Jr, Flavell RA.

J Exp Med. 1996 Nov 1;184(5):1963-74.PMID: 8920883 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic and therapeutic control of diabetogenic CD8+ T cells.

Santamaria P.

Novartis Found Symp. 2008;292:130-6; discussion 136-45, 202-3.PMID: 19209463 [PubMed - indexed for MEDLINE]Related articles

CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer.

Tarbell KV, Lee M, Ranheim E, Chao CC, Sanna M, Kim SK, Dickie P, Teyton L, Davis M, McDevitt H.

J Exp Med. 2002 Aug 19;196(4):481-92.PMID: 12186840 [PubMed - indexed for MEDLINE]Related articlesFree article

Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice.

Jun HS, Santamaria P, Lim HW, Zhang ML, Yoon JW.

Diabetes. 1999 Jan;48(1):34-42.PMID: 9892220 [PubMed - indexed for MEDLINE]Related articlesFree article

Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains.

Verdaguer J, Yoon JW, Anderson B, Averill N, Utsugi T, Park BJ, Santamaria P.

J Immunol. 1996 Nov 15;157(10):4726-35.PMID: 8906855 [PubMed - indexed for MEDLINE]Related articles

alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10.

Hammond KJ, Poulton LD, Palmisano LJ, Silveira PA, Godfrey DI, Baxter AG.

J Exp Med. 1998 Apr 6;187(7):1047-56.PMID: 9529321 [PubMed - indexed for MEDLINE]Related articlesFree article

Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.

Serreze DV, Choisy-Rossi CM, Grier AE, Holl TM, Chapman HD, Gahagan JR, Osborne MA, Zhang W, King BL, Brown A, Roopenian D, Marron MP.

J Immunol. 2008 Mar 1;180(5):3250-9.PMID: 18292549 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout.

Jasinski JM, Yu L, Nakayama M, Li MM, Lipes MA, Eisenbarth GS, Liu E.

Diabetes. 2006 Jul;55(7):1978-84.PMID: 16804066 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.

Graser RT, DiLorenzo TP, Wang F, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV.

J Immunol. 2000 Apr 1;164(7):3913-8.PMID: 10725754 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens.

Yamanouchi J, Verdaguer J, Han B, Amrani A, Serra P, Santamaria P.

J Immunol. 2003 Dec 15;171(12):6900-9.PMID: 14662897 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells.

Mukherjee R, Chaturvedi P, Qin HY, Singh B.

J Autoimmun. 2003 Nov;21(3):221-37.PMID: 14599847 [PubMed - indexed for MEDLINE]Related articles

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice.

Jarchum I, Baker JC, Yamada T, Takaki T, Marron MP, Serreze DV, DiLorenzo TP.

Diabetes. 2007 Oct;56(10):2551-60. Epub 2007 Jul 9.PMID: 17620420 [PubMed - indexed for MEDLINE]Related articlesFree article

RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytes.

Serra P, Amrani A, Han B, Yamanouchi J, Thiessen SJ, Santamaria P.

Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15566-71. Epub 2002 Nov 13.PMID: 12432095 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice.

Mora C, Grewal IS, Wong FS, Flavell RA.

Int Immunol. 2004 Feb;16(2):257-64.PMID: 14734611 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic administration of agonist peptide blocks the progression of spontaneous CD8-mediated autoimmune diabetes in transgenic mice without bystander damage.

Bercovici N, Heurtier A, Vizler C, Pardigon N, Cambouris C, Desreumaux P, Liblau R.

J Immunol. 2000 Jul 1;165(1):202-10.PMID: 10861053 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.

Amrani A, Verdaguer J, Anderson B, Utsugi T, Bou S, Santamaria P.

J Clin Invest. 1999 Apr;103(8):1201-9.PMID: 10207172 [PubMed - indexed for MEDLINE]Related articlesFree article