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    Results: 1 to 20 of 128

    1.

    Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction.

    Weiss A, Roscic A, Paganetti P.

    Mol Neurodegener. 2009 Feb 9;4:11.

    PMID:
    19203385
    [PubMed - in process]
    Free PMC Article
    2.

    Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.

    Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M.

    J Neurosci Res. 2010 Jan;88(1):179-90.

    PMID:
    19642201
    [PubMed - indexed for MEDLINE]
    3.

    Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

    Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.

    Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.

    PMID:
    10434303
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    4.

    Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

    Lee WC, Yoshihara M, Littleton JT.

    Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3224-9. Epub 2004 Feb 20.

    PMID:
    14978262
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    5.

    Induction of chemokines, MCP-1, and KC in the mutant huntingtin expressing neuronal cells because of proteasomal dysfunction.

    Godavarthi SK, Narender D, Mishra A, Goswami A, Rao SN, Nukina N, Jana NR.

    J Neurochem. 2009 Feb;108(3):787-95.

    PMID:
    19187096
    [PubMed - indexed for MEDLINE]
    6.

    Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease.

    Martin B, Golden E, Carlson OD, Pistell P, Zhou J, Kim W, Frank BP, Thomas S, Chadwick WA, Greig NH, Bates GP, Sathasivam K, Bernier M, Maudsley S, Mattson MP, Egan JM.

    Diabetes. 2009 Feb;58(2):318-28. Epub 2008 Nov 4.

    PMID:
    18984744
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    7.

    Huntingtin Aggregation Kinetics and their Pathological Role in a Drosophila Huntington's Disease Model.

    Weiss KR, Kimura Y, Lee WC, Littleton JT.

    Genetics. 2011 Nov 17. [Epub ahead of print]

    PMID:
    22095086
    [PubMed - as supplied by publisher]
    Free Article
    8.

    Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.

    Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R.

    Hum Mol Genet. 2007 Aug 1;16(15):1845-61. Epub 2007 May 21.

    PMID:
    17519223
    [PubMed - indexed for MEDLINE]
    Free Article
    9.

    Wild type Huntingtin reduces the cellular toxicity of mutant Huntingtin in mammalian cell models of Huntington's disease.

    Ho LW, Brown R, Maxwell M, Wyttenbach A, Rubinsztein DC.

    J Med Genet. 2001 Jul;38(7):450-2.

    PMID:
    11432963
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    10.

    Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease.

    Wyttenbach A, Swartz J, Kita H, Thykjaer T, Carmichael J, Bradley J, Brown R, Maxwell M, Schapira A, Orntoft TF, Kato K, Rubinsztein DC.

    Hum Mol Genet. 2001 Aug 15;10(17):1829-45.

    PMID:
    11532992
    [PubMed - indexed for MEDLINE]
    Free Article
    11.

    Huntingtin and its role in neuronal degeneration.

    Li SH, Li XJ.

    Neuroscientist. 2004 Oct;10(5):467-75. Review.

    PMID:
    15359012
    [PubMed - indexed for MEDLINE]
    12.

    A cellular model that recapitulates major pathogenic steps of Huntington's disease.

    Lunkes A, Mandel JL.

    Hum Mol Genet. 1998 Sep;7(9):1355-61.

    PMID:
    9700187
    [PubMed - indexed for MEDLINE]
    Free Article
    13.

    Selective neuronal degeneration in Huntington's disease.

    Cowan CM, Raymond LA.

    Curr Top Dev Biol. 2006;75:25-71. Review.

    PMID:
    16984809
    [PubMed - indexed for MEDLINE]
    14.

    Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation.

    Wang J, Gines S, MacDonald ME, Gusella JF.

    BMC Neurosci. 2005 Jan 13;6:1.

    PMID:
    15649316
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    15.

    Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease.

    Yu ZX, Li SH, Evans J, Pillarisetti A, Li H, Li XJ.

    J Neurosci. 2003 Mar 15;23(6):2193-202.

    PMID:
    12657678
    [PubMed - indexed for MEDLINE]
    Free Article
    16.

    Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

    Goswami A, Dikshit P, Mishra A, Mulherkar S, Nukina N, Jana NR.

    Biochem Biophys Res Commun. 2006 Mar 31;342(1):184-90. Epub 2006 Feb 3.

    PMID:
    16472774
    [PubMed - indexed for MEDLINE]
    17.

    Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease.

    Weiss A, Abramowski D, Bibel M, Bodner R, Chopra V, DiFiglia M, Fox J, Kegel K, Klein C, Grueninger S, Hersch S, Housman D, Régulier E, Rosas HD, Stefani M, Zeitlin S, Bilbe G, Paganetti P.

    Anal Biochem. 2009 Dec 1;395(1):8-15. Epub 2009 Aug 6.

    PMID:
    19664996
    [PubMed - indexed for MEDLINE]
    18.

    Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model.

    Roscic A, Baldo B, Crochemore C, Marcellin D, Paganetti P.

    J Neurochem. 2011 Oct;119(2):398-407. doi: 10.1111/j.1471-4159.2011.07435.x. Epub 2011 Sep 20.

    PMID:
    21854390
    [PubMed - indexed for MEDLINE]
    19.

    Does tissue transglutaminase play a role in Huntington's disease?

    Lesort M, Chun W, Tucholski J, Johnson GV.

    Neurochem Int. 2002 Jan;40(1):37-52. Review.

    PMID:
    11738471
    [PubMed - indexed for MEDLINE]
    20.

    Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.

    Huang CC, Faber PW, Persichetti F, Mittal V, Vonsattel JP, MacDonald ME, Gusella JF.

    Somat Cell Mol Genet. 1998 Jul;24(4):217-33.

    PMID:
    10410676
    [PubMed - indexed for MEDLINE]

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