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    Results: 1 to 20 of 88

    1.

    Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

    Cullen V, Lindfors M, Ng J, Paetau A, Swinton E, Kolodziej P, Boston H, Saftig P, Woulfe J, Feany MB, Myllykangas L, Schlossmacher MG, Tyynelä J.

    Mol Brain. 2009 Feb 9;2:5.

    PMID:
    19203374
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    2.

    Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.

    Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu Y, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J.

    Mol Brain. 2008 Nov 21;1:17.

    PMID:
    19021916
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    3.

    Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.

    Sevlever D, Jiang P, Yen SH.

    Biochemistry. 2008 Sep 9;47(36):9678-87. Epub 2008 Aug 15.

    PMID:
    18702517
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    4.

    Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.

    Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L.

    PLoS One. 2009;4(5):e5515. Epub 2009 May 13.

    PMID:
    19436756
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    5.

    Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.

    Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, Chesselet MF, Yang XW.

    J Neurosci. 2009 Feb 18;29(7):1962-76.

    PMID:
    19228951
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    6.

    Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

    Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH.

    Neurobiol Dis. 2009 Sep;35(3):385-98. Epub 2009 Jun 6.

    PMID:
    19505575
    [PubMed - indexed for MEDLINE]
    7.

    Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity.

    Liangliang X, Yonghui H, Shunmei E, Shoufang G, Wei Z, Jiangying Z.

    Mol Biol Rep. 2010 Apr;37(4):1875-81. Epub 2009 Jul 17.

    PMID:
    19609719
    [PubMed - indexed for MEDLINE]
    8.

    Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells.

    Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L.

    J Biol Chem. 2008 Aug 29;283(35):23542-56. Epub 2008 Jun 19.

    PMID:
    18566453
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    9.

    Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.

    Xun Z, Sowell RA, Kaufman TC, Clemmer DE.

    Mol Cell Proteomics. 2008 Jul;7(7):1191-203. Epub 2008 Mar 18.

    PMID:
    18353766
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    11.

    Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions.

    Ryo A, Togo T, Nakai T, Hirai A, Nishi M, Yamaguchi A, Suzuki K, Hirayasu Y, Kobayashi H, Perrem K, Liou YC, Aoki I.

    J Biol Chem. 2006 Feb 17;281(7):4117-25. Epub 2005 Dec 19.

    PMID:
    16365047
    [PubMed - indexed for MEDLINE]
    Free Article
    12.

    Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications.

    Qing H, Wong W, McGeer EG, McGeer PL.

    Biochem Biophys Res Commun. 2009 Sep 11;387(1):149-52. Epub 2009 Jul 1.

    PMID:
    19576176
    [PubMed - indexed for MEDLINE]
    14.

    Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.

    Du G, Liu X, Chen X, Song M, Yan Y, Jiao R, Wang CC.

    Mol Biol Cell. 2010 Jul 1;21(13):2128-37. Epub 2010 May 5.

    PMID:
    20444973
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    15.

    Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins.

    Grimm S, Ernst L, Grötzinger N, Höhn A, Breusing N, Reinheckel T, Grune T.

    Free Radic Res. 2010 Sep;44(9):1013-26.

    PMID:
    20560835
    [PubMed - indexed for MEDLINE]
    16.

    Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.

    Shaltiel-Karyo R, Frenkel-Pinter M, Egoz-Matia N, Frydman-Marom A, Shalev DE, Segal D, Gazit E.

    PLoS One. 2010 Nov 10;5(11):e13863.

    PMID:
    21085664
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    17.

    Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.

    Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT.

    Am J Pathol. 2007 May;170(5):1725-38.

    PMID:
    17456777
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    18.

    alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress.

    Sharma N, Brandis KA, Herrera SK, Johnson BE, Vaidya T, Shrestha R, Debburman SK.

    J Mol Neurosci. 2006;28(2):161-78.

    PMID:
    16679556
    [PubMed - indexed for MEDLINE]
    19.

    Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.

    Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E, Engelender S.

    J Biol Chem. 2008 Feb 8;283(6):3316-28. Epub 2007 Dec 10.

    PMID:
    18070888
    [PubMed - indexed for MEDLINE]
    Free Article
    20.

    Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.

    Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, Cuervo AM.

    J Clin Invest. 2008 Feb;118(2):777-88.

    PMID:
    18172548
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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