PubMed

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells.

da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA.

Diabetes. 2009 Apr;58(4):894-905. Epub 2009 Jan 23.PMID: 19168596 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells.

Loder MK, da Silva Xavier G, McDonald A, Rutter GA.

Biochem Soc Trans. 2008 Jun;36(Pt 3):357-9.PMID: 18481957 [PubMed - indexed for MEDLINE]Related articles

Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets.

Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K.

Diabetes. 2008 Mar;57(3):645-53. Epub 2007 Dec 10.PMID: 18071026 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.

Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K.

Hum Mol Genet. 2009 Jul 1;18(13):2388-99. Epub 2009 Apr 21.PMID: 19386626 [PubMed - indexed for MEDLINE]Related articles

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. Epub 2009 Jun 19.PMID: 19542200 [PubMed - indexed for MEDLINE]Related articles

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ.

Diabetes. 2007 Jul;56(7):1943-7. Epub 2007 Apr 6.PMID: 17416797 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc18c depletion selectively impairs the sustained phase of insulin release.

Oh E, Thurmond DC.

Diabetes. 2009 May;58(5):1165-74. Epub 2009 Feb 2.PMID: 19188424 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L.

J Clin Invest. 2007 Aug;117(8):2155-63.PMID: 17671651 [PubMed - indexed for MEDLINE]Related articlesFree article

Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function.

Kebede M, Favaloro J, Gunton JE, Laybutt DR, Shaw M, Wong N, Fam BC, Aston-Mourney K, Rantzau C, Zulli A, Proietto J, Andrikopoulos S.

Diabetes. 2008 Jul;57(7):1887-95. Epub 2008 Mar 28.PMID: 18375435 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function.

Gloyn AL, Braun M, Rorsman P.

Diabetes. 2009 Apr;58(4):800-2. No abstract available. PMID: 19336690 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.

Elbein SC, Chu WS, Das SK, Yao-Borengasser A, Hasstedt SJ, Wang H, Rasouli N, Kern PA.

Diabetologia. 2007 Aug;50(8):1621-30. Epub 2007 Jun 20.PMID: 17579832 [PubMed - indexed for MEDLINE]Related articles

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus.

Jin T, Liu L.

Mol Endocrinol. 2008 Nov;22(11):2383-92. Epub 2008 Jul 3. Review.PMID: 18599616 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

Schäfer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, 't Hart LM, Nijpels G, van Haeften TW, Häring HU, Fritsche A.

Diabetologia. 2007 Dec;50(12):2443-50. Epub 2007 Jul 28. Erratum in: Diabetologia. 2008 Jan;51(1):208. t' Hart, L M [corrected to 't Hart, L M]. Diabetologia. 2009 Mar;52(3):557. Dosage error in article text. PMID: 17661009 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.

Cauchi S, Meyre D, Dina C, Choquet H, Samson C, Gallina S, Balkau B, Charpentier G, Pattou F, Stetsyuk V, Scharfmann R, Staels B, Frühbeck G, Froguel P.

Diabetes. 2006 Oct;55(10):2903-8.PMID: 17003360 [PubMed - indexed for MEDLINE]Related articlesFree article

Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes.

Granhall C, Rosengren AH, Renström E, Luthman H.

Diabetes. 2006 Dec;55(12):3494-500.PMID: 17130497 [PubMed - indexed for MEDLINE]Related articlesFree article

Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines.

Kang Y, Huang X, Pasyk EA, Ji J, Holz GG, Wheeler MB, Tsushima RG, Gaisano HY.

Diabetologia. 2002 Feb;45(2):231-41.PMID: 11935155 [PubMed - indexed for MEDLINE]Related articles

Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats.

Rose T, Efendic S, Rupnik M.

J Gen Physiol. 2007 Jun;129(6):493-508.PMID: 17535961 [PubMed - indexed for MEDLINE]Related articlesFree article

Prime suspect: the TCF7L2 gene and type 2 diabetes risk.

Hattersley AT.

J Clin Invest. 2007 Aug;117(8):2077-9.PMID: 17671643 [PubMed - indexed for MEDLINE]Related articlesFree article