PubMed

Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD mice.

Valle A, Jofra T, Stabilini A, Atkinson M, Roncarolo MG, Battaglia M.

Diabetes. 2009 Apr;58(4):875-81. Epub 2009 Jan 16.PMID: 19151201 [PubMed - indexed for MEDLINE]Related articlesFree article

CD3 antibody treatment stimulates the functional capability of regulatory T cells.

Chatenoud L.

Novartis Found Symp. 2003;252:279-86; discussion 286-90. Review.PMID: 14609225 [PubMed - indexed for MEDLINE]Related articles

Anti-CD3 mAbs for treatment of type 1 diabetes.

Kaufman A, Herold KC.

Diabetes Metab Res Rev. 2009 May;25(4):302-6. Review.PMID: 19319985 [PubMed - indexed for MEDLINE]Related articles

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.

Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC.

Endocrinology. 2007 Nov;148(11):5136-44. Epub 2007 Aug 2.PMID: 17673522 [PubMed - indexed for MEDLINE]Related articlesFree article

CD3-specific antibody-induced active tolerance: from bench to bedside.

Chatenoud L.

Nat Rev Immunol. 2003 Feb;3(2):123-32. Review.PMID: 12563296 [PubMed - indexed for MEDLINE]Related articles

Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice.

Yang W, Hussain S, Mi QS, Santamaria P, Delovitch TL.

J Immunol. 2004 Oct 1;173(7):4407-16.PMID: 15383571 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential roles of TGF-beta in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells.

Chen G, Han G, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y.

J Leukoc Biol. 2008 Feb;83(2):280-7. Epub 2007 Nov 20.PMID: 18029395 [PubMed - indexed for MEDLINE]Related articlesFree article

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice.

Chatenoud L, Primo J, Bach JF.

J Immunol. 1997 Mar 15;158(6):2947-54.PMID: 9058834 [PubMed - indexed for MEDLINE]Related articles

Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab')2 treatment-reversed new-onset diabetes in nonobese diabetic mice.

Chen G, Han G, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y.

Am J Pathol. 2008 Apr;172(4):972-9. Epub 2008 Mar 18.PMID: 18349126 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced tumor necrosis factor in anti-CD3 antibody stimulated diabetic NOD mice: modulation by PGE1 and dietary lipid.

Barel D, Brennan DC, Jevnikar AM, Bastos M, Strom TB, Kelley VR.

Autoimmunity. 1992;13(2):141-9.PMID: 1467435 [PubMed - indexed for MEDLINE]Related articles

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

Chatenoud L, Thervet E, Primo J, Bach JF.

Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):123-7.PMID: 8278351 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody.

Molano RD, Pileggi A, Berney T, Poggioli R, Zahr E, Oliver R, Malek TR, Ricordi C, Inverardi L.

Transplantation. 2003 Jun 15;75(11):1812-9.PMID: 12811239 [PubMed - indexed for MEDLINE]Related articles

Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.

Battaglia M, Stabilini A, Draghici E, Gregori S, Mocchetti C, Bonifacio E, Roncarolo MG.

Diabetes. 2006 Jan;55(1):40-9.PMID: 16380475 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms mediating anti-CD3 antibody efficacy: insights from a mathematical model of type 1 diabetes.

Young DL, Ramanujan S, Kreuwel HT, Whiting CC, Gadkar KG, Shoda LK.

Ann N Y Acad Sci. 2006 Oct;1079:369-73.PMID: 17130581 [PubMed - indexed for MEDLINE]Related articles

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

Belghith M, Bluestone JA, Barriot S, Mégret J, Bach JF, Chatenoud L.

Nat Med. 2003 Sep;9(9):1202-8. Epub 2003 Aug 24.PMID: 12937416 [PubMed - indexed for MEDLINE]Related articles

Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis.

Zipris D, Lazarus AH, Crow AR, Hadzija M, Delovitch TL.

J Immunol. 1991 Jun 1;146(11):3763-71.PMID: 1827815 [PubMed - indexed for MEDLINE]Related articles

Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass.

Waldron-Lynch F, von Herrath M, Herold KC.

Novartis Found Symp. 2008;292:146-55; discussion 155-8, 202-3.PMID: 19203097 [PubMed - indexed for MEDLINE]Related articles

Nondepleting anti-CD4 and soluble interleukin-1 receptor prevent autoimmune destruction of syngeneic islet grafts in diabetic NOD mice.

Drage M, Zaccone P, Phillips JM, Nicoletti F, Dawson J, Andrew Bradley J, Cooke A.

Transplantation. 2002 Sep 15;74(5):611-9.PMID: 12352875 [PubMed - indexed for MEDLINE]Related articles

Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies.

Mottram PL, Murray-Segal LJ, Han W, Maguire J, Stein-Oakley AN.

Transpl Immunol. 2002 Jun;10(1):63-72.PMID: 12182467 [PubMed - indexed for MEDLINE]Related articles

Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation.

Xu H, Montgomery SP, Preston EH, Tadaki DK, Hale DA, Harlan DM, Kirk AD.

J Immunol. 2003 Mar 1;170(5):2776-82.PMID: 12594309 [PubMed - indexed for MEDLINE]Related articlesFree article