Warning: The NCBI web site requires JavaScript to function. more...
Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo.
Homann S, Tibroni N, Baumann I, Sertel S, Keppler OT, Fackler OT.
Retrovirology. 2009 Jan 15;6:6.
Related citations
Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.
Glushakova S, Grivel JC, Suryanarayana K, Meylan P, Lifson JD, Desrosiers R, Margolis L.
J Virol. 1999 May;73(5):3968-74.
CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo.
Glushakova S, Münch J, Carl S, Greenough TC, Sullivan JL, Margolis L, Kirchhoff F.
J Virol. 2001 Nov;75(21):10113-7.
Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo.
Choi J, Walker J, Boichuk S, Kirkiles-Smith N, Torpey N, Pober JS, Alexander L.
J Virol. 2005 Jan;79(1):264-76.
Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.
Schindler M, Rajan D, Specht A, Ritter C, Pulkkinen K, Saksela K, Kirchhoff F.
J Virol. 2007 Dec;81(23):13005-14. Epub 2007 Sep 19.
Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo.
Rücker E, Grivel JC, Münch J, Kirchhoff F, Margolis L.
J Virol. 2004 Nov;78(22):12689-93.
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes.
Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C.
J Virol. 2002 May;76(9):4625-33.
The role of upstream U3 sequences in HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo.
Münch J, Rajan D, Rücker E, Wildum S, Adam N, Kirchhoff F.
Virology. 2005 Oct 25;341(2):313-20. Epub 2005 Aug 15.
Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2.
Olivieri KC, Mukerji J, Gabuzda D.
Retrovirology. 2011 Aug 5;8:64.
Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells?
Azad AA.
Biochem Biophys Res Commun. 2000 Jan 27;267(3):677-85. Review.
Functional characterization of HIV-1 Nef mutants in the context of viral infection.
Fackler OT, Moris A, Tibroni N, Giese SI, Glass B, Schwartz O, Kräusslich HG.
Virology. 2006 Aug 1;351(2):322-39. Epub 2006 May 8.
T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS.
Alessandrini L, Santarcangelo AC, Olivetta E, Ferrantelli F, d'Aloja P, Pugliese K, Pelosi E, Chelucci C, Mattia G, Peschle C, Verani P, Federico M.
J Gen Virol. 2000 Dec;81(Pt 12):2905-17.
Internalization and intracellular retention of CD4 are two separate functions of the human immunodeficiency virus type 1 Nef protein.
Giolo G, Neri F, Casartelli N, Potestà M, Belleudi F, Torrisi MR, Doria M.
J Gen Virol. 2007 Nov;88(Pt 11):3133-8.
The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.
Miller MD, Warmerdam MT, Gaston I, Greene WC, Feinberg MB.
J Exp Med. 1994 Jan 1;179(1):101-13.
Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.
Kawano Y, Tanaka Y, Misawa N, Tanaka R, Kira JI, Kimura T, Fukushi M, Sano K, Goto T, Nakai M, Kobayashi T, Yamamoto N, Koyanagi Y.
J Virol. 1997 Nov;71(11):8456-66.
Resistance to apoptosis in HIV-infected CD4+ T lymphocytes is mediated by macrophages: role for Nef and immune activation in viral persistence.
Mahlknecht U, Deng C, Lu MC, Greenough TC, Sullivan JL, O'Brien WA, Herbein G.
J Immunol. 2000 Dec 1;165(11):6437-46.
Strong ability of Nef-specific CD4+ cytotoxic T cells to suppress human immunodeficiency virus type 1 (HIV-1) replication in HIV-1-infected CD4+ T cells and macrophages.
Zheng N, Fujiwara M, Ueno T, Oka S, Takiguchi M.
J Virol. 2009 Aug;83(15):7668-77. Epub 2009 May 20.
HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice.
Hanna Z, Priceputu E, Hu C, Vincent P, Jolicoeur P.
Virology. 2006 Mar 1;346(1):40-52. Epub 2005 Nov 28.
Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses.
Münch J, Rajan D, Schindler M, Specht A, Rücker E, Novembre FJ, Nerrienet E, Müller-Trutwin MC, Peeters M, Hahn BH, Kirchhoff F.
J Virol. 2007 Dec;81(24):13852-64. Epub 2007 Oct 10.
Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.
Keppler OT, Tibroni N, Venzke S, Rauch S, Fackler OT.
J Leukoc Biol. 2006 Mar;79(3):616-27. Epub 2005 Dec 19.
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on