PubMed

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.

Escribano O, Guillén C, Nevado C, Gómez-Hernández A, Kahn CR, Benito M.

Diabetes. 2009 Apr;58(4):820-8. Epub 2009 Jan 9.PMID: 19136656 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.

Asghar Z, Yau D, Chan F, Leroith D, Chan CB, Wheeler MB.

Diabetologia. 2006 Jan;49(1):90-9. Epub 2005 Dec 15. Erratum in: Diabetologia. 2006 Mar;49(3):614. PMID: 16362284 [PubMed - indexed for MEDLINE]Related articles

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8977-82. Epub 2007 Apr 6.PMID: 17416680 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.

J Clin Invest. 2000 Mar;105(6):731-40.PMID: 10727441 [PubMed - indexed for MEDLINE]Related articlesFree article

Does IGF-I stimulate pancreatic islet cell growth?

Liu JL.

Cell Biochem Biophys. 2007;48(2-3):115-25.PMID: 17709881 [PubMed - indexed for MEDLINE]Related articles

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T.

J Clin Invest. 2007 Jan;117(1):246-57.PMID: 17200721 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance.

Okamoto H, Hribal ML, Lin HV, Bennett WR, Ward A, Accili D.

J Clin Invest. 2006 Mar;116(3):775-82. Epub 2006 Feb 16.PMID: 16485043 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.

J Biol Chem. 2006 Feb 24;281(8):5246-57. Epub 2005 Dec 23.PMID: 16377800 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes?

Sesti G.

Ann Med. 2002;34(6):444-50. Review.PMID: 12523500 [PubMed - indexed for MEDLINE]Related articles

Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice.

Robertson K, Kopchick JJ, Liu JL.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E491-8. Epub 2006 Apr 18.PMID: 16621895 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetes.

Villafuerte BC, Barati MT, Song Y, Moore JP, Epstein PN, Portillo J.

Endocrinology. 2009 Jun;150(6):2611-7. Epub 2009 Feb 12.PMID: 19213832 [PubMed - indexed for MEDLINE]Related articles

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ.

Diabetologia. 2007 Jun;50(6):1248-56. Epub 2007 Mar 29.PMID: 17393136 [PubMed - indexed for MEDLINE]Related articles

Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.

Petrik J, Pell JM, Arany E, McDonald TJ, Dean WL, Reik W, Hill DJ.

Endocrinology. 1999 May;140(5):2353-63.PMID: 10218989 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance and increased pancreatic beta-cell proliferation in mice expressing a mutant insulin receptor (P1195L).

Ogino J, Sakurai K, Yoshiwara K, Suzuki Y, Ishizuka N, Seki N, Suzuki Y, Koseki H, Shirasawa T, Hashimoto N, Yagui K, Saito Y.

J Endocrinol. 2006 Sep;190(3):739-47.PMID: 17003275 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D.

J Clin Invest. 2000 Jan;105(2):199-205.PMID: 10642598 [PubMed - indexed for MEDLINE]Related articlesFree article

A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes.

Robertson K, Lu Y, De Jesus K, Li B, Su Q, Lund PK, Liu JL.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E928-38. Epub 2008 Feb 12.PMID: 18270301 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes.

Fernández AM, Kim JK, Yakar S, Dupont J, Hernandez-Sanchez C, Castle AL, Filmore J, Shulman GI, Le Roith D.

Genes Dev. 2001 Aug 1;15(15):1926-34.PMID: 11485987 [PubMed - indexed for MEDLINE]Related articlesFree article

Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance.

Takamoto I, Terauchi Y, Kubota N, Ohsugi M, Ueki K, Kadowaki T.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:147-56.PMID: 18834442 [PubMed - indexed for MEDLINE]Related articles

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR.

Diabetes. 2000 Dec;49(12):2126-34.PMID: 11118016 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article