PubMed

Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.

Hwang JH, Kim DW, Jo EJ, Kim YK, Jo YS, Park JH, Yoo SK, Park MK, Kwak TH, Kho YL, Han J, Choi HS, Lee SH, Kim JM, Lee I, Kyung T, Jang C, Chung J, Kweon GR, Shong M.

Diabetes. 2009 Apr;58(4):965-74. Epub 2009 Jan 9.PMID: 19136651 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.

Kim SY, Jeoung NH, Oh CJ, Choi YK, Lee HJ, Kim HJ, Kim JY, Hwang JH, Tadi S, Yim YH, Lee KU, Park KG, Huh S, Min KN, Jeong KH, Park MG, Kwak TH, Kweon GR, Inukai K, Shong M, Lee IK.

Circ Res. 2009 Apr 10;104(7):842-50. Epub 2009 Feb 19.PMID: 19229058 [PubMed - indexed for MEDLINE]Related articles

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity.

Thupari JN, Landree LE, Ronnett GV, Kuhajda FP.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. Epub 2002 Jun 11.PMID: 12060712 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic benefits from Sirt1 and Sirt1 activators.

Chaudhary N, Pfluger PT.

Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):431-7. Review.PMID: 19474719 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha.

Cha SH, Rodgers JT, Puigserver P, Chohnan S, Lane MD.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15410-5. Epub 2006 Oct 9.PMID: 17030788 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.

Ahn KS, Sethi G, Jain AK, Jaiswal AK, Aggarwal BB.

J Biol Chem. 2006 Jul 21;281(29):19798-808. Epub 2006 May 8.PMID: 16682409 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome.

Kusunoki J, Kanatani A, Moller DE.

Endocrine. 2006 Feb;29(1):91-100. Review.PMID: 16622296 [PubMed - indexed for MEDLINE]Related articles

In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue.

Gaikwad A, Long DJ 2nd, Stringer JL, Jaiswal AK.

J Biol Chem. 2001 Jun 22;276(25):22559-64. Epub 2001 Apr 17.PMID: 11309386 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase as a new drug target for obesity treatment.

Dobrzyn A, Ntambi JM.

Obes Rev. 2005 May;6(2):169-74. Review.PMID: 15836467 [PubMed - indexed for MEDLINE]Related articles

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6409-14. Epub 2004 Apr 19.PMID: 15096593 [PubMed - indexed for MEDLINE]Related articlesFree article

Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis.

Iskander K, Gaikwad A, Paquet M, Long DJ 2nd, Brayton C, Barrios R, Jaiswal AK.

Cancer Res. 2005 Mar 15;65(6):2054-8.PMID: 15781611 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.

Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, Vonderfecht S, Hecht R, Li YS, Lindberg RA, Chen JL, Jung DY, Zhang Z, Ko HJ, Kim JK, Véniant MM.

Diabetes. 2009 Jan;58(1):250-9. Epub 2008 Oct 7.PMID: 18840786 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.

Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS.

Diabetes. 2006 Jul;55(7):1915-22.PMID: 16804058 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.

Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J.

Cell Metab. 2008 Nov;8(5):347-58. Erratum in: Cell Metab. 2009 Feb;9(2):210. PMID: 19046567 [PubMed - indexed for MEDLINE]Related articles

Stearoyl-CoA desaturase-1 and the metabolic syndrome.

Cohen P, Ntambi JM, Friedman JM.

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):271-80. Review.PMID: 14683458 [PubMed - indexed for MEDLINE]Related articles

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm.

Matschinsky FM.

Diabetes. 1996 Feb;45(2):223-41. Review.PMID: 8549869 [PubMed - indexed for MEDLINE]Related articles

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

Hansford RG.

J Biol Chem. 1976 Sep 25;251(18):5483-9.PMID: 184082 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.

Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, Stanley WC.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H954-60. Epub 2007 Dec 14.PMID: 18083904 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.

Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB.

J Biol Chem. 2006 Jul 14;281(28):18933-41. Epub 2006 May 10.PMID: 16687413 [PubMed - indexed for MEDLINE]Related articlesFree article

Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs.

Zhou L, Cabrera ME, Huang H, Yuan CL, Monika DK, Sharma N, Bian F, Stanley WC.

J Physiol. 2007 Mar 15;579(Pt 3):811-21. Epub 2006 Dec 21.PMID: 17185335 [PubMed - indexed for MEDLINE]Related articlesFree article