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    Results: 1 to 20 of 2327

    1.

    Phosphoinositide 3-kinase targeting by the beta galactoside binding protein cytokine negates akt gene expression and leads aggressive breast cancer cells to apoptotic death.

    Wells V, Mallucci L.

    Breast Cancer Res. 2009;11(1):R2. Epub 2009 Jan 8.

    PMID:
    19133120
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    2.

    Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells.

    Marty B, Maire V, Gravier E, Rigaill G, Vincent-Salomon A, Kappler M, Lebigot I, Djelti F, Tourdès A, Gestraud P, Hupé P, Barillot E, Cruzalegui F, Tucker GC, Stern MH, Thiery JP, Hickman JA, Dubois T.

    Breast Cancer Res. 2008;10(6):R101. Epub 2008 Dec 3.

    PMID:
    19055754
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    3.

    Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway.

    Way TD, Kao MC, Lin JK.

    J Biol Chem. 2004 Feb 6;279(6):4479-89. Epub 2003 Nov 5.

    PMID:
    14602723
    [PubMed - indexed for MEDLINE]
    Free Article

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    4.

    Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis.

    Adya R, Tan BK, Punn A, Chen J, Randeva HS.

    Cardiovasc Res. 2008 May 1;78(2):356-65. Epub 2007 Dec 18.

    PMID:
    18093986
    [PubMed - indexed for MEDLINE]
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    5.

    Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification.

    Ram TG, Ethier SP.

    Cell Growth Differ. 1996 May;7(5):551-61.

    PMID:
    8732665
    [PubMed - indexed for MEDLINE]
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    6.

    Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

    McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

    Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

    PMID:
    16854453
    [PubMed - indexed for MEDLINE]

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    7.

    Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis.

    Dey JH, Bianchi F, Voshol J, Bonenfant D, Oakeley EJ, Hynes NE.

    Cancer Res. 2010 May 15;70(10):4151-62. Epub 2010 May 11.

    PMID:
    20460524
    [PubMed - indexed for MEDLINE]
    Free Article

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    8.

    Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells.

    Asanuma H, Torigoe T, Kamiguchi K, Hirohashi Y, Ohmura T, Hirata K, Sato M, Sato N.

    Cancer Res. 2005 Dec 1;65(23):11018-25.

    PMID:
    16322251
    [PubMed - indexed for MEDLINE]
    Free Article

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    9.

    Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells.

    Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, Damodaran C.

    Int J Cancer. 2009 Aug 15;125(4):961-7.

    PMID:
    19384950
    [PubMed - indexed for MEDLINE]

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    10.

    Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.

    Menendez JA, Mehmi I, Verma VA, Teng PK, Lupu R.

    Mol Carcinog. 2004 Nov;41(3):164-78.

    PMID:
    15390078
    [PubMed - indexed for MEDLINE]

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    11.

    Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.

    Serova M, Ghoul A, Benhadji KA, Faivre S, Le Tourneau C, Cvitkovic E, Lokiec F, Lord J, Ogbourne SM, Calvo F, Raymond E.

    Mol Cancer Ther. 2008 Apr;7(4):915-22.

    PMID:
    18413805
    [PubMed - indexed for MEDLINE]
    Free Article

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    12.

    Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase.

    Tan M, Grijalva R, Yu D.

    Cancer Res. 1999 Apr 1;59(7):1620-5.

    PMID:
    10197638
    [PubMed - indexed for MEDLINE]
    Free Article

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    13.

    Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.

    Menendez JA, Vellon L, Colomer R, Lupu R.

    Int J Cancer. 2005 May 20;115(1):19-35.

    PMID:
    15657900
    [PubMed - indexed for MEDLINE]

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    14.

    Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.

    Nencioni A, Cea M, Garuti A, Passalacqua M, Raffaghello L, Soncini D, Moran E, Zoppoli G, Pistoia V, Patrone F, Ballestrero A.

    PLoS One. 2010 Feb 2;5(2):e9024.

    PMID:
    20126311
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    15.

    Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells.

    Papa V, Tazzari PL, Chiarini F, Cappellini A, Ricci F, Billi AM, Evangelisti C, Ottaviani E, Martinelli G, Testoni N, McCubrey JA, Martelli AM.

    Leukemia. 2008 Jan;22(1):147-60. Epub 2007 Oct 11.

    PMID:
    17928881
    [PubMed - indexed for MEDLINE]

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    16.

    Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway.

    Ariazi EA, Kraus RJ, Farrell ML, Jordan VC, Mertz JE.

    Mol Cancer Res. 2007 Jan;5(1):71-85.

    PMID:
    17259347
    [PubMed - indexed for MEDLINE]
    Free Article

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    17.

    Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways.

    Siddiqa A, Long LM, Li L, Marciniak RA, Kazhdan I.

    BMC Cancer. 2008 May 2;8:129.

    PMID:
    18454859
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    18.

    Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells.

    Kim KK, Lee JJ, Yang Y, You KH, Lee JH.

    Carcinogenesis. 2008 Apr;29(4):704-12. Epub 2008 Feb 6.

    PMID:
    18258606
    [PubMed - indexed for MEDLINE]
    Free Article

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    19.

    The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells.

    Barbacci EG, Pustilnik LR, Rossi AM, Emerson E, Miller PE, Boscoe BP, Cox ED, Iwata KK, Jani JP, Provoncha K, Kath JC, Liu Z, Moyer JD.

    Cancer Res. 2003 Aug 1;63(15):4450-9.

    PMID:
    12907618
    [PubMed - indexed for MEDLINE]
    Free Article

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    20.

    Heregulin beta1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells.

    Hutcheson IR, Knowlden JM, Hiscox SE, Barrow D, Gee JM, Robertson JF, Ellis IO, Nicholson RI.

    Breast Cancer Res. 2007;9(4):R50.

    PMID:
    17686159
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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