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Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation.

Bulloj A, Leal MC, Surace EI, Zhang X, Xu H, Ledesma MD, Castaño EM, Morelli L.

Mol Neurodegener. 2008 Dec 31;3:22.PMID: 19117523 [PubMed - in process]Related articlesFree article

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.

J Neurosci. 2000 Mar 1;20(5):1657-65.PMID: 10684867 [PubMed - indexed for MEDLINE]Related articlesFree article

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.

Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ.

Am J Pathol. 2004 Apr;164(4):1425-34.PMID: 15039230 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12.PMID: 12634421 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.

J Biol Chem. 1998 Dec 4;273(49):32730-8.PMID: 9830016 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-beta Degrading Protease.

Bulloj A, Leal MC, Xu H, Castaño EM, Morelli L.

J Alzheimers Dis. 2009 Sep 11. [Epub ahead of print]PMID: 19749427 [PubMed - as supplied by publisher]Related articles

Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease.

Bulloj A, Leal MC, Xu H, Castaño EM, Morelli L.

J Alzheimers Dis. 2010 Jan;19(1):79-95.PMID: 20061628 [PubMed - in process]Related articles

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM.

J Neurosci. 2004 Dec 8;24(49):11120-6.PMID: 15590928 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.

Morelli L, Llovera RE, Mathov I, Lue LF, Frangione B, Ghiso J, Castaño EM.

J Biol Chem. 2004 Dec 31;279(53):56004-13. Epub 2004 Oct 15.PMID: 15489232 [PubMed - indexed for MEDLINE]Related articlesFree article

The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis.

Llovera RE, de Tullio M, Alonso LG, Leissring MA, Kaufman SB, Roher AE, de Prat Gay G, Morelli L, Castaño EM.

J Biol Chem. 2008 Jun 20;283(25):17039-48. Epub 2008 Apr 14.PMID: 18411275 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure.

Behl M, Zhang Y, Zheng W.

Cerebrospinal Fluid Res. 2009 Sep 11;6:11.PMID: 19747378 [PubMed - in process]Related articlesFree article

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.

Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.

Biochemistry. 2005 May 3;44(17):6513-25.PMID: 15850385 [PubMed - indexed for MEDLINE]Related articles

GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.PMID: 19355846 [PubMed - indexed for MEDLINE]Related articles

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures.

Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE.

J Neurosci Res. 2006 May 15;83(7):1262-70.PMID: 16511862 [PubMed - indexed for MEDLINE]Related articles

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders.

Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM.

Neurobiol Aging. 2005 May;26(5):645-54.PMID: 15708439 [PubMed - indexed for MEDLINE]Related articles

Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease.

Jaya Prasanthi RP, Schommer E, Thomasson S, Thompson A, Feist G, Ghribi O.

Mech Ageing Dev. 2008 Nov;129(11):649-55. Epub 2008 Sep 19.PMID: 18845178 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease.

Dorfman VB, Pasquini L, Riudavets M, López-Costa JJ, Villegas A, Troncoso JC, Lopera F, Castaño EM, Morelli L.

Neurobiol Aging. 2008 Nov 17. [Epub ahead of print]PMID: 19019493 [PubMed - as supplied by publisher]Related articles

17beta-Estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: Relevance to Alzheimer's prevention.

Zhao L, Yao J, Mao Z, Chen S, Wang Y, Brinton RD.

Neurobiol Aging. 2010 Jan 4. [Epub ahead of print]PMID: 20053478 [PubMed - as supplied by publisher]Related articles

IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.

Shimizu E, Kawahara K, Kajizono M, Sawada M, Nakayama H.

J Immunol. 2008 Nov 1;181(9):6503-13.PMID: 18941241 [PubMed - indexed for MEDLINE]Related articlesFree article

Abeta-degrading enzymes in Alzheimer's disease.

Miners JS, Baig S, Palmer J, Palmer LE, Kehoe PG, Love S.

Brain Pathol. 2008 Apr;18(2):240-52. Review.PMID: 18363935 [PubMed - indexed for MEDLINE]Related articles