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    Results: 1 to 20 of 101

    1.

    Targeting hepatic glucokinase in type 2 diabetes: weighing the benefits and risks.

    Agius L.

    Diabetes. 2009 Jan;58(1):18-20. No abstract available. PMID: 19114725 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.

    Torres TP, Catlin RL, Chan R, Fujimoto Y, Sasaki N, Printz RL, Newgard CB, Shiota M.

    Diabetes. 2009 Jan;58(1):78-86. Epub 2008 Oct 24.PMID: 18952838 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    For the ZDF rat, "Breaking up is hard to do": dissociation of the GK:GKRP complex.

    Lange AJ.

    Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1379-80. Epub 2006 Dec 21. No abstract available. PMID: 17185403 [PubMed - indexed for MEDLINE]Related articles

    4.

    A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes.

    Shin JS, Torres TP, Catlin RL, Donahue EP, Shiota M.

    Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1381-90. Epub 2007 Jan 4.PMID: 17204595 [PubMed - indexed for MEDLINE]Related articles

    5.

    Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats.

    Fujimoto Y, Torres TP, Donahue EP, Shiota M.

    Diabetes. 2006 Sep;55(9):2479-90.PMID: 16936196 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Defect in glucokinase translocation in Zucker diabetic fatty rats.

    Fujimoto Y, Donahue EP, Shiota M.

    Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.PMID: 15138155 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Allosteric activators of glucokinase: potential role in diabetes therapy.

    Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.

    Science. 2003 Jul 18;301(5631):370-3.PMID: 12869762 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    [New aspects of pancreatic beta cell functions and their possible therapeutic applications]

    Tiedge M.

    Dtsch Med Wochenschr. 2006 Dec;131 Suppl 8:S226-30. Review. German. PMID: 17139575 [PubMed - indexed for MEDLINE]Related articles

    9.

    Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats.

    Seoane J, Barberà A, Télémaque-Potts S, Newgard CB, Guinovart JJ.

    J Biol Chem. 1999 Nov 5;274(45):31833-8.PMID: 10542207 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte.

    de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L.

    J Biol Chem. 2000 Apr 7;275(14):10597-603.PMID: 10744755 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.

    Morral N, McEvoy R, Dong H, Meseck M, Altomonte J, Thung S, Woo SL.

    Hum Gene Ther. 2002 Sep 1;13(13):1561-70.PMID: 12228011 [PubMed - indexed for MEDLINE]Related articles

    12.

    Medicine. Drug deals diabetes a one-two punch.

    Couzin J.

    Science. 2003 Jul 18;301(5631):290. No abstract available. PMID: 12869732 [PubMed - indexed for MEDLINE]Related articles

    13.

    Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.

    Wang MY, Koyama K, Shimabukuro M, Mangelsdorf D, Newgard CB, Unger RH.

    Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11921-6.PMID: 9751766 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Effects of altered glucokinase gene copy number on blood glucose homoeostasis.

    Niswender KD, Postic C, Shiota M, Jetton TL, Magnuson MA.

    Biochem Soc Trans. 1997 Feb;25(1):113-7. Review. No abstract available. PMID: 9056854 [PubMed - indexed for MEDLINE]Related articles

    15.

    An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.

    Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.

    J Biol Chem. 2006 Dec 8;281(49):37668-74. Epub 2006 Oct 6.PMID: 17028192 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs.

    Zhang YL, Tan XH, Xiao MF, Li H, Mao YQ, Yang X, Tan HR.

    Acta Pharmacol Sin. 2004 Dec;25(12):1659-65.PMID: 15569412 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Glucokinase, glucose homeostasis, and diabetes mellitus.

    Matschinsky FM.

    Curr Diab Rep. 2005 Jun;5(3):171-6. Review.PMID: 15929862 [PubMed - indexed for MEDLINE]Related articles

    18.

    Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

    Matschinsky F, Liang Y, Kesavan P, Wang L, Froguel P, Velho G, Cohen D, Permutt MA, Tanizawa Y, Jetton TL, et al.

    J Clin Invest. 1993 Nov;92(5):2092-8. Review. No abstract available. PMID: 8227324 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Two birds with one stone: novel glucokinase activator stimulates glucose-induced pancreatic insulin secretion and augments hepatic glucose metabolism.

    Al-Hasani H, Tschöp MH, Cushman SW.

    Mol Interv. 2003 Oct;3(7):367-70. Review.PMID: 14993457 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression.

    Desai UJ, Slosberg ED, Boettcher BR, Caplan SL, Fanelli B, Stephan Z, Gunther VJ, Kaleko M, Connelly S.

    Diabetes. 2001 Oct;50(10):2287-95.PMID: 11574410 [PubMed - indexed for MEDLINE]Related articlesFree article

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