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Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?

Stewart PM, Tomlinson JW.

Diabetes. 2009 Jan;58(1):14-5. No abstract available. PMID: 19114723 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-hydroxysteroid dehydrogenase type 1 and obesity.

Morton NM, Seckl JR.

Front Horm Res. 2008;36:146-64. Review.PMID: 18230901 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.

Masuzaki H, Flier JS.

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62. Review.PMID: 14683456 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific Cushing's syndrome uncovers a new target in treating the metabolic syndrome--11beta-hydroxysteroid dehydrogenase type 1.

Stewart PM.

Clin Med. 2005 Mar-Apr;5(2):142-6. Review. No abstract available. PMID: 15847006 [PubMed - indexed for MEDLINE]Related articles

Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning.

Walker BR.

Proc Nutr Soc. 2007 Feb;66(1):1-8.PMID: 17343766 [PubMed - indexed for MEDLINE]Related articles

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target.

Wamil M, Seckl JR.

Drug Discov Today. 2007 Jul;12(13-14):504-20. Epub 2007 Jun 27. Review.PMID: 17631244 [PubMed - indexed for MEDLINE]Related articles

Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice.

Nuotio-Antar AM, Hachey DL, Hasty AH.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1517-28. Epub 2007 Sep 18. Erratum in: Am J Physiol Endocrinol Metab. 2008 May;294(5):E993. PMID: 17878220 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease.

Walker BR, Andrew R.

Ann N Y Acad Sci. 2006 Nov;1083:165-84. Review.PMID: 17148739 [PubMed - indexed for MEDLINE]Related articles

11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity.

Hughes KA, Webster SP, Walker BR.

Expert Opin Investig Drugs. 2008 Apr;17(4):481-96. Review.PMID: 18363514 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue expression of 11beta-hydroxysteroid dehydrogenase type 1 in Cushing's syndrome and in obesity.

Espíndola-Antunes D, Kater CE.

Arq Bras Endocrinol Metabol. 2007 Nov;51(8):1397-403.PMID: 18209879 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for metabolic syndrome.

Schnackenberg CG.

Curr Opin Investig Drugs. 2008 Mar;9(3):295-300. Review.PMID: 18311666 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for the treatment of metabolic syndrome.

Wang M.

Curr Opin Investig Drugs. 2006 Apr;7(4):319-23. Review.PMID: 16625818 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of 11beta-HSD1: a potential treatment for the metabolic syndrome.

St Jean DJ Jr, Wang M, Fotsch C.

Curr Top Med Chem. 2008;8(17):1508-23. Review.PMID: 19075762 [PubMed - indexed for MEDLINE]Related articles

11 beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.

Wake DJ, Walker BR.

Mol Cell Endocrinol. 2004 Feb 27;215(1-2):45-54. Review.PMID: 15026174 [PubMed - indexed for MEDLINE]Related articles

2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.

Johansson L, Fotsch C, Bartberger MD, Castro VM, Chen M, Emery M, Gustafsson S, Hale C, Hickman D, Homan E, Jordan SR, Komorowski R, Li A, McRae K, Moniz G, Matsumoto G, Orihuela C, Palm G, Veniant M, Wang M, Williams M, Zhang J.

J Med Chem. 2008 May 22;51(10):2933-43. Epub 2008 Apr 18.PMID: 18419108 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.

Stimson RH, Walker BR.

Minerva Endocrinol. 2007 Sep;32(3):141-59. Review.PMID: 17912154 [PubMed - indexed for MEDLINE]Related articles

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.

Tomlinson JW.

Minerva Endocrinol. 2005 Mar;30(1):37-46. Review.PMID: 15877012 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.

Tomlinson JW, Stewart PM.

Nat Clin Pract Endocrinol Metab. 2005 Dec;1(2):92-9. Review.PMID: 16929377 [PubMed - indexed for MEDLINE]Related articles

Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.

Stimson RH, Andersson J, Andrew R, Redhead DN, Karpe F, Hayes PC, Olsson T, Walker BR.

Diabetes. 2009 Jan;58(1):46-53. Epub 2008 Oct 13.PMID: 18852329 [PubMed - indexed for MEDLINE]Related articlesFree article

Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Olson S, Aster SD, Brown K, Carbin L, Graham DW, Hermanowski-Vosatka A, LeGrand CB, Mundt SS, Robbins MA, Schaeffer JM, Slossberg LH, Szymonifka MJ, Thieringer R, Wright SD, Balkovec JM.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4359-62.PMID: 16039856 [PubMed - indexed for MEDLINE]Related articles