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tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO).

Menendez JA, Vazquez-Martin A, Garcia-Villalba R, Carrasco-Pancorbo A, Oliveras-Ferraros C, Fernandez-Gutierrez A, Segura-Carretero A.

BMC Cancer. 2008 Dec 18;8:377.PMID: 19094209 [PubMed - indexed for MEDLINE]Related articlesFree article

Extra-virgin olive oil polyphenols inhibit HER2 (erbB-2)-induced malignant transformation in human breast epithelial cells: relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on the tyrosine kinase activity of HER2.

Menendez JA, Vazquez-Martin A, Oliveras-Ferraros C, Garcia-Villalba R, Carrasco-Pancorbo A, Fernandez-Gutierrez A, Segura-Carretero A.

Int J Oncol. 2009 Jan;34(1):43-51.PMID: 19082476 [PubMed - indexed for MEDLINE]Related articles

Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays.

Menendez JA, Vazquez-Martin A, Oliveras-Ferraros C, Garcia-Villalba R, Carrasco-Pancorbo A, Fernandez-Gutierrez A, Segura-Carretero A.

Int J Mol Med. 2008 Oct;22(4):433-9.PMID: 18813848 [PubMed - indexed for MEDLINE]Related articles

Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells.

Menendez JA, Vazquez-Martin A, Colomer R, Brunet J, Carrasco-Pancorbo A, Garcia-Villalba R, Fernandez-Gutierrez A, Segura-Carretero A.

BMC Cancer. 2007 May 9;7:80.PMID: 17490486 [PubMed - indexed for MEDLINE]Related articlesFree article

Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene.

Menendez JA, Vellon L, Lupu R.

Ann Oncol. 2005 Aug;16(8):1253-67. Epub 2005 May 3.PMID: 15870086 [PubMed - indexed for MEDLINE]Related articlesFree article

Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway.

Way TD, Kao MC, Lin JK.

J Biol Chem. 2004 Feb 6;279(6):4479-89. Epub 2003 Nov 5.PMID: 14602723 [PubMed - indexed for MEDLINE]Related articlesFree article

Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9).

Menendez JA, Lupu R.

Curr Pharm Biotechnol. 2006 Dec;7(6):495-502. Review.PMID: 17168666 [PubMed - indexed for MEDLINE]Related articles

HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail".

Menéndez JA, Vázquez-Martín A, Ropero S, Colomer R, Lupu R.

Clin Transl Oncol. 2006 Nov;8(11):812-20.PMID: 17134970 [PubMed - indexed for MEDLINE]Related articles

Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines.

Fini L, Hotchkiss E, Fogliano V, Graziani G, Romano M, De Vol EB, Qin H, Selgrad M, Boland CR, Ricciardiello L.

Carcinogenesis. 2008 Jan;29(1):139-46. Epub 2007 Nov 13.PMID: 17999988 [PubMed - indexed for MEDLINE]Related articlesFree article

Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification.

Menendez JA, Vellon L, Colomer R, Lupu R.

Ann Oncol. 2005 Mar;16(3):359-71. Epub 2005 Jan 10.PMID: 15642702 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth and molecular interactions of the anti-EGFR antibody cetuximab and the DNA cross-linking agent cisplatin in gefitinib-resistant MDA-MB-468 cells: new prospects in the treatment of triple-negative/basal-like breast cancer.

Oliveras-Ferraros C, Vazquez-Martin A, López-Bonet E, Martín-Castillo B, Del Barco S, Brunet J, Menendez JA.

Int J Oncol. 2008 Dec;33(6):1165-76.PMID: 19020749 [PubMed - indexed for MEDLINE]Related articles

Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain.

Gril B, Palmieri D, Bronder JL, Herring JM, Vega-Valle E, Feigenbaum L, Liewehr DJ, Steinberg SM, Merino MJ, Rubin SD, Steeg PS.

J Natl Cancer Inst. 2008 Aug 6;100(15):1092-103. Epub 2008 Jul 29.PMID: 18664652 [PubMed - indexed for MEDLINE]Related articlesFree article

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells.

Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA.

Cell Cycle. 2009 Jan 1;8(1):88-96. Epub 2009 Jan 1.PMID: 19106626 [PubMed - indexed for MEDLINE]Related articlesFree article

Mediterranean diet, olive oil and cancer.

Colomer R, Menéndez JA.

Clin Transl Oncol. 2006 Jan;8(1):15-21. Review.PMID: 16632435 [PubMed - indexed for MEDLINE]Related articles

Identification of lignans as major components in the phenolic fraction of olive oil.

Owen RW, Mier W, Giacosa A, Hull WE, Spiegelhalder B, Bartsch H.

Clin Chem. 2000 Jul;46(7):976-88.PMID: 10894841 [PubMed - indexed for MEDLINE]Related articlesFree article

Qualitative and semiquantitative analysis of phenolic compounds in extra virgin olive oils as a function of the ripening degree of olive fruits by different analytical techniques.

Bonoli M, Bendini A, Cerretani L, Lercker G, Toschi TG.

J Agric Food Chem. 2004 Nov 17;52(23):7026-32.PMID: 15537313 [PubMed - indexed for MEDLINE]Related articles

Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells.

Vazquez-Martin A, Colomer R, Brunet J, Lupu R, Menendez JA.

Cell Prolif. 2008 Feb;41(1):59-85.PMID: 18211286 [PubMed - indexed for MEDLINE]Related articles

Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells.

Vazquez-Martin A, Colomer R, Brunet J, Menendez JA.

Int J Oncol. 2007 Oct;31(4):769-76.PMID: 17786307 [PubMed - indexed for MEDLINE]Related articles

Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo.

Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF, Arteaga CL.

Cancer Res. 2001 Dec 15;61(24):8887-95.PMID: 11751413 [PubMed - indexed for MEDLINE]Related articlesFree article

Olive-oil consumption and health: the possible role of antioxidants.

Owen RW, Giacosa A, Hull WE, Haubner R, Würtele G, Spiegelhalder B, Bartsch H.

Lancet Oncol. 2000 Oct;1:107-12. Review.PMID: 11905662 [PubMed - indexed for MEDLINE]Related articles