PubMed

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.

Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK.

Diabetes. 2009 Mar;58(3):590-9. Epub 2008 Dec 15.PMID: 19074988 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG.

Mol Cell Biol. 2007 Nov;27(21):7727-34. Epub 2007 Aug 27.PMID: 17724080 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.

Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG.

J Biol Chem. 2005 Apr 15;280(15):15038-46. Epub 2005 Feb 7.PMID: 15699041 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression.

Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ.

Mol Endocrinol. 2004 Jun;18(6):1333-45. Epub 2004 Feb 19.PMID: 14976221 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH.

Diabetes. 2009 Jan;58(1):116-24. Epub 2008 Oct 24.PMID: 18952837 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.

Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM.

Diabetes. 2003 Jan;52(1):21-8.PMID: 12502489 [PubMed - indexed for MEDLINE]Related articlesFree article

FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver.

Huang X, Yang C, Luo Y, Jin C, Wang F, McKeehan WL.

Diabetes. 2007 Oct;56(10):2501-10. Epub 2007 Jul 30.PMID: 17664243 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in adiponectin and inflammatory genes in response to hormonal imbalances in female mice and exacerbation of depot selective visceral adiposity by high-fat diet: implications for insulin resistance.

Zhang H, Chen X, Aravindakshan J, Sairam MR.

Endocrinology. 2007 Dec;148(12):5667-79. Epub 2007 Aug 23.PMID: 17717050 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism.

Mao XQ, Yu F, Wang N, Wu Y, Zou F, Wu K, Liu M, Ouyang JP.

Phytomedicine. 2009 May;16(5):416-25. Epub 2009 Feb 6.PMID: 19201177 [PubMed - indexed for MEDLINE]Related articles

Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.

Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR.

Diabetes. 2008 Jan;57(1):77-85. Epub 2007 Oct 10.PMID: 17928396 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance.

Wilkes JJ, Lloyd DJ, Gekakis N.

Diabetes. 2009 May;58(5):1133-43. Epub 2009 Feb 10.PMID: 19208906 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF.

Diabetes. 2002 Aug;51(8):2405-11.PMID: 12145151 [PubMed - indexed for MEDLINE]Related articlesFree article

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11357-62. Epub 2002 Aug 8.PMID: 12169659 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression.

Yu XX, Pandey SK, Booten SL, Murray SF, Monia BP, Bhanot S.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E530-9. Epub 2008 Jan 15.PMID: 18198353 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.

Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, Vonderfecht S, Hecht R, Li YS, Lindberg RA, Chen JL, Jung DY, Zhang Z, Ko HJ, Kim JK, Véniant MM.

Diabetes. 2009 Jan;58(1):250-9. Epub 2008 Oct 7.PMID: 18840786 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.

Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB.

Mol Cell Biol. 2000 Aug;20(15):5479-89.PMID: 10891488 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.

Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF.

Diabetes. 2004 Jan;53(1):61-6.PMID: 14693698 [PubMed - indexed for MEDLINE]Related articlesFree article

CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis.

Rahman SM, Schroeder-Gloeckler JM, Janssen RC, Jiang H, Qadri I, Maclean KN, Friedman JE.

Hepatology. 2007 May;45(5):1108-17.PMID: 17464987 [PubMed - indexed for MEDLINE]Related articles

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC.

PLoS One. 2009;4(3):e4937. Epub 2009 Mar 19.PMID: 19295913 [PubMed - indexed for MEDLINE]Related articlesFree article