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    Results: 1 to 20 of 119

    1.

    m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction.

    Lindroos MM, Majamaa K, Tura A, Mari A, Kalliokoski KK, Taittonen MT, Iozzo P, Nuutila P.

    Diabetes. 2009 Mar;58(3):543-9. Epub 2008 Dec 10.PMID: 19073775 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes.

    Thamer C, Stumvoll M, Niess A, Tschritter O, Haap M, Becker R, Shirkavand F, Bachmann O, Rett K, Volk A, Häring H, Fritsche A.

    Diabetes Care. 2003 Jul;26(7):2126-32.PMID: 12832324 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test.

    Festa A, Williams K, Hanley AJ, Haffner SM.

    Diabetes. 2008 Jun;57(6):1638-44. Epub 2008 Mar 10.PMID: 18332099 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    High prevalence of impaired glucose homeostasis and myopathy in asymptomatic and oligosymptomatic 3243A>G mitochondrial DNA mutation-positive subjects.

    Frederiksen AL, Jeppesen TD, Vissing J, Schwartz M, Kyvik KO, Schmitz O, Poulsen PL, Andersen PH.

    J Clin Endocrinol Metab. 2009 Aug;94(8):2872-9. Epub 2009 May 26.PMID: 19470628 [PubMed - indexed for MEDLINE]Related articles

    5.

    Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.

    Nuutila P, Peltoniemi P, Oikonen V, Larmola K, Kemppainen J, Takala T, Sipilä H, Oksanen A, Ruotsalainen U, Bolli GB, Yki-Järvinen H.

    Diabetes. 2000 Jul;49(7):1084-91.PMID: 10909962 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography.

    Raitakari M, Nuutila P, Ruotsalainen U, Laine H, Teräs M, Iida H, Mäkimattila S, Utriainen T, Oikonen V, Sipilä H, Haaparanta M, Solin O, Wegelius U, Knuuti J, Yki-Järvinen H.

    Diabetes. 1996 Nov;45(11):1471-7.PMID: 8866549 [PubMed - indexed for MEDLINE]Related articles

    7.

    Assessment of beta-cell function during the oral glucose tolerance test by a minimal model of insulin secretion.

    Cretti A, Lehtovirta M, Bonora E, Brunato B, Zenti MG, Tosi F, Caputo M, Caruso B, Groop LC, Muggeo M, Bonadonna RC.

    Eur J Clin Invest. 2001 May;31(5):405-16.PMID: 11380592 [PubMed - indexed for MEDLINE]Related articles

    8.

    Muscle phenotype and mutation load in 51 persons with the 3243A>G mitochondrial DNA mutation.

    Jeppesen TD, Schwartz M, Frederiksen AL, Wibrand F, Olsen DB, Vissing J.

    Arch Neurol. 2006 Dec;63(12):1701-6.PMID: 17172609 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    In vivo effects of insulin on tumor and skeletal muscle glucose metabolism in patients with lymphoma.

    Minn H, Nuutila P, Lindholm P, Ruotsalainen U, Bergman J, Teräs M, Knuuti MJ.

    Cancer. 1994 Mar 1;73(5):1490-8.PMID: 8111717 [PubMed - indexed for MEDLINE]Related articles

    10.

    Diabetes mellitus associated with the 3243 mitochondrial tRNA(Leu)(UUR) mutation: insulin secretion and sensitivity.

    Suzuki Y, Iizuka T, Kobayashi T, Nishikawa T, Atsumi Y, Kadowaki T, Oka Y, Kadowaki H, Taniyama M, Hosokawa K, Asahina T, Matsuoka K.

    Metabolism. 1997 Sep;46(9):1019-23.PMID: 9284890 [PubMed - indexed for MEDLINE]Related articles

    11.

    Prevalence and progression of diabetes in mitochondrial disease.

    Whittaker RG, Schaefer AM, McFarland R, Taylor RW, Walker M, Turnbull DM.

    Diabetologia. 2007 Oct;50(10):2085-9. Epub 2007 Jul 26.PMID: 17653689 [PubMed - indexed for MEDLINE]Related articles

    12.

    Diminished insulin secretory response to glucose but normal insulin and glucagon secretory responses to arginine in a family with maternally inherited diabetes and deafness caused by mitochondrial tRNA(LEU(UUR)) gene mutation.

    Brändle M, Lehmann R, Maly FE, Schmid C, Spinas GA.

    Diabetes Care. 2001 Jul;24(7):1253-8.PMID: 11423511 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Increments in insulin sensitivity during intensive treatment are closely correlated with decrements in glucocorticoid receptor mRNA in skeletal muscle from patients with Type II diabetes.

    Vestergaard H, Bratholm P, Christensen NJ.

    Clin Sci (Lond). 2001 Nov;101(5):533-40.PMID: 11672459 [PubMed - indexed for MEDLINE]Related articles

    14.

    Beta- and alpha-cell dysfunction in subjects developing impaired glucose tolerance: outcome of a 12-year prospective study in postmenopausal Caucasian women.

    Ahrén B.

    Diabetes. 2009 Mar;58(3):726-31. Epub 2008 Dec 18.PMID: 19095762 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation.

    Velho G, Byrne MM, Clément K, Sturis J, Pueyo ME, Blanché H, Vionnet N, Fiet J, Passa P, Robert JJ, Polonsky KS, Froguel P.

    Diabetes. 1996 Apr;45(4):478-87.PMID: 8603770 [PubMed - indexed for MEDLINE]Related articles

    16.

    Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.

    Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium.

    Diabetes. 2007 Dec;56(12):3101-4. Epub 2007 Sep 5.PMID: 17804762 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes.

    Nuutila P, Knuuti J, Ruotsalainen U, Koivisto VA, Eronen E, Teräs M, Bergman J, Haaparanta M, Voipio-Pulkki LM, Viikari J, et al.

    Am J Physiol. 1993 May;264(5 Pt 1):E756-62.PMID: 8498497 [PubMed - indexed for MEDLINE]Related articles

    18.

    Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes.

    Hällsten K, Virtanen KA, Lönnqvist F, Sipilä H, Oksanen A, Viljanen T, Rönnemaa T, Viikari J, Knuuti J, Nuutila P.

    Diabetes. 2002 Dec;51(12):3479-85.PMID: 12453903 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Interactions of impaired glucose transport and phosphorylation in skeletal muscle insulin resistance: a dose-response assessment using positron emission tomography.

    Williams KV, Price JC, Kelley DE.

    Diabetes. 2001 Sep;50(9):2069-79.PMID: 11522673 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Acute effects of celiprolol on muscle blood flow and insulin sensitivity: studies using [15O]-water, [18F]-fluorodeoxyglucose and positron emission tomography.

    Malminiemi K, Laine H, Knuuti MJ, Ruotsalainen U, Oikonen V, Haaparanta M, Nuutila P.

    Eur J Clin Pharmacol. 1997;52(1):19-26.PMID: 9143862 [PubMed - indexed for MEDLINE]Related articles

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