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    Results: 1 to 20 of 116

    1.

    Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets.

    Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML.

    Diabetes. 2009 Mar;58(3):663-72. Epub 2008 Dec 10.PMID: 19073772 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets.

    Kwon G, Marshall CA, Liu H, Pappan KL, Remedi MS, McDaniel ML.

    J Biol Chem. 2006 Feb 10;281(6):3261-7. Epub 2005 Dec 12.PMID: 16344552 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets.

    Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML.

    Diabetes. 2004 Dec;53 Suppl 3:S225-32. Review.PMID: 15561916 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes.

    Marzo N, Mora C, Fabregat ME, Martín J, Usac EF, Franco C, Barbacid M, Gomis R.

    Diabetologia. 2004 Apr;47(4):686-94.PMID: 15298346 [PubMed - indexed for MEDLINE]Related articles

    5.

    mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes.

    Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N, Leibowitz G.

    Diabetes. 2008 Apr;57(4):945-57. Epub 2008 Jan 3.PMID: 18174523 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells.

    McDaniel ML, Marshall CA, Pappan KL, Kwon G.

    Diabetes. 2002 Oct;51(10):2877-85. Review.PMID: 12351422 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation.

    Fornoni A, Pileggi A, Molano RD, Sanabria NY, Tejada T, Gonzalez-Quintana J, Ichii H, Inverardi L, Ricordi C, Pastori RL.

    Diabetologia. 2008 Feb;51(2):298-308. Epub 2007 Dec 8.PMID: 18066521 [PubMed - indexed for MEDLINE]Related articles

    8.

    A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.

    Buller CL, Loberg RD, Fan MH, Zhu Q, Park JL, Vesely E, Inoki K, Guan KL, Brosius FC 3rd.

    Am J Physiol Cell Physiol. 2008 Sep;295(3):C836-43. Epub 2008 Jul 23.PMID: 18650261 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Increased IRS-2 content and activation of IGF-I pathway contribute to enhance beta-cell mass in fetuses from undernourished pregnant rats.

    Fernández E, Martín MA, Fajardo S, Escrivá F, Alvarez C.

    Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E187-95. Epub 2006 Aug 15.PMID: 16912057 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection.

    Chong ZZ, Li F, Maiese K.

    Int J Mol Med. 2007 Feb;19(2):263-72.PMID: 17203200 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau.

    Meske V, Albert F, Ohm TG.

    J Biol Chem. 2008 Jan 4;283(1):100-9. Epub 2007 Oct 30.PMID: 17971449 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Endogenous IGF-I protects human intestinal smooth muscle cells from apoptosis by regulation of GSK-3 beta activity.

    Kuemmerle JF.

    Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G101-10. Epub 2004 Aug 5.PMID: 15297258 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

    Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG Jr, Rhodes CJ.

    J Biol Chem. 2001 Jun 15;276(24):21110-20. Epub 2001 Mar 27.PMID: 11274216 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.

    Pham PT, Heydrick SJ, Fox HL, Kimball SR, Jefferson LS Jr, Lynch CJ.

    J Cell Biochem. 2000 Sep 7;79(3):427-41.PMID: 10972980 [PubMed - indexed for MEDLINE]Related articles

    15.

    Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats.

    Henriksen EJ, Teachey MK.

    Metabolism. 2007 Jul;56(7):931-8.PMID: 17570255 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5).

    Friedrichsen BN, Galsgaard ED, Nielsen JH, Møldrup A.

    Mol Endocrinol. 2001 Jan;15(1):136-48.PMID: 11145745 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells.

    Li Y, Wang Z, Kong D, Murthy S, Dou QP, Sheng S, Reddy GP, Sarkar FH.

    J Biol Chem. 2007 Jul 20;282(29):21542-50. Epub 2007 May 23.PMID: 17522055 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats.

    Sanders JA, Lakhani A, Phornphutkul C, Wu KY, Gruppuso PA.

    Am J Physiol Cell Physiol. 2008 Aug;295(2):C406-13. Epub 2008 Jun 11.PMID: 18550700 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    A role for Akt in epidermal growth factor-stimulated cell cycle progression in cultured hepatocytes: generation of a hyperproliferative window after adenoviral expression of constitutively active Akt.

    Luo Y, Dixon CJ, Hall JF, White PJ, Boarder MR.

    J Pharmacol Exp Ther. 2007 Jun;321(3):884-91. Epub 2007 Mar 19.PMID: 17371807 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Inhibition of glycogen synthase kinase-3.

    Ougolkov AV, Billadeau DD.

    Methods Mol Biol. 2008;468:67-75.PMID: 19099246 [PubMed - indexed for MEDLINE]Related articles

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