PubMed

Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.

Tam CH, Ma RC, So WY, Wang Y, Lam VK, Germer S, Martin M, Chan JC, Ng MC.

Diabetes. 2009 Mar;58(3):765-9. Epub 2008 Dec 10.PMID: 19073768 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.

Qi Q, Wu Y, Li H, Loos RJ, Hu FB, Sun L, Lu L, Pan A, Liu C, Wu H, Chen L, Yu Z, Lin X.

Diabetologia. 2009 May;52(5):834-43. Epub 2009 Feb 25.PMID: 19241058 [PubMed - indexed for MEDLINE]Related articles

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

Vaxillaire M, Cavalcanti-Proença C, Dechaume A, Tichet J, Marre M, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2008 Aug;57(8):2253-7. Epub 2008 Jun 12.PMID: 18556336 [PubMed - indexed for MEDLINE]Related articlesFree article

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.

Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O.

Diabetologia. 2008 Jan;51(1):70-5. Epub 2007 Nov 16. Erratum in: Diabetologia. 2008 Feb;51(2):383. PMID: 18008060 [PubMed - indexed for MEDLINE]Related articles

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.

Orho-Melander M, Melander O, Guiducci C, Perez-Martinez P, Corella D, Roos C, Tewhey R, Rieder MJ, Hall J, Abecasis G, Tai ES, Welch C, Arnett DK, Lyssenko V, Lindholm E, Saxena R, de Bakker PI, Burtt N, Voight BF, Hirschhorn JN, Tucker KL, Hedner T, Tuomi T, Isomaa B, Eriksson KF, Taskinen MR, Wahlstrand B, Hughes TE, Parnell LD, Lai CQ, Berglund G, Peltonen L, Vartiainen E, Jousilahti P, Havulinna AS, Salomaa V, Nilsson P, Groop L, Altshuler D, Ordovas JM, Kathiresan S.

Diabetes. 2008 Nov;57(11):3112-21. Epub 2008 Aug 4.PMID: 18678614 [PubMed - indexed for MEDLINE]Related articlesFree article

The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.

Webster RJ, Warrington NM, Weedon MN, Hattersley AT, McCaskie PA, Beilby JP, Palmer LJ, Frayling TM.

Diabetologia. 2009 Jan;52(1):106-14. Epub 2008 Nov 19.PMID: 19018513 [PubMed - indexed for MEDLINE]Related articles

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.

Perez-Martinez P, Corella D, Shen J, Arnett DK, Yiannakouris N, Tai ES, Orho-Melander M, Tucker KL, Tsai M, Straka RJ, Province M, Kai CS, Perez-Jimenez F, Lai CQ, Lopez-Miranda J, Guillen M, Parnell LD, Borecki I, Kathiresan S, Ordovas JM.

Am J Clin Nutr. 2009 Jan;89(1):391-9. Epub 2008 Dec 3.PMID: 19056598 [PubMed - indexed for MEDLINE]Related articles

Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity.

García-Herrero CM, Galán M, Vincent O, Flández B, Gargallo M, Delgado-Alvarez E, Blázquez E, Navas MA.

Diabetologia. 2007 Feb;50(2):325-33. Epub 2006 Dec 21.PMID: 17186219 [PubMed - indexed for MEDLINE]Related articles

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.

Reiling E, van 't Riet E, Groenewoud MJ, Welschen LM, van Hove EC, Nijpels G, Maassen JA, Dekker JM, 't Hart LM.

Diabetologia. 2009 Sep;52(9):1866-70. Epub 2009 Jun 17.PMID: 19533084 [PubMed - in process]Related articlesFree article

Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.

Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L, Wilkin TJ, McCarthy A, Ben-Shlomo Y, Davey Smith G, Ring S, Jones R, Golding J, Byberg L, Mann V, Axelsson T, Syvänen AC, Leon D, Hattersley AT.

Diabetes. 2005 Feb;54(2):576-81.PMID: 15677518 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.

Holmkvist J, Almgren P, Lyssenko V, Lindgren CM, Eriksson KF, Isomaa B, Tuomi T, Nilsson P, Groop L.

Diabetes. 2008 Jun;57(6):1738-44. Epub 2008 Mar 10.PMID: 18332101 [PubMed - indexed for MEDLINE]Related articlesFree article

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, Voss LD, Jeffery AN, Metcalf B, Ferrucci L, Corsi AM, Murray A, Melzer D, Knight B, Shields B, Smith GD, Hattersley AT, Di Rienzo A, Frayling TM.

Am J Hum Genet. 2006 Dec;79(6):991-1001. Epub 2006 Oct 6.PMID: 17186458 [PubMed - indexed for MEDLINE]Related articlesFree article

'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.

Müller TD, Hinney A, Scherag A, Nguyen TT, Schreiner F, Schäfer H, Hebebrand J, Roth CL, Reinehr T.

BMC Med Genet. 2008 Sep 17;9:85.PMID: 18799002 [PubMed - indexed for MEDLINE]Related articlesFree article

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.

Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC.

Diabetes. 2008 Jul;57(7):1971-7. Epub 2008 Apr 21.PMID: 18426862 [PubMed - indexed for MEDLINE]Related articlesFree article

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.

Beer NL, Tribble ND, McCulloch LJ, Roos C, Johnson PR, Orho-Melander M, Gloyn AL.

Hum Mol Genet. 2009 Nov 1;18(21):4081-8. Epub 2009 Jul 30.PMID: 19643913 [PubMed - in process]Related articlesFree article

Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study.

Hivert MF, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC.

Diabetes. 2009 Mar;58(3):750-6. Epub 2008 Dec 15.PMID: 19074981 [PubMed - indexed for MEDLINE]Related articlesFree article

Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.

Chambers JC, Zhang W, Zabaneh D, Sehmi J, Jain P, McCarthy MI, Froguel P, Ruokonen A, Balding D, Jarvelin MR, Scott J, Elliott P, Kooner JS.

Diabetes. 2009 Nov;58(11):2703-8. Epub 2009 Aug 3.PMID: 19651812 [PubMed - in process]Related articles

A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.

Rose CS, Ek J, Urhammer SA, Glümer C, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T.

Diabetes. 2005 Oct;54(10):3026-31.PMID: 16186409 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study.

Shen H, Pollin TI, Damcott CM, McLenithan JC, Mitchell BD, Shuldiner AR.

Hum Genet. 2009 Oct;126(4):567-74. Epub 2009 Jun 13.PMID: 19526250 [PubMed - indexed for MEDLINE]Related articles

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.

Vaxillaire M, Veslot J, Dina C, Proença C, Cauchi S, Charpentier G, Tichet J, Fumeron F, Marre M, Meyre D, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2008 Jan;57(1):244-54. Epub 2007 Oct 31.PMID: 17977958 [PubMed - indexed for MEDLINE]Related articlesFree article