PubMed

Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice.

De Silva FS, Moss B.

Virol J. 2008 Dec 2;5:145.PMID: 19055736 [PubMed - indexed for MEDLINE]Related articlesFree article

Vaccinia virus uracil DNA glycosylase has an essential role in DNA synthesis that is independent of its glycosylase activity: catalytic site mutations reduce virulence but not virus replication in cultured cells.

De Silva FS, Moss B.

J Virol. 2003 Jan;77(1):159-66.PMID: 12477821 [PubMed - indexed for MEDLINE]Related articlesFree article

Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.

Prichard MN, Kern ER, Quenelle DC, Keith KA, Moyer RW, Turner PC.

Virol J. 2008 Mar 5;5:39.PMID: 18321387 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of uracil-DNA glycosylase and dUTPase in virus replication.

Chen R, Wang H, Mansky LM.

J Gen Virol. 2002 Oct;83(Pt 10):2339-45. Review.PMID: 12237414 [PubMed - indexed for MEDLINE]Related articlesFree article

The simian varicella virus uracil DNA glycosylase and dUTPase genes are expressed in vivo, but are non-essential for replication in cell culture.

Ward TM, Williams MV, Traina-Dorge V, Gray WL.

Virus Res. 2009 Jun;142(1-2):78-84. Epub 2009 Feb 4.PMID: 19200445 [PubMed - indexed for MEDLINE]Related articles

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.

Andersen S, Heine T, Sneve R, König I, Krokan HE, Epe B, Nilsen H.

Carcinogenesis. 2005 Mar;26(3):547-55. Epub 2004 Nov 25.PMID: 15564287 [PubMed - indexed for MEDLINE]Related articlesFree article

Incorporation of uracil into viral DNA correlates with reduced replication of EIAV in macrophages.

Steagall WK, Robek MD, Perry ST, Fuller FJ, Payne SL.

Virology. 1995 Jul 10;210(2):302-13.PMID: 7542416 [PubMed - indexed for MEDLINE]Related articles

Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.

Pyles RB, Thompson RL.

J Virol. 1994 Jul;68(7):4514-24.PMID: 8207826 [PubMed - indexed for MEDLINE]Related articlesFree article

Human cytomegalovirus uracil DNA glycosylase is required for the normal temporal regulation of both DNA synthesis and viral replication.

Prichard MN, Duke GM, Mocarski ES.

J Virol. 1996 May;70(5):3018-25.PMID: 8627778 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of a uracil DNA glycosylase (UNG) inhibitor in mammalian cells: varicella-zoster virus can replicate in vitro in the absence of detectable UNG activity.

Reddy SM, Williams M, Cohen JI.

Virology. 1998 Nov 25;251(2):393-401.PMID: 9837803 [PubMed - indexed for MEDLINE]Related articles

Requirement for uracil-DNA glycosylase during the transition to late-phase cytomegalovirus DNA replication.

Courcelle CT, Courcelle J, Prichard MN, Mocarski ES.

J Virol. 2001 Aug;75(16):7592-601.PMID: 11462031 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in active-site residues of the uracil-DNA glycosylase encoded by vaccinia virus are incompatible with virus viability.

Ellison KS, Peng W, McFadden G.

J Virol. 1996 Nov;70(11):7965-73.PMID: 8892920 [PubMed - indexed for MEDLINE]Related articlesFree article

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication.

Nilsen H, Rosewell I, Robins P, Skjelbred CF, Andersen S, Slupphaug G, Daly G, Krokan HE, Lindahl T, Barnes DE.

Mol Cell. 2000 Jun;5(6):1059-65.PMID: 10912000 [PubMed - indexed for MEDLINE]Related articles

Isolation and characterisation of herpes simplex virus type 1 mutants which fail to induce dUTPase activity.

Fisher FB, Preston VG.

Virology. 1986 Jan 15;148(1):190-7.PMID: 3002029 [PubMed - indexed for MEDLINE]Related articles

The role of retroviral dUTPases in replication and virulence.

Payne SL, Elder JH.

Curr Protein Pept Sci. 2001 Dec;2(4):381-8. Review.PMID: 12374097 [PubMed - indexed for MEDLINE]Related articles

Expanding the repertoire of Modified Vaccinia Ankara-based vaccine vectors via genetic complementation strategies.

Garber DA, O'Mara LA, Zhao J, Gangadhara S, An I, Feinberg MB.

PLoS One. 2009;4(5):e5445. Epub 2009 May 6.PMID: 19421328 [PubMed - indexed for MEDLINE]Related articlesFree article

Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity.

Lichtenstein DL, Rushlow KE, Cook RF, Raabe ML, Swardson CJ, Kociba GJ, Issel CJ, Montelaro RC.

J Virol. 1995 May;69(5):2881-8.PMID: 7707512 [PubMed - indexed for MEDLINE]Related articlesFree article

Uracils as a cellular weapon against viruses and mechanisms of viral escape.

Priet S, Sire J, Quérat G.

Curr HIV Res. 2006 Jan;4(1):31-42. Review.PMID: 16454709 [PubMed - indexed for MEDLINE]Related articles

Substrate specificity of homogeneous monkeypox virus uracil-DNA glycosylase.

Duraffour S, Ishchenko AA, Saparbaev M, Crance JM, Garin D.

Biochemistry. 2007 Oct 23;46(42):11874-81. Epub 2007 Oct 2.PMID: 17910420 [PubMed - indexed for MEDLINE]Related articles

Properties and functions of human uracil-DNA glycosylase from the UNG gene.

Krokan HE, Otterlei M, Nilsen H, Kavli B, Skorpen F, Andersen S, Skjelbred C, Akbari M, Aas PA, Slupphaug G.

Prog Nucleic Acid Res Mol Biol. 2001;68:365-86. Review.PMID: 11554311 [PubMed - indexed for MEDLINE]Related articles