PubMed

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1.

Zhuang Y, Miskimins WK.

J Mol Signal. 2008 Dec 1;3:18.PMID: 19046439 [PubMed - in process]Related articlesFree article

Metformin induces unique biological and molecular responses in triple negative breast cancer cells.

Liu B, Fan Z, Edgerton SM, Deng XS, Alimova IN, Lind SE, Thor AD.

Cell Cycle. 2009 Jul 1;8(13):2031-40. Epub 2009 Jul 21.PMID: 19440038 [PubMed - indexed for MEDLINE]Related articles

Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product.

Elangovan S, Hsieh TC, Wu JM.

Anticancer Res. 2008 Sep-Oct;28(5A):2641-7.PMID: 19035289 [PubMed - indexed for MEDLINE]Related articles

EGFR and Src are involved in indole-3-carbinol-induced death and cell cycle arrest of human breast cancer cells.

Moiseeva EP, Heukers R, Manson MM.

Carcinogenesis. 2007 Feb;28(2):435-45. Epub 2006 Sep 6.PMID: 16956907 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells.

Masamha CP, Benbrook DM.

Cancer Res. 2009 Aug 15;69(16):6565-72. Epub 2009 Jul 28.PMID: 19638577 [PubMed - indexed for MEDLINE]Related articles

Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity.

Duncan RE, Lau D, El-Sohemy A, Archer MC.

Biochem Pharmacol. 2004 Nov 1;68(9):1739-47. Erratum in: Biochem Pharmacol. 2005 Jan 15;69(2):361. PMID: 15450939 [PubMed - indexed for MEDLINE]Related articles

Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells.

Jiang H, Coleman J, Miskimins R, Miskimins WK.

Cancer Cell Int. 2003 Feb 18;3(1):2.PMID: 12633504 [PubMed - as supplied by publisher]Related articlesFree article

Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features.

Ioachim E.

Int J Clin Pract. 2008 Nov;62(11):1736-43.PMID: 19143860 [PubMed - indexed for MEDLINE]Related articles

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.

Phoenix KN, Vumbaca F, Claffey KP.

Breast Cancer Res Treat. 2009 Jan;113(1):101-11. Epub 2008 Feb 7.PMID: 18256928 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin attenuates ovarian cancer cell growth in an AMP- kinase dispensable manner.

Rattan R, Giri S, Hartmann L, Shridhar V.

J Cell Mol Med. 2009 Oct 29. [Epub ahead of print]PMID: 19874425 [PubMed - as supplied by publisher]Related articles

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F.

Oncogene. 2008 Jun 5;27(25):3576-86. Epub 2008 Jan 21.PMID: 18212742 [PubMed - indexed for MEDLINE]Related articles

A plant oxylipin, 12-oxo-phytodienoic acid, inhibits proliferation of human breast cancer cells by targeting cyclin D1.

Altiok N, Mezzadra H, Patel P, Koyuturk M, Altiok S.

Breast Cancer Res Treat. 2008 May;109(2):315-23. Epub 2007 Jul 19.PMID: 17638069 [PubMed - indexed for MEDLINE]Related articles

Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells.

Park EJ, Min HY, Chung HJ, Hong JY, Kang YJ, Hung TM, Youn UJ, Kim YS, Bae K, Kang SS, Lee SK.

Cancer Lett. 2009 May 18;277(2):133-40. Epub 2009 Jan 9.PMID: 19135778 [PubMed - indexed for MEDLINE]Related articles

Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells.

Lee SH, Cekanova M, Baek SJ.

Mol Carcinog. 2008 Mar;47(3):197-208.PMID: 18058799 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells.

Im JY, Park H, Kang KW, Choi WS, Kim HS.

Chem Biol Interact. 2008 Apr 15;172(3):235-44. Epub 2008 Feb 1.PMID: 18313654 [PubMed - indexed for MEDLINE]Related articles

"Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells".

Eto I.

Cancer Cell Int. 2006 Aug 9;6:20.PMID: 16899133 [PubMed]Related articlesFree article

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro.

Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, Lind SE, Thor AD.

Cell Cycle. 2009 Mar 15;8(6):909-15. Epub 2009 Mar 26.PMID: 19221498 [PubMed - indexed for MEDLINE]Related articles

Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins.

Koziczak M, Holbro T, Hynes NE.

Oncogene. 2004 Apr 29;23(20):3501-8.PMID: 15116089 [PubMed - indexed for MEDLINE]Related articles

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells.

Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA.

Cell Cycle. 2009 Jan 1;8(1):88-96. Epub 2009 Jan 1.PMID: 19106626 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D.

Zang Y, Yu LF, Nan FJ, Feng LY, Li J.

J Biol Chem. 2009 Mar 6;284(10):6175-84. Epub 2009 Jan 14.PMID: 19144636 [PubMed - indexed for MEDLINE]Related articlesFree article