PubMed

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.

Stratford AL, Fry CJ, Desilets C, Davies AH, Cho YY, Li Y, Dong Z, Berquin IM, Roux PP, Dunn SE.

Breast Cancer Res. 2008;10(6):R99. Epub 2008 Nov 27.PMID: 19036157 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.

Stratford AL, Habibi G, Astanehe A, Jiang H, Hu K, Park E, Shadeo A, Buys TP, Lam W, Pugh T, Marra M, Nielsen TO, Klinge U, Mertens PR, Aparicio S, Dunn SE.

Breast Cancer Res. 2007;9(5):R61.PMID: 17875215 [PubMed - indexed for MEDLINE]Related articlesFree article

The phosphoinositide-dependent kinase-1 inhibitor 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) prevents Y-box binding protein-1 from inducing epidermal growth factor receptor.

To K, Zhao Y, Jiang H, Hu K, Wang M, Wu J, Lee C, Yokom DW, Stratford AL, Klinge U, Mertens PR, Chen CS, Bally M, Yapp D, Dunn SE.

Mol Pharmacol. 2007 Sep;72(3):641-52. Epub 2007 Jun 26.PMID: 17595327 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1.

Astanehe A, Finkbeiner MR, Hojabrpour P, To K, Fotovati A, Shadeo A, Stratford AL, Lam WL, Berquin IM, Duronio V, Dunn SE.

Oncogene. 2009 Jun 25;28(25):2406-18. Epub 2009 May 11.PMID: 19430491 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.

Roux PP, Richards SA, Blenis J.

Mol Cell Biol. 2003 Jul;23(14):4796-804.PMID: 12832467 [PubMed - indexed for MEDLINE]Related articlesFree article

14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.

Cavet ME, Lehoux S, Berk BC.

J Biol Chem. 2003 May 16;278(20):18376-83. Epub 2003 Mar 4.PMID: 12618428 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.

Smith JA, Poteet-Smith CE, Xu Y, Errington TM, Hecht SM, Lannigan DA.

Cancer Res. 2005 Feb 1;65(3):1027-34.PMID: 15705904 [PubMed - indexed for MEDLINE]Related articlesFree article

The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation.

Clark DE, Errington TM, Smith JA, Frierson HF Jr, Weber MJ, Lannigan DA.

Cancer Res. 2005 Apr 15;65(8):3108-16.PMID: 15833840 [PubMed - indexed for MEDLINE]Related articlesFree article

Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation.

Schlange T, Matsuda Y, Lienhard S, Huber A, Hynes NE.

Breast Cancer Res. 2007;9(5):R63.PMID: 17897439 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.

Kang S, Dong S, Guo A, Ruan H, Lonial S, Khoury HJ, Gu TL, Chen J.

J Biol Chem. 2008 Feb 22;283(8):4652-7. Epub 2007 Dec 21.PMID: 18156174 [PubMed - indexed for MEDLINE]Related articlesFree article

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells.

Marty B, Maire V, Gravier E, Rigaill G, Vincent-Salomon A, Kappler M, Lebigot I, Djelti F, Tourdès A, Gestraud P, Hupé P, Barillot E, Cruzalegui F, Tucker GC, Stern MH, Thiery JP, Hickman JA, Dubois T.

Breast Cancer Res. 2008;10(6):R101. Epub 2008 Dec 3.PMID: 19055754 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.

Zhao Y, Bjorbaek C, Moller DE.

J Biol Chem. 1996 Nov 22;271(47):29773-9.PMID: 8939914 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of p90 ribosomal S6-kinase-1 in oltipraz-induced specific phosphorylation of CCAAT/enhancer binding protein-beta for GSTA2 gene transactivation.

Lee SJ, Kim SG.

Mol Pharmacol. 2006 Jan;69(1):385-96. Epub 2005 Oct 24.PMID: 16246908 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of protein kinase A activity by p90 ribosomal S6 kinase 1.

Gao X, Patel TB.

J Biol Chem. 2009 Nov 27;284(48):33070-8. Epub 2009 Oct 5.PMID: 19808666 [PubMed - indexed for MEDLINE]Related articles

Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.

Cho YY, Yao K, Kim HG, Kang BS, Zheng D, Bode AM, Dong Z.

Cancer Res. 2007 Sep 1;67(17):8104-12.PMID: 17804722 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2.

Wu J, Lee C, Yokom D, Jiang H, Cheang MC, Yorida E, Turbin D, Berquin IM, Mertens PR, Iftner T, Gilks CB, Dunn SE.

Cancer Res. 2006 May 1;66(9):4872-9.PMID: 16651443 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.

Silverman E, Frödin M, Gammeltoft S, Maller JL.

Mol Cell Biol. 2004 Dec;24(24):10573-83.PMID: 15572664 [PubMed - indexed for MEDLINE]Related articlesFree article

Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells.

Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, Dunn SE.

Oncogene. 2009 Mar 19;28(11):1421-31. Epub 2009 Jan 19.PMID: 19151767 [PubMed - indexed for MEDLINE]Related articles

The RSK factors of activating the Ras/MAPK signaling cascade.

Carriere A, Ray H, Blenis J, Roux PP.

Front Biosci. 2008 May 1;13:4258-75. Review.PMID: 18508509 [PubMed - indexed for MEDLINE]Related articles

Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells.

Berquin IM, Pang B, Dziubinski ML, Scott LM, Chen YQ, Nolan GP, Ethier SP.

Oncogene. 2005 Apr 28;24(19):3177-86.PMID: 15735691 [PubMed - indexed for MEDLINE]Related articles