PubMed

A role for von Hippel-Lindau protein in pancreatic beta-cell function.

Puri S, Cano DA, Hebrok M.

Diabetes. 2009 Feb;58(2):433-41. Epub 2008 Nov 25.PMID: 19033400 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ.

J Clin Invest. 2009 Jan;119(1):125-35. doi: 10.1172/JCI26934. Epub 2008 Dec 8.PMID: 19065050 [PubMed - indexed for MEDLINE]Related articlesFree article

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.

Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W.

Genes Dev. 2008 Nov 15;22(22):3135-46.PMID: 19056893 [PubMed - indexed for MEDLINE]Related articlesFree article

Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.

Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK.

PLoS One. 2009;4(4):e4897. Epub 2009 Apr 2.PMID: 19340311 [PubMed - indexed for MEDLINE]Related articlesFree article

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.

Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH.

Oncogene. 2000 Nov 16;19(48):5435-43.PMID: 11114720 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.

Zatyka M, da Silva NF, Clifford SC, Morris MR, Wiesener MS, Eckardt KU, Houlston RS, Richards FM, Latif F, Maher ER.

Cancer Res. 2002 Jul 1;62(13):3803-11.PMID: 12097293 [PubMed - indexed for MEDLINE]Related articlesFree article

Von Hippel-Lindau disease and endocrine tumour susceptibility.

Woodward ER, Maher ER.

Endocr Relat Cancer. 2006 Jun;13(2):415-25. Review.PMID: 16728571 [PubMed - indexed for MEDLINE]Related articlesFree article

A variety of phenotype with R161Q germline mutation of the von Hippel-Lindau tumor suppressor gene in Japanese kindred.

Iida K, Okimura Y, Takahashi K, Inomata S, Iguchi G, Kaji H, Chihara K.

Int J Mol Med. 2004 Mar;13(3):401-4.PMID: 14767570 [PubMed - indexed for MEDLINE]Related articles

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

Haase VH, Glickman JN, Socolovsky M, Jaenisch R.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1583-8.PMID: 11171994 [PubMed - indexed for MEDLINE]Related articlesFree article

The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells.

Peruzzi B, Athauda G, Bottaro DP.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14531-6. Epub 2006 Sep 18.PMID: 16983094 [PubMed - indexed for MEDLINE]Related articlesFree article

Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells.

Gorospe M, Egan JM, Zbar B, Lerman M, Geil L, Kuzmin I, Holbrook NJ.

Mol Cell Biol. 1999 Feb;19(2):1289-300.PMID: 9891063 [PubMed - indexed for MEDLINE]Related articlesFree article

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WG Jr.

Hum Mol Genet. 2001 May 1;10(10):1019-27.PMID: 11331612 [PubMed - indexed for MEDLINE]Related articlesFree article

von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase.

Park SK, Haase VH, Johnson RS.

Int J Oncol. 2007 Feb;30(2):341-8.PMID: 17203215 [PubMed - indexed for MEDLINE]Related articles

Germline mutation of von Hippel-Lindau (VHL) gene 695 G>A (R161Q) in a patient with a peculiar phenotype with type 2C VHL syndrome.

Santarpia L, Lapa D, Benvenga S.

Ann N Y Acad Sci. 2006 Aug;1073:198-202.PMID: 17102087 [PubMed - indexed for MEDLINE]Related articles

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor.

Rankin EB, Tomaszewski JE, Haase VH.

Cancer Res. 2006 Mar 1;66(5):2576-83.PMID: 16510575 [PubMed - indexed for MEDLINE]Related articlesFree article

Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas.

Na X, Wu G, Ryan CK, Schoen SR, di'Santagnese PA, Messing EM.

J Urol. 2003 Aug;170(2 Pt 1):588-92.PMID: 12853836 [PubMed - indexed for MEDLINE]Related articles

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.

Ma W, Tessarollo L, Hong SB, Baba M, Southon E, Back TC, Spence S, Lobe CG, Sharma N, Maher GW, Pack S, Vortmeyer AO, Guo C, Zbar B, Schmidt LS.

Cancer Res. 2003 Sep 1;63(17):5320-8.PMID: 14500363 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic study of a large Chinese kindred with von Hippel-Lindau disease.

Huang YR, Zhang J, Wang JD, Fan XD.

Chin Med J (Engl). 2004 Apr;117(4):552-7.PMID: 15109448 [PubMed - indexed for MEDLINE]Related articlesFree article

Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor.

Lolkema MP, Mans DA, Ulfman LH, Volpi S, Voest EE, Giles RH.

Eur J Hum Genet. 2008 Jan;16(1):73-8. Epub 2007 Oct 3.PMID: 17912253 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein.

Lee S, Neumann M, Stearman R, Stauber R, Pause A, Pavlakis GN, Klausner RD.

Mol Cell Biol. 1999 Feb;19(2):1486-97.PMID: 9891082 [PubMed - indexed for MEDLINE]Related articlesFree article