PubMed

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations.

Maarouf CL, Daugs ID, Spina S, Vidal R, Kokjohn TA, Patton RL, Kalback WM, Luehrs DC, Walker DG, Castaño EM, Beach TG, Ghetti B, Roher AE.

Mol Neurodegener. 2008 Nov 20;3:20.PMID: 19021905 [PubMed - in process]Related articlesFree article

Pathological and physiological functions of presenilins.

Vetrivel KS, Zhang YW, Xu H, Thinakaran G.

Mol Neurodegener. 2006 Jun 12;1:4.PMID: 16930451 [PubMed]Related articlesFree article

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

Kumar-Singh S, Theuns J, Van Broeck B, Pirici D, Vennekens K, Corsmit E, Cruts M, Dermaut B, Wang R, Van Broeckhoven C.

Hum Mutat. 2006 Jul;27(7):686-95.PMID: 16752394 [PubMed - indexed for MEDLINE]Related articles

Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secreted Amyloid-beta Protein Precursor Generated by beta-Secretase Cleavage.

Zhang C, Browne A, Kim DY, Tanzi RE.

Curr Alzheimer Res. 2009 Dec 1. [Epub ahead of print]PMID: 19715549 [PubMed - as supplied by publisher]Related articles

Variations in the neuropathology of familial Alzheimer's disease.

Shepherd C, McCann H, Halliday GM.

Acta Neuropathol. 2009 Jul;118(1):37-52. Epub 2009 Mar 22. Review.PMID: 19306098 [PubMed - indexed for MEDLINE]Related articles

Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population.

Albani D, Roiter I, Artuso V, Batelli S, Prato F, Pesaresi M, Galimberti D, Scarpini E, Bruni A, Franceschi M, Piras MR, Confaloni A, Forloni G.

Neurobiol Aging. 2007 Nov;28(11):1682-8. Epub 2006 Sep 6.PMID: 16952411 [PubMed - indexed for MEDLINE]Related articles

Mutant presenilin 1 increases the expression and activity of BACE1.

Giliberto L, Borghi R, Piccini A, Mangerini R, Sorbi S, Cirmena G, Garuti A, Ghetti B, Tagliavini F, Mughal MR, Mattson MP, Zhu X, Wang X, Guglielmotto M, Tamagno E, Tabaton M.

J Biol Chem. 2009 Apr 3;284(14):9027-38. Epub 2009 Feb 5.PMID: 19196715 [PubMed - indexed for MEDLINE]Related articles

Early-onset Alzheimer disease in an Italian family with presenilin-1 double mutation E318G and G394V.

Batelli S, Albani D, Prato F, Polito L, Franceschi M, Gavazzi A, Forloni G.

Alzheimer Dis Assoc Disord. 2008 Apr-Jun;22(2):184-7.PMID: 18525293 [PubMed - indexed for MEDLINE]Related articles

Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.

Placanica L, Zhu L, Li YM.

PLoS One. 2009;4(4):e5088. Epub 2009 Apr 7.PMID: 19352431 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.

Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.

J Neurochem. 2009 Jul;110(1):275-83. Epub 2009 Apr 29.PMID: 19457123 [PubMed - indexed for MEDLINE]Related articles

Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.

Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.

J Alzheimers Dis. 2009 Mar;16(3):565-75.PMID: 19276551 [PubMed - indexed for MEDLINE]Related articles

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

Futai E, Yagishita S, Ishiura S.

J Biol Chem. 2009 May 8;284(19):13013-22. Epub 2009 Mar 2.PMID: 19254953 [PubMed - indexed for MEDLINE]Related articlesFree article

Spatial correlations between beta-amyloid (Abeta) deposits and blood vessels in familial Alzheimer's disease.

Armstrong RA.

Folia Neuropathol. 2008;46(4):241-8.PMID: 19169965 [PubMed - indexed for MEDLINE]Related articlesFree article

Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.

Leverenz JB, Fishel MA, Peskind ER, Montine TJ, Nochlin D, Steinbart E, Raskind MA, Schellenberg GD, Bird TD, Tsuang D.

Arch Neurol. 2006 Mar;63(3):370-6.PMID: 16533963 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel T719P AbetaPP mutation unbalances the relative proportion of amyloid-beta peptides.

Ghidoni R, Albertini V, Squitti R, Paterlini A, Bruno A, Bernardini S, Cassetta E, Rossini PM, Squitieri F, Benussi L, Binetti G.

J Alzheimers Dis. 2009;18(2):295-303.PMID: 19584443 [PubMed - indexed for MEDLINE]Related articles

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villà-Freixa J, Suzuki T, Fernàndez-Busquets X, Valverde MA, de Strooper B, Muñoz FJ.

Brain. 2009 May;132(Pt 5):1335-45. Epub 2009 Feb 27.PMID: 19251756 [PubMed - indexed for MEDLINE]Related articles

Wnt signaling in Alzheimer's disease: up or down, that is the question.

Boonen RA, van Tijn P, Zivkovic D.

Ageing Res Rev. 2009 Apr;8(2):71-82. Epub 2008 Dec 3. Review.PMID: 19101658 [PubMed - indexed for MEDLINE]Related articles

Oligodendrocytes are a Novel Source of Amyloid Peptide Generation.

Skaper SD, Evans NA, Soden PE, Rosin C, Facci L, Richardson JC.

Neurochem Res. 2009 Jun 26. [Epub ahead of print]PMID: 19557514 [PubMed - as supplied by publisher]Related articles

Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.

Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE.

J Exp Biol. 2009 Feb;212(Pt 4):494-8.PMID: 19181896 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease.

Hellström-Lindahl E, Viitanen M, Marutle A.

Neurochem Int. 2009 Sep;55(4):243-52. Epub 2009 Mar 20.PMID: 19524115 [PubMed - indexed for MEDLINE]Related articles