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Mechanisms for human genomic rearrangements.

Gu W, Zhang F, Lupski JR.

Pathogenetics. 2008 Nov 3;1(1):4.PMID: 19014668 [PubMed - in process]Related articlesFree article

Ionizing radiation and genetic risks XIV. Potential research directions in the post-genome era based on knowledge of repair of radiation-induced DNA double-strand breaks in mammalian somatic cells and the origin of deletions associated with human genomic disorders.

Sankaranarayanan K, Wassom JS.

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The genomic basis of disease, mechanisms and assays for genomic disorders.

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Molecular mechanisms for genomic disorders.

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Non-recurrent 17p11.2 deletions are generated by homologous and non-homologous mechanisms.

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Rare pathogenic microdeletions and tandem duplications are microhomology-mediated and stimulated by local genomic architecture.

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Complex human chromosomal and genomic rearrangements.

Zhang F, Carvalho CM, Lupski JR.

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Complex rearrangements in patients with duplications of MECP2 can occur by fork stalling and template switching.

Carvalho CM, Zhang F, Liu P, Patel A, Sahoo T, Bacino CA, Shaw C, Peacock S, Pursley A, Tavyev YJ, Ramocki MB, Nawara M, Obersztyn E, Vianna-Morgante AM, Stankiewicz P, Zoghbi HY, Cheung SW, Lupski JR.

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Genome architecture, rearrangements and genomic disorders.

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Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease.

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Implications of human genome architecture for rearrangement-based disorders: the genomic basis of disease.

Shaw CJ, Lupski JR.

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A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders.

Lee JA, Carvalho CM, Lupski JR.

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Heterogeneous duplications in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and nonhomologous recombination.

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Nonrecurrent MECP2 duplications mediated by genomic architecture-driven DNA breaks and break-induced replication repair.

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The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans.

Zhang F, Khajavi M, Connolly AM, Towne CF, Batish SD, Lupski JR.

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Identification of Uncommon Recurrent Potocki-Lupski Syndrome-Associated Duplications and the Distribution of Rearrangement Types and Mechanisms in PTLS.

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Disorders of the genome architecture: a review.

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Molecular-evolutionary mechanisms for genomic disorders.

Stankiewicz P, Lupski JR.

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Impact of low copy repeats on the generation of balanced and unbalanced chromosomal aberrations in mental retardation.

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