PubMed

Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.

Blum K, Chen AL, Chen TJ, Braverman ER, Reinking J, Blum SH, Cassel K, Downs BW, Waite RL, Williams L, Prihoda TJ, Kerner MM, Palomo T, Comings DE, Tung H, Rhoades P, Oscar-Berman M.

Theor Biol Med Model. 2008 Nov 12;5:24. Review.PMID: 19014506 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART).

Blum K, Chen TJ, Downs BW, Bowirrat A, Waite RL, Braverman ER, Madigan M, Oscar-Berman M, DiNubile N, Stice E, Giordano J, Morse S, Gold M.

Postgrad Med. 2009 Nov;121(6):176-96. Review.PMID: 19940429 [PubMed - indexed for MEDLINE]Related articles

Do dopaminergic gene polymorphisms affect mesolimbic reward activation of music listening response? Therapeutic impact on Reward Deficiency Syndrome (RDS).

Blum K, Chen TJ, Chen AL, Madigan M, Downs BW, Waite RL, Braverman ER, Kerner M, Bowirrat A, Giordano J, Henshaw H, Gold MS.

Med Hypotheses. 2010 Mar;74(3):513-20. Epub 2009 Nov 14.PMID: 19914781 [PubMed - in process]Related articles

Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis.

Blum K, Chen TJ, Meshkin B, Waite RL, Downs BW, Blum SH, Mengucci JF, Arcuri V, Braverman ER, Palomo T.

Med Hypotheses. 2007;69(5):1054-60. Epub 2007 Apr 30.PMID: 17467918 [PubMed - indexed for MEDLINE]Related articles

Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors.

Blum K, Braverman ER, Holder JM, Lubar JF, Monastra VJ, Miller D, Lubar JO, Chen TJ, Comings DE.

J Psychoactive Drugs. 2000 Nov;32 Suppl:i-iv, 1-112. Review.PMID: 11280926 [PubMed - indexed for MEDLINE]Related articles

Reward deficiency syndrome: genetic aspects of behavioral disorders.

Comings DE, Blum K.

Prog Brain Res. 2000;126:325-41. Review.PMID: 11105655 [PubMed - indexed for MEDLINE]Related articles

Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome.

Bowirrat A, Oscar-Berman M.

Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):29-37. Review.PMID: 15457501 [PubMed - indexed for MEDLINE]Related articles

Dopamine D1 and D2 receptor mRNA up-regulation in the caudate-putamen and nucleus accumbens of rat brains by smoking.

Bahk JY, Li S, Park MS, Kim MO.

Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct;26(6):1095-104.PMID: 12452531 [PubMed - indexed for MEDLINE]Related articles

In vivo imaging of synaptic function in the central nervous system: II. Mental and affective disorders.

Nikolaus S, Antke C, Müller HW.

Behav Brain Res. 2009 Dec 1;204(1):32-66. Epub 2009 Jun 10. Review.PMID: 19523495 [PubMed - indexed for MEDLINE]Related articles

Attention-deficit-hyperactivity disorder and reward deficiency syndrome.

Blum K, Chen AL, Braverman ER, Comings DE, Chen TJ, Arcuri V, Blum SH, Downs BW, Waite RL, Notaro A, Lubar J, Williams L, Prihoda TJ, Palomo T, Oscar-Berman M.

Neuropsychiatr Dis Treat. 2008 Oct;4(5):893-918.PMID: 19183781 [PubMed - in process]Related articlesFree article

Alcoholism and the dopaminergic system: a review.

Noble EP.

Addict Biol. 1996;1(4):333-48.PMID: 12893451 [PubMed]Related articles

Narcotic antagonists in drug dependence: pilot study showing enhancement of compliance with SYN-10, amino-acid precursors and enkephalinase inhibition therapy.

Chen TJ, Blum K, Payte JT, Schoolfield J, Hopper D, Stanford M, Braverman ER.

Med Hypotheses. 2004;63(3):538-48.PMID: 15288384 [PubMed - indexed for MEDLINE]Related articles

The D2 dopamine receptor gene as a determinant of reward deficiency syndrome.

Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Cull JG, Comings DE.

J R Soc Med. 1996 Jul;89(7):396-400. Review.PMID: 8774539 [PubMed - indexed for MEDLINE]Related articlesFree article

Dopamine receptors--physiological understanding to therapeutic intervention potential.

Emilien G, Maloteaux JM, Geurts M, Hoogenberg K, Cragg S.

Pharmacol Ther. 1999 Nov;84(2):133-56. Review.PMID: 10596903 [PubMed - indexed for MEDLINE]Related articles

Dopamine and drug addiction: the nucleus accumbens shell connection.

Di Chiara G, Bassareo V, Fenu S, De Luca MA, Spina L, Cadoni C, Acquas E, Carboni E, Valentini V, Lecca D.

Neuropharmacology. 2004;47 Suppl 1:227-41. Review.PMID: 15464140 [PubMed - indexed for MEDLINE]Related articles

The mechanism of action of novel antipsychotic drugs.

Meltzer HY.

Schizophr Bull. 1991;17(2):263-87. Review.PMID: 1679253 [PubMed - indexed for MEDLINE]Related articlesFree article

The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders.

van der Stelt M, Di Marzo V.

Eur J Pharmacol. 2003 Nov 7;480(1-3):133-50. Review.PMID: 14623357 [PubMed - indexed for MEDLINE]Related articles

Effects of chronic alcohol and repeated deprivations on dopamine D1 and D2 receptor levels in the extended amygdala of inbred alcohol-preferring rats.

Sari Y, Bell RL, Zhou FC.

Alcohol Clin Exp Res. 2006 Jan;30(1):46-56.PMID: 16433731 [PubMed - indexed for MEDLINE]Related articles

Genotrim, a DNA-customized nutrigenomic product, targets genetic factors of obesity: hypothesizing a dopamine-glucose correlation demonstrating reward deficiency syndrome (RDS).

Blum K, Chen TJ, Meshkin B, Downs BW, Gordon CA, Blum S, Mangucci JF, Braverman ER, Arcuri V, Deutsch R, Pons MM.

Med Hypotheses. 2007;68(4):844-52. Epub 2006 Oct 27.PMID: 17071010 [PubMed - indexed for MEDLINE]Related articles

Dopamine signaling through D1-like versus D2-like receptors in the nucleus accumbens core versus shell differentially modulates nicotine reward sensitivity.

Laviolette SR, Lauzon NM, Bishop SF, Sun N, Tan H.

J Neurosci. 2008 Aug 6;28(32):8025-33.PMID: 18685027 [PubMed - indexed for MEDLINE]Related articlesFree article