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    Results: 1 to 20 of 138

    1.

    Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease.

    Martin B, Golden E, Carlson OD, Pistell P, Zhou J, Kim W, Frank BP, Thomas S, Chadwick WA, Greig NH, Bates GP, Sathasivam K, Bernier M, Maudsley S, Mattson MP, Egan JM.

    Diabetes. 2009 Feb;58(2):318-28. Epub 2008 Nov 4.PMID: 18984744 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.

    Nguyen T, Hamby A, Massa SM.

    Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11840-5. Epub 2005 Aug 8.PMID: 16087879 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression.

    Andreassen OA, Dedeoglu A, Stanojevic V, Hughes DB, Browne SE, Leech CA, Ferrante RJ, Habener JF, Beal MF, Thomas MK.

    Neurobiol Dis. 2002 Dec;11(3):410-24.PMID: 12586550 [PubMed - indexed for MEDLINE]Related articles

    4.

    Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.

    Ona VO, Li M, Vonsattel JP, Andrews LJ, Khan SQ, Chung WM, Frey AS, Menon AS, Li XJ, Stieg PE, Yuan J, Penney JB, Young AB, Cha JH, Friedlander RM.

    Nature. 1999 May 20;399(6733):263-7.PMID: 10353249 [PubMed - indexed for MEDLINE]Related articles

    5.

    Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice.

    Duan W, Guo Z, Jiang H, Ware M, Li XJ, Mattson MP.

    Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2911-6. Epub 2003 Feb 14.PMID: 12589027 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.

    Peng Q, Masuda N, Jiang M, Li Q, Zhao M, Ross CA, Duan W.

    Exp Neurol. 2008 Mar;210(1):154-63. Epub 2007 Nov 9.PMID: 18096160 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice.

    Pang TY, Stam NC, Nithianantharajah J, Howard ML, Hannan AJ.

    Neuroscience. 2006 Aug 25;141(2):569-84. Epub 2006 May 22.PMID: 16716524 [PubMed - indexed for MEDLINE]Related articles

    8.

    A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

    Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S.

    Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9. Epub 2007 Oct 9.PMID: 17925440 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

    Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.

    Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.PMID: 10434303 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice.

    Dedeoglu A, Kubilus JK, Yang L, Ferrante KL, Hersch SM, Beal MF, Ferrante RJ.

    J Neurochem. 2003 Jun;85(6):1359-67.PMID: 12787055 [PubMed - indexed for MEDLINE]Related articles

    11.

    CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.

    Chou SY, Lee YC, Chen HM, Chiang MC, Lai HL, Chang HH, Wu YC, Sun CN, Chien CL, Lin YS, Wang SC, Tung YY, Chang C, Chern Y.

    J Neurochem. 2005 Apr;93(2):310-20.PMID: 15816854 [PubMed - indexed for MEDLINE]Related articles

    12.

    Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

    Canals JM, Pineda JR, Torres-Peraza JF, Bosch M, Martín-Ibañez R, Muñoz MT, Mengod G, Ernfors P, Alberch J.

    J Neurosci. 2004 Sep 1;24(35):7727-39.PMID: 15342740 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.

    Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW.

    J Neurosci. 2008 Jun 11;28(24):6182-95.PMID: 18550760 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction.

    Weiss A, Roscic A, Paganetti P.

    Mol Neurodegener. 2009 Feb 9;4:11.PMID: 19203385 [PubMed - in process]Related articlesFree article

    15.

    Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain.

    Ginés S, Bosch M, Marco S, Gavaldà N, Díaz-Hernández M, Lucas JJ, Canals JM, Alberch J.

    Eur J Neurosci. 2006 Feb;23(3):649-58.PMID: 16487146 [PubMed - indexed for MEDLINE]Related articles

    16.

    Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease.

    van Dellen A, Cordery PM, Spires TL, Blakemore C, Hannan AJ.

    BMC Neurosci. 2008 Apr 1;9:34.PMID: 18380890 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.

    Tabrizi SJ, Workman J, Hart PE, Mangiarini L, Mahal A, Bates G, Cooper JM, Schapira AH.

    Ann Neurol. 2000 Jan;47(1):80-6.PMID: 10632104 [PubMed - indexed for MEDLINE]Related articles

    18.

    Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.

    Andreassen OA, Dedeoglu A, Ferrante RJ, Jenkins BG, Ferrante KL, Thomas M, Friedlich A, Browne SE, Schilling G, Borchelt DR, Hersch SM, Ross CA, Beal MF.

    Neurobiol Dis. 2001 Jun;8(3):479-91.PMID: 11447996 [PubMed - indexed for MEDLINE]Related articles

    19.

    Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.

    Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM.

    Neurobiol Dis. 2006 Feb;21(2):381-91. Epub 2005 Sep 16.PMID: 16150600 [PubMed - indexed for MEDLINE]Related articles

    20.

    Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes.

    Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y.

    J Neurosci. 2008 Mar 26;28(13):3277-90.PMID: 18367595 [PubMed - indexed for MEDLINE]Related articlesFree article

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