PubMed

Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.

Deering TG, Ogihara T, Trace AP, Maier B, Mirmira RG.

Diabetes. 2009 Jan;58(1):185-93. Epub 2008 Nov 4.PMID: 18984737 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.

Francis J, Chakrabarti SK, Garmey JC, Mirmira RG.

J Biol Chem. 2005 Oct 28;280(43):36244-53. Epub 2005 Sep 1.PMID: 16141209 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.

Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG.

Mol Cell Biol. 2009 Apr;29(8):2053-67. Epub 2009 Feb 23.PMID: 19237535 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific and glucose-responsive expression of the pancreatic derived factor (PANDER) promoter.

Burkhardt BR, Yang MC, Robert CE, Greene SR, McFadden KK, Yang J, Wu J, Gao Z, Wolf BA.

Biochim Biophys Acta. 2005 Sep 25;1730(3):215-25.PMID: 16102856 [PubMed - indexed for MEDLINE]Related articles

Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.

Chakrabarti SK, Francis J, Ziesmann SM, Garmey JC, Mirmira RG.

J Biol Chem. 2003 Jun 27;278(26):23617-23. Epub 2003 Apr 23.PMID: 12711597 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation.

Li Y, Reddy MA, Miao F, Shanmugam N, Yee JK, Hawkins D, Ren B, Natarajan R.

J Biol Chem. 2008 Sep 26;283(39):26771-81. Epub 2008 Jul 23.PMID: 18650421 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.

Iype T, Taylor DG, Ziesmann SM, Garmey JC, Watada H, Mirmira RG.

Mol Endocrinol. 2004 Jun;18(6):1363-75. Epub 2004 Mar 31.PMID: 15056733 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas.

Van Velkinburgh JC, Samaras SE, Gerrish K, Artner I, Stein R.

J Biol Chem. 2005 Nov 18;280(46):38438-44. Epub 2005 Sep 7.PMID: 16147997 [PubMed - indexed for MEDLINE]Related articlesFree article

Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells.

Kataoka K, Shioda S, Ando K, Sakagami K, Handa H, Yasuda K.

J Mol Endocrinol. 2004 Feb;32(1):9-20.PMID: 14765989 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.

Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG.

J Biol Chem. 2005 Apr 29;280(17):16798-807. Epub 2005 Mar 2.PMID: 15743769 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.

Macfarlane WM, Campbell SC, Elrick LJ, Oates V, Bermano G, Lindley KJ, Aynsley-Green A, Dunne MJ, James RF, Docherty K.

J Biol Chem. 2000 May 19;275(20):15330-5.PMID: 10748090 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection.

Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, Bonner-Weir S, Sgroi DC, Weir GC.

Diabetologia. 2007 Feb;50(2):334-42. Epub 2006 Dec 16.PMID: 17180350 [PubMed - indexed for MEDLINE]Related articles

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J.

J Biol Chem. 2005 Nov 11;280(45):37669-80. Epub 2005 Sep 7.PMID: 16148004 [PubMed - indexed for MEDLINE]Related articlesFree article

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. Epub 2005 May 9.PMID: 15883383 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.

Diao J, Asghar Z, Chan CB, Wheeler MB.

J Biol Chem. 2005 Sep 30;280(39):33487-96. Epub 2005 Jul 14.PMID: 16027126 [PubMed - indexed for MEDLINE]Related articlesFree article

A 338-bp proximal fragment of the glucose transporter type 2 (GLUT2) promoter drives reporter gene expression in the pancreatic islets of transgenic mice.

Waeber G, Pedrazzini T, Bonny O, Bonny C, Steinmann M, Nicod P, Haefliger JA.

Mol Cell Endocrinol. 1995 Oct 30;114(1-2):205-15.PMID: 8674846 [PubMed - indexed for MEDLINE]Related articles

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.

Doi A, Shono T, Nishi M, Furuta H, Sasaki H, Nanjo K.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):885-90. Epub 2006 Jan 17.PMID: 16418280 [PubMed - indexed for MEDLINE]Related articlesFree article