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    Results: 1 to 20 of 87

    1.

    In vivo silencing of alpha-synuclein using naked siRNA.

    Lewis J, Melrose H, Bumcrot D, Hope A, Zehr C, Lincoln S, Braithwaite A, He Z, Ogholikhan S, Hinkle K, Kent C, Toudjarska I, Charisse K, Braich R, Pandey RK, Heckman M, Maraganore DM, Crook J, Farrer MJ.

    Mol Neurodegener. 2008 Nov 1;3:19.PMID: 18976489 [PubMed - in process]Related articlesFree article

    2.

    Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.

    Linnertz C, Saucier L, Ge D, Cronin KD, Burke JR, Browndyke JN, Hulette CM, Welsh-Bohmer KA, Chiba-Falek O.

    PLoS One. 2009 Oct 16;4(10):e7480.PMID: 19834617 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    [Relationship between alpha-synuclein and Parkinson's disease]

    Nishioka K, Hattori N.

    Brain Nerve. 2007 Aug;59(8):825-30. Review. Japanese. PMID: 17713118 [PubMed - indexed for MEDLINE]Related articles

    4.

    Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.

    Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, Waucquier N, Defebvre L, Amouyel P, Farrer M, Destée A.

    Lancet. 2004 Sep 25-Oct 1;364(9440):1167-9.PMID: 15451224 [PubMed - indexed for MEDLINE]Related articles

    5.

    Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.

    Fuchs J, Tichopad A, Golub Y, Munz M, Schweitzer KJ, Wolf B, Berg D, Mueller JC, Gasser T.

    FASEB J. 2008 May;22(5):1327-34. Epub 2007 Dec 27.PMID: 18162487 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.

    Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N.

    Ann Neurol. 2006 Feb;59(2):298-309.PMID: 16358335 [PubMed - indexed for MEDLINE]Related articles

    7.

    Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.

    Westerlund M, Belin AC, Anvret A, Håkansson A, Nissbrandt H, Lind C, Sydow O, Olson L, Galter D.

    FASEB J. 2008 Oct;22(10):3509-14. Epub 2008 Jul 7.PMID: 18606870 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Genomic investigation of alpha-synuclein multiplication and parkinsonism.

    Ross OA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton FA, Nishioka K, Fuchs J, Gasser T, Maraganore DM, Adler CH, Larvor L, Chartier-Harlin MC, Nilsson C, Langston JW, Gwinn K, Hattori N, Farrer MJ.

    Ann Neurol. 2008 Jun;63(6):743-50.PMID: 18571778 [PubMed - indexed for MEDLINE]Related articles

    9.

    Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.

    Cronin KD, Ge D, Manninger P, Linnertz C, Rossoshek A, Orrison BM, Bernard DJ, El-Agnaf OM, Schlossmacher MG, Nussbaum RL, Chiba-Falek O.

    Hum Mol Genet. 2009 Sep 1;18(17):3274-85. Epub 2009 Jun 4.PMID: 19498036 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.

    Ikeuchi T, Kakita A, Shiga A, Kasuga K, Kaneko H, Tan CF, Idezuka J, Wakabayashi K, Onodera O, Iwatsubo T, Nishizawa M, Takahashi H, Ishikawa A.

    Arch Neurol. 2008 Apr;65(4):514-9.PMID: 18413475 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Microarray expression analysis of human dopaminergic neuroblastoma cells after RNA interference of SNCA--a key player in the pathogenesis of Parkinson's disease.

    Häbig K, Walter M, Stappert H, Riess O, Bonin M.

    Brain Res. 2009 Feb 23;1256:19-33. Epub 2008 Dec 24.PMID: 19135032 [PubMed - indexed for MEDLINE]Related articles

    12.

    GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.

    Scherzer CR, Grass JA, Liao Z, Pepivani I, Zheng B, Eklund AC, Ney PA, Ng J, McGoldrick M, Mollenhauer B, Bresnick EH, Schlossmacher MG.

    Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10907-12. Epub 2008 Jul 31.PMID: 18669654 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    A single nucleotide polymorphism in the 3'UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease.

    Sotiriou S, Gibney G, Baxevanis AD, Nussbaum RL.

    Neurosci Lett. 2009 Sep 18;461(2):196-201. Epub 2009 Jun 18.PMID: 19540308 [PubMed - indexed for MEDLINE]Related articles

    14.

    alpha-Synuclein multiplication analysis in Italian familial Parkinson disease.

    Sironi F, Trotta L, Antonini A, Zini M, Ciccone R, Della Mina E, Meucci N, Sacilotto G, Primignani P, Brambilla T, Coviello DA, Pezzoli G, Goldwurm S.

    Parkinsonism Relat Disord. 2010 Mar;16(3):228-31. Epub 2009 Oct 14.PMID: 19833540 [PubMed - in process]Related articles

    15.

    Expanding the clinical phenotype of SNCA duplication carriers.

    Nishioka K, Ross OA, Ishii K, Kachergus JM, Ishiwata K, Kitagawa M, Kono S, Obi T, Mizoguchi K, Inoue Y, Imai H, Takanashi M, Mizuno Y, Farrer MJ, Hattori N.

    Mov Disord. 2009 Sep 15;24(12):1811-9.PMID: 19562770 [PubMed - indexed for MEDLINE]Related articles

    16.

    Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice.

    Plaas M, Karis A, Innos J, Rebane E, Baekelandt V, Vaarmann A, Luuk H, Vasar E, Koks S.

    J Physiol Pharmacol. 2008 Jun;59(2):205-16.PMID: 18622040 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms.

    Ibáñez P, Lesage S, Janin S, Lohmann E, Durif F, Destée A, Bonnet AM, Brefel-Courbon C, Heath S, Zelenika D, Agid Y, Dürr A, Brice A; French Parkinson's Disease Genetics Study Group.

    Arch Neurol. 2009 Jan;66(1):102-8.PMID: 19139307 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?

    Fujita M, Sekigawa A, Sekiyama K, Sugama S, Hashimoto M.

    J Neurol. 2009 Aug;256 Suppl 3:286-92. Review.PMID: 19711118 [PubMed - indexed for MEDLINE]Related articles

    19.

    Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons.

    Daher JP, Ying M, Banerjee R, McDonald RS, Hahn MD, Yang L, Flint Beal M, Thomas B, Dawson VL, Dawson TM, Moore DJ.

    Mol Neurodegener. 2009 Jul 24;4:34.PMID: 19630976 [PubMed - in process]Related articlesFree article

    20.

    Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219.

    Clough RL, Dermentzaki G, Stefanis L.

    J Neurochem. 2009 Sep;110(5):1479-90. Epub 2009 Jun 22.PMID: 19549071 [PubMed - indexed for MEDLINE]Related articles

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