PubMed

Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.

Torres TP, Catlin RL, Chan R, Fujimoto Y, Sasaki N, Printz RL, Newgard CB, Shiota M.

Diabetes. 2009 Jan;58(1):78-86. Epub 2008 Oct 24.PMID: 18952838 [PubMed - indexed for MEDLINE]Related articlesFree article

Defect in glucokinase translocation in Zucker diabetic fatty rats.

Fujimoto Y, Donahue EP, Shiota M.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.PMID: 15138155 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats.

Fujimoto Y, Torres TP, Donahue EP, Shiota M.

Diabetes. 2006 Sep;55(9):2479-90.PMID: 16936196 [PubMed - indexed for MEDLINE]Related articlesFree article

A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes.

Shin JS, Torres TP, Catlin RL, Donahue EP, Shiota M.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1381-90. Epub 2007 Jan 4.PMID: 17204595 [PubMed - indexed for MEDLINE]Related articles

Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.

Barzilai N, Hawkins M, Angelov I, Hu M, Rossetti L.

Diabetes. 1996 Oct;45(10):1329-35.PMID: 8826967 [PubMed - indexed for MEDLINE]Related articles

Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds.

Wasan KM, Risovic V, Yuen VG, McNeill JH.

J Trace Elem Med Biol. 2006;19(4):251-8. Epub 2005 Dec 13.PMID: 16443173 [PubMed - indexed for MEDLINE]Related articles

Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.

Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S.

Am J Physiol. 1997 Oct;273(4 Pt 1):E743-50.PMID: 9357804 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

O'Doherty RM, Lehman DL, Télémaque-Potts S, Newgard CB.

Diabetes. 1999 Oct;48(10):2022-7.PMID: 10512368 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555.

Upton R, Widdowson PS, Ishii S, Tanaka H, Williams G.

Br J Pharmacol. 1998 Dec;125(8):1708-14.PMID: 9886762 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin.

Barzilai N, Rossetti L.

J Biol Chem. 1993 Nov 25;268(33):25019-25.PMID: 8227065 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake.

Jiménez-Chillarón JC, Telemaque-Potts S, Gómez-Valadés AG, Anderson P, Newgard CB, Gómez-Foix AM.

Metabolism. 2002 Jan;51(1):121-6.PMID: 11782883 [PubMed - indexed for MEDLINE]Related articles

Opposite effects of hyperglycemia and insulin deficiency on liver glycogen synthase phosphatase activity in the diabetic rat.

Lavoie L, Dimitrakoudis D, Marette A, Annabi B, Klip A, Vranic M, van de Werve G.

Diabetes. 1993 Feb;42(2):363-6.PMID: 8381096 [PubMed - indexed for MEDLINE]Related articles

Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes.

Hawkins M, Gabriely I, Wozniak R, Vilcu C, Shamoon H, Rossetti L.

Diabetes. 2002 Mar;51(3):606-14.PMID: 11872657 [PubMed - indexed for MEDLINE]Related articlesFree article

For the ZDF rat, "Breaking up is hard to do": dissociation of the GK:GKRP complex.

Lange AJ.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1379-80. Epub 2006 Dec 21. No abstract available. PMID: 17185403 [PubMed - indexed for MEDLINE]Related articles

Pathogenesis of hyperglycemia in genetically obese-hyperglycemic rats, Wistar fatty: presence of hepatic insulin resistance.

Sugiyama Y, Shimura Y, Ikeda H.

Endocrinol Jpn. 1989 Feb;36(1):65-73.PMID: 2543549 [PubMed - indexed for MEDLINE]Related articles

Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats.

Burcelin R, Eddouks M, Kande J, Assan R, Girard J.

Biochem J. 1992 Dec 1;288 ( Pt 2):675-9. Erratum in: Biochem J 1993 Feb 1;289(Pt 3):928. PMID: 1463468 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of tungstate, a new potential oral antidiabetic agent, in Zucker diabetic fatty rats.

Muñoz MC, Barberà A, Domínguez J, Fernàndez-Alvarez J, Gomis R, Guinovart JJ.

Diabetes. 2001 Jan;50(1):131-8.PMID: 11147778 [PubMed - indexed for MEDLINE]Related articlesFree article

A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ.

Endocrinology. 2004 Feb;145(2):650-8. Epub 2003 Nov 14.PMID: 14617577 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic intraperitoneal insulin delivery, as compared with subcutaneous delivery, improves hepatic glucose metabolism in streptozotocin diabetic rats.

Mason TM, Gupta N, Goh T, El-Bahrani B, Zannis J, van de Werve G, Giacca A.

Metabolism. 2000 Nov;49(11):1411-6.PMID: 11092503 [PubMed - indexed for MEDLINE]Related articles

Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes.

Clore JN, Stillman J, Sugerman H.

Diabetes. 2000 Jun;49(6):969-74.PMID: 10866049 [PubMed - indexed for MEDLINE]Related articlesFree article