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Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Oresic M, Yki-Järvinen H.

Diabetes. 2009 Jan;58(1):203-8. Epub 2008 Oct 24.PMID: 18952834 [PubMed - indexed for MEDLINE]Related articlesFree article

Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans.

Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, Claussen CD, Fritsche A, Häring HU, Schleicher E.

Diabetologia. 2008 Apr;51(4):648-56. Epub 2008 Feb 20.PMID: 18286258 [PubMed - indexed for MEDLINE]Related articles

A lipidomic analysis of nonalcoholic fatty liver disease.

Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, Cheung O, Sargeant C, Contos MJ, Sanyal AJ.

Hepatology. 2007 Oct;46(4):1081-90.PMID: 17654743 [PubMed - indexed for MEDLINE]Related articles

Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.

Li ZZ, Berk M, McIntyre TM, Feldstein AE.

J Biol Chem. 2009 Feb 27;284(9):5637-44. Epub 2009 Jan 1.PMID: 19119140 [PubMed - indexed for MEDLINE]Related articles

Stearoyl-CoA desaturase--a new player in skeletal muscle metabolism regulation.

Dobrzyń A, Dobrzyń P.

J Physiol Pharmacol. 2006 Nov;57 Suppl 10:31-42. Review.PMID: 17242489 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.

Xu H, Wilcox D, Nguyen P, Voorbach M, Smith H, Brodjian S, Suhar T, Reilly RM, Jacobson PB, Collins CA, Landschulz K, Surowy TK.

Front Biosci. 2007 May 1;12:3781-94.PMID: 17485339 [PubMed - indexed for MEDLINE]Related articles

Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Yki-Järvinen H, Orešič M.

Obesity (Silver Spring). 2009 Oct 1. [Epub ahead of print]PMID: 19798063 [PubMed - as supplied by publisher]Related articles

Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle.

Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E599-607. Epub 2004 Nov 23.PMID: 15562249 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6409-14. Epub 2004 Apr 19.PMID: 15096593 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism.

Kim HJ, Miyazaki M, Ntambi JM.

J Lipid Res. 2002 Oct;43(10):1750-7.PMID: 12364560 [PubMed - indexed for MEDLINE]Related articlesFree article

Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenol.

Kawashima Y, Uy-Yu N, Kozuka H.

Biochem J. 1989 Nov 1;263(3):897-904.PMID: 2574572 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells.

Scaglia N, Igal RA.

J Biol Chem. 2005 Jul 8;280(27):25339-49. Epub 2005 Apr 25.PMID: 15851470 [PubMed - indexed for MEDLINE]Related articlesFree article

The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity.

McNamara RK, Liu Y, Jandacek R, Rider T, Tso P.

Prostaglandins Leukot Essent Fatty Acids. 2008 Apr-May;78(4-5):293-304. Epub 2008 May 21.PMID: 18499418 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver.

Dobrzyn A, Dobrzyn P, Miyazaki M, Sampath H, Chu K, Ntambi JM.

J Biol Chem. 2005 Jun 17;280(24):23356-62. Epub 2005 Apr 13.PMID: 15829484 [PubMed - indexed for MEDLINE]Related articlesFree article

Up-regulated delta 9-desaturase gene expression by hypolipidemic peroxisome-proliferating fatty acids results in increased oleic acid content in liver and VLDL: accumulation of a delta 9-desaturated metabolite of tetradecylthioacetic acid.

Madsen L, Frøyland L, Grav HJ, Berge RK.

J Lipid Res. 1997 Mar;38(3):554-63.PMID: 9101436 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.

Gutiérrez-Juárez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia BP, Rossetti L.

J Clin Invest. 2006 Jun;116(6):1686-95.PMID: 16741579 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study.

Cortez-Pinto H, Chatham J, Chacko VP, Arnold C, Rashid A, Diehl AM.

JAMA. 1999 Nov 3;282(17):1659-64.PMID: 10553793 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry.

Soulard P, McLaughlin M, Stevens J, Connolly B, Coli R, Wang L, Moore J, Kuo MS, LaMarr WA, Ozbal CC, Bhat BG.

Anal Chim Acta. 2008 Oct 3;627(1):105-11. Epub 2008 Apr 15.PMID: 18790133 [PubMed - indexed for MEDLINE]Related articles

Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity.

Dillon R, Greig MJ, Bhat BG.

Anal Chim Acta. 2008 Oct 3;627(1):99-104. Epub 2008 May 15.PMID: 18790132 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.

Kolak M, Westerbacka J, Velagapudi VR, Wågsäter D, Yetukuri L, Makkonen J, Rissanen A, Häkkinen AM, Lindell M, Bergholm R, Hamsten A, Eriksson P, Fisher RM, Oresic M, Yki-Järvinen H.

Diabetes. 2007 Aug;56(8):1960-8. Epub 2007 Jul 9.PMID: 17620421 [PubMed - indexed for MEDLINE]Related articlesFree article