PubMed

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin.

Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe CG, Langen R, Chen J.

Mol Neurodegener. 2008 Oct 21;3:16.PMID: 18939994 [PubMed - in process]Related articlesFree article

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.

Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG.

Mol Neurodegener. 2007 Sep 26;2:18.PMID: 17897471 [PubMed - in process]Related articlesFree article

Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.

Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J.

J Clin Invest. 2006 Feb;116(2):378-85.PMID: 16453022 [PubMed - indexed for MEDLINE]Related articlesFree article

Soluble and mature amyloid fibrils in drusen deposits.

Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1304-10. Epub 2009 Nov 5.PMID: 19892876 [PubMed - in process]Related articles

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction.

Tomic JL, Pensalfini A, Head E, Glabe CG.

Neurobiol Dis. 2009 Sep;35(3):352-8. Epub 2009 Jun 10.PMID: 19523517 [PubMed - indexed for MEDLINE]Related articles

Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231).

Martins SM, Frosoni DJ, Martinez AM, De Felice FG, Ferreira ST.

J Biol Chem. 2006 Sep 8;281(36):26121-8. Epub 2006 Jul 13.PMID: 16844683 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration.

Anderson DH, Talaga KC, Rivest AJ, Barron E, Hageman GS, Johnson LV.

Exp Eye Res. 2004 Feb;78(2):243-56.PMID: 14729357 [PubMed - indexed for MEDLINE]Related articles

Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation.

Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C.

J Biol Chem. 2010 Feb 26;285(9):6071-9. Epub 2009 Dec 15.PMID: 20018889 [PubMed - in process]Related articles

[Alzheimer disease: cellular and molecular aspects]

Octave JN.

Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French. PMID: 16768248 [PubMed - indexed for MEDLINE]Related articles

Peptide and protein mimetics inhibiting amyloid beta-peptide aggregation.

Takahashi T, Mihara H.

Acc Chem Res. 2008 Oct;41(10):1309-18.PMID: 18937396 [PubMed - indexed for MEDLINE]Related articles

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.

J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7.PMID: 15590663 [PubMed - indexed for MEDLINE]Related articlesFree article

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

Ferreira ST, Vieira MN, De Felice FG.

IUBMB Life. 2007 Apr-May;59(4-5):332-45. Review.PMID: 17505973 [PubMed - indexed for MEDLINE]Related articles

A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain.

Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E.

Acta Neuropathol. 2009 Oct;118(4):505-17. Epub 2009 Apr 10.PMID: 19360426 [PubMed - indexed for MEDLINE]Related articlesFree article

Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases.

Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, Glabe CG.

J Biol Chem. 2004 Nov 5;279(45):46363-6. Epub 2004 Sep 21.PMID: 15385542 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformation-dependent anti-amyloid oligomer antibodies.

Kayed R, Glabe CG.

Methods Enzymol. 2006;413:326-44.PMID: 17046404 [PubMed - indexed for MEDLINE]Related articles

Amyloid oligomer conformation in a group of natively folded proteins.

Yoshiike Y, Minai R, Matsuo Y, Chen YR, Kimura T, Takashima A.

PLoS One. 2008 Sep 18;3(9):e3235.PMID: 18800165 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins.

Meredith SC.

Ann N Y Acad Sci. 2005 Dec;1066:181-221. Review.PMID: 16533927 [PubMed - indexed for MEDLINE]Related articles

The intact human acetylcholinesterase C-terminal oligomerization domain is alpha-helical in situ and in isolation, but a shorter fragment forms beta-sheet-rich amyloid fibrils and protofibrillar oligomers.

Cottingham MG, Voskuil JL, Vaux DJ.

Biochemistry. 2003 Sep 16;42(36):10863-73.PMID: 12962511 [PubMed - indexed for MEDLINE]Related articles

Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.

Watson D, Castaño E, Kokjohn TA, Kuo YM, Lyubchenko Y, Pinsky D, Connolly ES Jr, Esh C, Luehrs DC, Stine WB, Rowse LM, Emmerling MR, Roher AE.

Neurol Res. 2005 Dec;27(8):869-81. Review.PMID: 16354549 [PubMed - indexed for MEDLINE]Related articles

Ex situ atomic force microscopy analysis of beta-amyloid self-assembly and deposition on a synthetic template.

Ha C, Park CB.

Langmuir. 2006 Aug 1;22(16):6977-85.PMID: 16863248 [PubMed - indexed for MEDLINE]Related articles