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    Results: 1 to 20 of 179

    1.

    Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.

    Arita R, Hata Y, Nakao S, Kita T, Miura M, Kawahara S, Zandi S, Almulki L, Tayyari F, Shimokawa H, Hafezi-Moghadam A, Ishibashi T.

    Diabetes. 2009 Jan;58(1):215-26. Epub 2008 Oct 7.PMID: 18840783 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.

    Koshikawa S, Nishikimi T, Inaba C, Akimoto K, Matsuoka H.

    J Hypertens. 2008 Sep;26(9):1837-48.PMID: 18698220 [PubMed - indexed for MEDLINE]Related articles

    3.

    Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo.

    Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP.

    Am J Pathol. 2002 Feb;160(2):501-9.PMID: 11839570 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway.

    Chen XY, Dun JN, Miao QF, Zhang YJ.

    Pharmacology. 2009;83(2):67-79. Epub 2008 Dec 4.PMID: 19052484 [PubMed - indexed for MEDLINE]Related articles

    5.

    Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

    Hamid SA, Bower HS, Baxter GF.

    Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2598-606. Epub 2007 Jan 12.PMID: 17220176 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina.

    Yokota T, Utsunomiya K, Taniguchi K, Gojo A, Kurata H, Tajima N.

    Jpn J Ophthalmol. 2007 Nov-Dec;51(6):424-30. Epub 2007 Dec 21.PMID: 18158592 [PubMed - indexed for MEDLINE]Related articles

    7.

    [Preventive strategy for the treatment of diabetic vitreoretinopathy]

    Hata Y.

    Nippon Ganka Gakkai Zasshi. 2009 Mar;113(3):379-401; discussion 402. Japanese. PMID: 19348184 [PubMed - indexed for MEDLINE]Related articles

    8.

    Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.

    Kolavennu V, Zeng L, Peng H, Wang Y, Danesh FR.

    Diabetes. 2008 Mar;57(3):714-23. Epub 2007 Dec 14.PMID: 18083785 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.

    Anegawa G, Kawanaka H, Yoshida D, Konishi K, Yamaguchi S, Kinjo N, Taketomi A, Hashizume M, Shimokawa H, Maehara Y.

    Hepatology. 2008 Mar;47(3):966-77.PMID: 18167063 [PubMed - indexed for MEDLINE]Related articles

    10.

    RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction.

    Bivalacqua TJ, Champion HC, Usta MF, Cellek S, Chitaley K, Webb RC, Lewis RL, Mills TM, Hellstrom WJ, Kadowitz PJ.

    Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9121-6. Epub 2004 Jun 7.PMID: 15184671 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.

    Rikitake Y, Kim HH, Huang Z, Seto M, Yano K, Asano T, Moskowitz MA, Liao JK.

    Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1.PMID: 16141422 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor.

    Hata Y, Miura M, Nakao S, Kawahara S, Kita T, Ishibashi T.

    Jpn J Ophthalmol. 2008 Jan-Feb;52(1):16-23. Epub 2008 Mar 28.PMID: 18369695 [PubMed - indexed for MEDLINE]Related articles

    13.

    Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.

    Li F, Xia W, Li A, Zhao C, Sun R.

    Pharmacol Res. 2007 Jan;55(1):64-71. Epub 2006 Nov 1.PMID: 17127075 [PubMed - indexed for MEDLINE]Related articles

    14.

    Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model.

    Park K, Kim SW, Rhu KS, Paick JS.

    J Sex Med. 2006 Nov;3(6):996-1003.PMID: 17100932 [PubMed - indexed for MEDLINE]Related articles

    15.

    Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.

    Tiftik RN, Erol A, Cnar MG, Kubat H, Ark M, Ulker S, Büyükafşar K.

    J Cardiovasc Pharmacol. 2008 Feb;51(2):140-7.PMID: 18287881 [PubMed - indexed for MEDLINE]Related articles

    16.

    Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes.

    Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, Luscinskas FW, Adamis AP.

    Invest Ophthalmol Vis Sci. 2000 Apr;41(5):1153-8.PMID: 10752954 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.

    Thorlacius K, Slotta JE, Laschke MW, Wang Y, Menger MD, Jeppsson B, Thorlacius H.

    J Leukoc Biol. 2006 May;79(5):923-31.PMID: 16641138 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.

    Yin L, Morishige K, Takahashi T, Hashimoto K, Ogata S, Tsutsumi S, Takata K, Ohta T, Kawagoe J, Takahashi K, Kurachi H.

    Mol Cancer Ther. 2007 May;6(5):1517-25.PMID: 17513600 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.

    Kitaoka Y, Kitaoka Y, Kumai T, Lam TT, Kuribayashi K, Isenoumi K, Munemasa Y, Motoki M, Kobayashi S, Ueno S.

    Brain Res. 2004 Aug 20;1018(1):111-8.PMID: 15262212 [PubMed - indexed for MEDLINE]Related articles

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