PubMed

The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors.

Rossi F, Querido B, Nimmagadda M, Cocklin S, Navas-Martín S, Martín-García J.

Retrovirology. 2008 Oct 6;5:89.PMID: 18837996 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor.

Martín-García J, Cao W, Varela-Rohena A, Plassmeyer ML, González-Scarano F.

Virology. 2006 Mar 1;346(1):169-79. Epub 2005 Nov 23.PMID: 16309726 [PubMed - indexed for MEDLINE]Related articles

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

Peters PJ, Duenas-Decamp MJ, Sullivan WM, Brown R, Ankghuambom C, Luzuriaga K, Robinson J, Burton DR, Bell J, Simmonds P, Ball J, Clapham PR.

Retrovirology. 2008 Jan 18;5:5.PMID: 18205925 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages.

Peters PJ, Bhattacharya J, Hibbitts S, Dittmar MT, Simmons G, Bell J, Simmonds P, Clapham PR.

J Virol. 2004 Jul;78(13):6915-26. Erratum in: J Virol. 2005 Mar;79(5):3227. PMID: 15194768 [PubMed - indexed for MEDLINE]Related articlesFree article

The V1/V2 region of human immunodeficiency virus type 1 modulates the sensitivity to neutralization by soluble CD4 and cellular tropism.

Morikita T, Maeda Y, Fujii S, Matsushita S, Obaru K, Takatsuki K.

AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1291-9.PMID: 9339846 [PubMed - indexed for MEDLINE]Related articles

Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.

Thomas ER, Dunfee RL, Stanton J, Bogdan D, Taylor J, Kunstman K, Bell JE, Wolinsky SM, Gabuzda D.

Virology. 2007 Mar 30;360(1):105-19. Epub 2006 Nov 7.PMID: 17084877 [PubMed - indexed for MEDLINE]Related articlesFree article

Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes.

Duenas-Decamp MJ, Peters PJ, Burton D, Clapham PR.

J Virol. 2009 Mar;83(6):2575-83. Epub 2009 Jan 7.PMID: 19129457 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain.

Gray L, Roche M, Churchill MJ, Sterjovski J, Ellett A, Poumbourios P, Sherieff S, Wang B, Saksena N, Purcell DF, Wesselingh S, Cunningham AL, Brew BJ, Gabuzda D, Gorry PR.

J Virol. 2009 Jun;83(11):5430-41. Epub 2009 Mar 25. Erratum in: J Virol. 2009 Aug;83(15):7794. Sheffief, Shameem [corrected to Sherieff, Shameem]. PMID: 19321618 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages.

Sundaravaradan V, Das SR, Ramakrishnan R, Sehgal S, Gopalan S, Ahmad N, Jameel S.

Virol J. 2007 Nov 24;4:126.PMID: 18036244 [PubMed - indexed for MEDLINE]Related articlesFree article

Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.

Means RE, Matthews T, Hoxie JA, Malim MH, Kodama T, Desrosiers RC.

J Virol. 2001 Apr;75(8):3903-15.PMID: 11264379 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in and discrepancies between cell tropisms and coreceptor uses of human immunodeficiency virus type 1 induced by single point mutations at the V3 tip of the env protein.

Shimizu N, Haraguchi Y, Takeuchi Y, Soda Y, Kanbe K, Hoshino H.

Virology. 1999 Jul 5;259(2):324-33.PMID: 10388657 [PubMed - indexed for MEDLINE]Related articles

Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate.

Martín J, LaBranche CC, González-Scarano F.

J Virol. 2001 Apr;75(8):3568-80.PMID: 11264346 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages.

Walter BL, Wehrly K, Swanstrom R, Platt E, Kabat D, Chesebro B.

J Virol. 2005 Apr;79(8):4828-37.PMID: 15795268 [PubMed - indexed for MEDLINE]Related articlesFree article

The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.

Dunfee RL, Thomas ER, Gorry PR, Wang J, Taylor J, Kunstman K, Wolinsky SM, Gabuzda D.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15160-5. Epub 2006 Oct 2.PMID: 17015824 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of V3 independent domains on a dualtropic human immunodeficiency virus type 1 (HIV-1) envelope gp120 in CCR5 coreceptor utilization and viral infectivity.

Foda M, Harada S, Maeda Y.

Microbiol Immunol. 2001;45(7):521-30.PMID: 11529558 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of determinants on a dualtropic human immunodeficiency virus type 1 envelope glycoprotein that confer usage of CXCR4.

Cho MW, Lee MK, Carney MC, Berson JF, Doms RW, Martin MA.

J Virol. 1998 Mar;72(3):2509-15.PMID: 9499115 [PubMed - indexed for MEDLINE]Related articlesFree article

Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS.

Sterjovski J, Churchill MJ, Ellett A, Gray LR, Roche MJ, Dunfee RL, Purcell DF, Saksena N, Wang B, Sonza S, Wesselingh SL, Karlsson I, Fenyo EM, Gabuzda D, Cunningham AL, Gorry PR.

Retrovirology. 2007 Dec 12;4:89.PMID: 18076768 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.

Koito A, Harrowe G, Levy JA, Cheng-Mayer C.

J Virol. 1994 Apr;68(4):2253-9.PMID: 8139010 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues.

Peters PJ, Dueñas-Decamp MJ, Sullivan WM, Clapham PR.

J Neuroimmune Pharmacol. 2007 Mar;2(1):32-41. Epub 2006 Nov 7. Review.PMID: 18040824 [PubMed - indexed for MEDLINE]Related articles

Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity.

Gorry PR, Bristol G, Zack JA, Ritola K, Swanstrom R, Birch CJ, Bell JE, Bannert N, Crawford K, Wang H, Schols D, De Clercq E, Kunstman K, Wolinsky SM, Gabuzda D.

J Virol. 2001 Nov;75(21):10073-89.PMID: 11581376 [PubMed - indexed for MEDLINE]Related articlesFree article