PubMed

Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice.

Chen JX, Stinnett A.

Diabetes. 2008 Dec;57(12):3335-43. Epub 2008 Oct 3.PMID: 18835934 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases.

Knowles HJ, Tian YM, Mole DR, Harris AL.

Circ Res. 2004 Jul 23;95(2):162-9. Epub 2004 Jun 10.PMID: 15192023 [PubMed - indexed for MEDLINE]Related articlesFree article

Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells.

Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW.

J Cell Physiol. 2008 Nov;217(2):319-27.PMID: 18506785 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of Ang-1/Tie-2 signaling contributes to the impaired myocardial vascular maturation and angiogenesis in type II diabetic mice.

Chen JX, Stinnett A.

Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1606-13. Epub 2008 Jun 12.PMID: 18556567 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.

Loinard C, Ginouvès A, Vilar J, Cochain C, Zouggari Y, Recalde A, Duriez M, Lévy BI, Pouysségur J, Berra E, Silvestre JS.

Circulation. 2009 Jul 7;120(1):50-9. Epub 2009 Jun 22.PMID: 19546390 [PubMed - indexed for MEDLINE]Related articles

Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury.

Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA 3rd.

Circ Res. 2006 Jan 6;98(1):133-40. Epub 2005 Nov 23.PMID: 16306444 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.

McMahon S, Charbonneau M, Grandmont S, Richard DE, Dubois CM.

J Biol Chem. 2006 Aug 25;281(34):24171-81. Epub 2006 Jun 30.PMID: 16815840 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

Takeda K, Cowan A, Fong GH.

Circulation. 2007 Aug 14;116(7):774-81. Epub 2007 Jul 23.PMID: 17646578 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression.

Bitto A, Minutoli L, Galeano MR, Altavilla D, Polito F, Fiumara T, Calò M, Lo Cascio P, Zentilin L, Giacca M, Squadrito F.

Clin Sci (Lond). 2008 Jun;114(12):707-18.PMID: 18078386 [PubMed - indexed for MEDLINE]Related articles

Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.

Wu S, Nishiyama N, Kano MR, Morishita Y, Miyazono K, Itaka K, Chung UI, Kataoka K.

Mol Ther. 2008 Jul;16(7):1227-34. Epub 2008 May 20.PMID: 18500250 [PubMed - indexed for MEDLINE]Related articles

Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.

Pajusola K, Künnapuu J, Vuorikoski S, Soronen J, André H, Pereira T, Korpisalo P, Ylä-Herttuala S, Poellinger L, Alitalo K.

FASEB J. 2005 Aug;19(10):1365-7. Epub 2005 Jun 15.PMID: 15958522 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair.

Komatsu DE, Hadjiargyrou M.

Bone. 2004 Apr;34(4):680-8.PMID: 15050899 [PubMed - indexed for MEDLINE]Related articles

Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions.

Floyd ZE, Kilroy G, Wu X, Gimble JM.

J Cell Biochem. 2007 Aug 15;101(6):1545-57.PMID: 17370314 [PubMed - indexed for MEDLINE]Related articles

Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1alpha and VEGF.

Jiang J, Xia XB, Xu HZ, Xiong Y, Song WT, Xiong SQ, Li Y.

J Cell Physiol. 2009 Jan;218(1):66-74.PMID: 18767037 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors.

Yamakawa M, Liu LX, Date T, Belanger AJ, Vincent KA, Akita GY, Kuriyama T, Cheng SH, Gregory RJ, Jiang C.

Circ Res. 2003 Oct 3;93(7):664-73. Epub 2003 Sep 4.PMID: 12958144 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair.

Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM.

Wound Repair Regen. 2007 Sep-Oct;15(5):636-45.PMID: 17971009 [PubMed - indexed for MEDLINE]Related articles

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL.

Circ Res. 2003 Nov 28;93(11):1074-81. Epub 2003 Oct 23.PMID: 14576200 [PubMed - indexed for MEDLINE]Related articlesFree article

Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia.

Thackaberry EA, Gabaldon DM, Walker MK, Smith SM.

Cardiovasc Toxicol. 2002;2(4):263-74.PMID: 12665660 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

Berchner-Pfannschmidt U, Yamac H, Trinidad B, Fandrey J.

J Biol Chem. 2007 Jan 19;282(3):1788-96. Epub 2006 Oct 23.PMID: 17060326 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas.

Jensen RL, Ragel BT, Whang K, Gillespie D.

J Neurooncol. 2006 Jul;78(3):233-47. Epub 2006 Apr 13.PMID: 16612574 [PubMed - indexed for MEDLINE]Related articles