PubMed

Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.

Mirnics K, Norstrom EM, Garbett K, Choi SH, Zhang X, Ebert P, Sisodia SS.

Mol Neurodegener. 2008 Oct 3;3:14.PMID: 18834536 [PubMed - in process]Related articlesFree article

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J.

J Biol Chem. 2004 Nov 5;279(45):46907-14. Epub 2004 Sep 1.PMID: 15345711 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos.

Nornes S, Groth C, Camp E, Ey P, Lardelli M.

Exp Cell Res. 2003 Sep 10;289(1):124-32.PMID: 12941610 [PubMed - indexed for MEDLINE]Related articles

Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis.

Newman M, Tucker B, Nornes S, Ward A, Lardelli M.

J Alzheimers Dis. 2009 Jan;16(1):133-47.PMID: 19158429 [PubMed - indexed for MEDLINE]Related articles

Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain.

Madsen LB, Thomsen B, Larsen K, Bendixen C, Holm IE, Fredholm M, Jørgensen AL, Nielsen AL.

BMC Neurosci. 2007 Sep 13;8:72.PMID: 17854491 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathological and physiological functions of presenilins.

Vetrivel KS, Zhang YW, Xu H, Thinakaran G.

Mol Neurodegener. 2006 Jun 12;1:4.PMID: 16930451 [PubMed]Related articlesFree article

Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secreted Amyloid-beta Protein Precursor Generated by beta-Secretase Cleavage.

Zhang C, Browne A, Kim DY, Tanzi RE.

Curr Alzheimer Res. 2009 Dec 1. [Epub ahead of print]PMID: 19715549 [PubMed - as supplied by publisher]Related articles

Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity.

Nornes S, Newman M, Verdile G, Wells S, Stoick-Cooper CL, Tucker B, Frederich-Sleptsova I, Martins R, Lardelli M.

Hum Mol Genet. 2008 Feb 1;17(3):402-12. Epub 2007 Nov 2.PMID: 17981814 [PubMed - indexed for MEDLINE]Related articlesFree article

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.

Nornes S, Newman M, Wells S, Verdile G, Martins RN, Lardelli M.

Exp Cell Res. 2009 Oct 1;315(16):2791-801. Epub 2009 Jun 27.PMID: 19563801 [PubMed - indexed for MEDLINE]Related articles

Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice.

Gu F, Zhu M, Shi J, Hu Y, Zhao Z.

Neurosci Lett. 2008 Jul 25;440(1):44-8. Epub 2008 May 18.PMID: 18539391 [PubMed - indexed for MEDLINE]Related articles

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.

Tabuchi K, Chen G, Südhof TC, Shen J.

J Neurosci. 2009 Jun 3;29(22):7290-301.PMID: 19494151 [PubMed - indexed for MEDLINE]Related articlesFree article

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.

Dong S, Li C, Wu P, Tsien JZ, Hu Y.

Eur J Neurosci. 2007 Jul;26(1):101-12.PMID: 17614943 [PubMed - indexed for MEDLINE]Related articles

Three-year follow-up of a patient with early-onset Alzheimer's disease with presenilin-2 N141I mutation - case report and review of the literature.

Nikisch G, Hertel A, Kiessling B, Wagner T, Krasz D, Hofmann E, Wiedemann G.

Eur J Med Res. 2008 Dec 3;13(12):579-84. Review.PMID: 19073399 [PubMed - indexed for MEDLINE]Related articles

Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.

Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE.

J Exp Biol. 2009 Feb;212(Pt 4):494-8.PMID: 19181896 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.

Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.

J Neurochem. 2009 Jul;110(1):275-83. Epub 2009 Apr 29.PMID: 19457123 [PubMed - indexed for MEDLINE]Related articles

Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.

Kallhoff-Munoz V, Hu L, Chen X, Pautler RG, Zheng H.

J Neurosci. 2008 Oct 29;28(44):11421-31.PMID: 18971484 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiles of APP and BACE1 in Tg SOD1G93A cortical cells.

Spadoni O, Crestini A, Piscopo P, Malvezzi-Campeggi L, Carunchio I, Pieri M, Zona C, Confaloni A.

Cell Mol Neurobiol. 2009 Jul;29(5):635-41. Epub 2009 Feb 13.PMID: 19214738 [PubMed - indexed for MEDLINE]Related articles

[Genetics of dementias, Part 4: a spectrum of mutations responsible for the familial autosomal dominant form of Alzheimer's disease]

Kowalska A.

Postepy Hig Med Dosw (Online). ;63:583-91. Polish. PMID: 20009122 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologue.

Ounallah-Saad H, Beeri R, Goshen I, Yirmiya R, Renbaum P, Levy-Lahad E.

Gene. 2009 Oct 15;446(2):81-9. Epub 2009 Jun 30.PMID: 19573580 [PubMed - indexed for MEDLINE]Related articles

Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI.

Maheswaran S, Barjat H, Rueckert D, Bate ST, Howlett DR, Tilling L, Smart SC, Pohlmann A, Richardson JC, Hartkens T, Hill DL, Upton N, Hajnal JV, James MF.

Brain Res. 2009 May 13;1270:19-32. Epub 2009 Mar 9.PMID: 19272356 [PubMed - indexed for MEDLINE]Related articles