PubMed

Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.

Petrushina I, Ghochikyan A, Mkrtichyan M, Mamikonyan G, Movsesyan N, Ajdari R, Vasilevko V, Karapetyan A, Lees A, Agadjanyan MG, Cribbs DH.

J Neuroinflammation. 2008 Sep 29;5:42.PMID: 18823564 [PubMed - indexed for MEDLINE]Related articlesFree article

Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages.

Asuni AA, Boutajangout A, Scholtzova H, Knudsen E, Li YS, Quartermain D, Frangione B, Wisniewski T, Sigurdsson EM.

Eur J Neurosci. 2006 Nov;24(9):2530-42.PMID: 17100841 [PubMed - indexed for MEDLINE]Related articlesFree article

Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.

Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG.

J Neurosci. 2007 Nov 14;27(46):12721-31.PMID: 18003852 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid.

Wilcock DM, Jantzen PT, Li Q, Morgan D, Gordon MN.

Neuroscience. 2007 Feb 9;144(3):950-60. Epub 2006 Nov 28.PMID: 17137722 [PubMed - indexed for MEDLINE]Related articlesFree article

Active immunization of mice with an Abeta-Hsp70 vaccine.

Koller MF, Mohajeri MH, Huber M, Wollmer MA, Roth Z'graggen BV, Sandmeier E, Moritz E, Tracy J, Nitsch RM, Christen P.

Neurodegener Dis. 2004;1(1):20-8.PMID: 16908970 [PubMed - indexed for MEDLINE]Related articles

Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.

Ghochikyan A, Mkrtichyan M, Petrushina I, Movsesyan N, Karapetyan A, Cribbs DH, Agadjanyan MG.

Vaccine. 2006 Mar 20;24(13):2275-82. Epub 2005 Dec 5.PMID: 16368167 [PubMed - indexed for MEDLINE]Related articlesFree article

Active immunization trial in Abeta42-injected P301L tau transgenic mice.

Kulic L, Kurosinski P, Chen F, Tracy J, Mohajeri MH, Li H, Nitsch RM, Götz J.

Neurobiol Dis. 2006 Apr;22(1):50-6. Epub 2005 Nov 11.PMID: 16289870 [PubMed - indexed for MEDLINE]Related articles

Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease.

Qu B, Rosenberg RN, Li L, Boyer PJ, Johnston SA.

Arch Neurol. 2004 Dec;61(12):1859-64.PMID: 15596606 [PubMed - indexed for MEDLINE]Related articlesFree article

Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM.

J Neurosci. 2005 Mar 16;25(11):2803-10.PMID: 15772340 [PubMed - indexed for MEDLINE]Related articlesFree article

Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease.

Dickstein DL, Biron KE, Ujiie M, Pfeifer CG, Jeffries AR, Jefferies WA.

FASEB J. 2006 Mar;20(3):426-33. Erratum in: FASEB J. 2006 Jul;20(9):1573. PMID: 16507760 [PubMed - indexed for MEDLINE]Related articlesFree article

Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.

Maier M, Seabrook TJ, Lazo ND, Jiang L, Das P, Janus C, Lemere CA.

J Neurosci. 2006 May 3;26(18):4717-28.PMID: 16672644 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels.

Rakover I, Arbel M, Solomon B.

Neurodegener Dis. 2007;4(5):392-402. Epub 2007 May 25.PMID: 17536186 [PubMed - indexed for MEDLINE]Related articles

CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.

Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J.

Neurobiol Dis. 2008 Feb;29(2):336-53. Epub 2007 Oct 16.PMID: 18055209 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice.

Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE.

J Neurosci. 2003 Sep 17;23(24):8532-8.PMID: 13679422 [PubMed - indexed for MEDLINE]Related articlesFree article

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA.

Brain. 2008 Dec;131(Pt 12):3299-310. Epub 2008 Oct 25.PMID: 18953056 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.

Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE.

Neurobiol Aging. 2001 Sep-Oct;22(5):721-7.PMID: 11705631 [PubMed - indexed for MEDLINE]Related articles

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.

J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7.PMID: 15590663 [PubMed - indexed for MEDLINE]Related articlesFree article

Abeta-immunotherapy for Alzheimer's disease using mannan-amyloid-Beta peptide immunoconjugates.

Ghochikyan A, Petrushina I, Lees A, Vasilevko V, Movsesyan N, Karapetyan A, Agadjanyan MG, Cribbs DH.

DNA Cell Biol. 2006 Oct;25(10):571-80.PMID: 17132088 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.

Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM.

BMC Neurosci. 2007 Jul 24;8:54.PMID: 17650315 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease.

Kim HD, Jin JJ, Maxwell JA, Fukuchi K.

Immunol Lett. 2007 Sep 15;112(1):30-8. Epub 2007 Jul 23.PMID: 17686533 [PubMed - indexed for MEDLINE]Related articlesFree article