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Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system.

Proulx K, Cota D, Woods SC, Seeley RJ.

Diabetes. 2008 Dec;57(12):3231-8. Epub 2008 Sep 5.PMID: 18776140 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.

Cota D, Matter EK, Woods SC, Seeley RJ.

J Neurosci. 2008 Jul 9;28(28):7202-8.PMID: 18614690 [PubMed - indexed for MEDLINE]Related articlesFree article

C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase.

Kim EK, Miller I, Aja S, Landree LE, Pinn M, McFadden J, Kuhajda FP, Moran TH, Ronnett GV.

J Biol Chem. 2004 May 7;279(19):19970-6. Epub 2004 Mar 17.PMID: 15028725 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion.

Clegg DJ, Wortman MD, Benoit SC, McOsker CC, Seeley RJ.

Diabetes. 2002 Nov;51(11):3196-201.PMID: 12401710 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic mTOR signaling regulates food intake.

Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ.

Science. 2006 May 12;312(5775):927-30.PMID: 16690869 [PubMed - indexed for MEDLINE]Related articlesFree article

C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism.

Landree LE, Hanlon AL, Strong DW, Rumbaugh G, Miller IM, Thupari JN, Connolly EC, Huganir RL, Richardson C, Witters LA, Kuhajda FP, Ronnett GV.

J Biol Chem. 2004 Jan 30;279(5):3817-27. Epub 2003 Nov 13.PMID: 14615481 [PubMed - indexed for MEDLINE]Related articlesFree article

FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens.

Dridi S, Ververken C, Hillgartner FB, Arckens L, Van der Gucht E, Cnops L, Decuypere E, Buyse J.

Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R138-47. Epub 2006 Feb 2. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R860. Lutgarde, Arckens [corrected to Arckens, Lutgarde]. PMID: 16455759 [PubMed - indexed for MEDLINE]Related articles

Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status.

Villanueva EC, Münzberg H, Cota D, Leshan RL, Kopp K, Ishida-Takahashi R, Jones JC, Fingar DC, Seeley RJ, Myers MG Jr.

Endocrinology. 2009 Oct;150(10):4541-51. Epub 2009 Jul 23.PMID: 19628573 [PubMed - indexed for MEDLINE]Related articles

RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells.

Menendez JA, Lupu R.

Int J Mol Med. 2005 Jan;15(1):33-40.PMID: 15583825 [PubMed - indexed for MEDLINE]Related articles

Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight.

Aja S, Landree LE, Kleman AM, Medghalchi SM, Vadlamudi A, McFadden JM, Aplasca A, Hyun J, Plummer E, Daniels K, Kemm M, Townsend CA, Thupari JN, Kuhajda FP, Moran TH, Ronnett GV.

Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R352-61. Epub 2007 Dec 5.PMID: 18056987 [PubMed - indexed for MEDLINE]Related articles

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.

Beugnet A, Tee AR, Taylor PM, Proud CG.

Biochem J. 2003 Jun 1;372(Pt 2):555-66. Erratum in: Biochem J. 2003 Aug 1;373(Pt 3):999. PMID: 12611592 [PubMed - indexed for MEDLINE]Related articlesFree article

C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure.

Tu Y, Thupari JN, Kim EK, Pinn ML, Moran TH, Ronnett GV, Kuhajda FP.

Endocrinology. 2005 Jan;146(1):486-93. Epub 2004 Oct 21.PMID: 15498887 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland.

Suh JM, Song JH, Kim DW, Kim H, Chung HK, Hwang JH, Kim JM, Hwang ES, Chung J, Han JH, Cho BY, Ro HK, Shong M.

J Biol Chem. 2003 Jun 13;278(24):21960-71. Epub 2003 Mar 30.PMID: 12668683 [PubMed - indexed for MEDLINE]Related articlesFree article

The connections between C75 and obesity drug-target pathways.

Kuhajda FP, Landree LE, Ronnett GV.

Trends Pharmacol Sci. 2005 Nov;26(11):541-4. Epub 2005 Sep 16.PMID: 16169094 [PubMed - indexed for MEDLINE]Related articles

Fatty acid metabolism, the central nervous system, and feeding.

Ronnett GV, Kleman AM, Kim EK, Landree LE, Tu Y.

Obesity (Silver Spring). 2006 Aug;14 Suppl 5:201S-207S. Review.PMID: 17021367 [PubMed - indexed for MEDLINE]Related articles

L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport.

Peyrollier K, Hajduch E, Blair AS, Hyde R, Hundal HS.

Biochem J. 2000 Sep 1;350 Pt 2:361-8.PMID: 10947949 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.

Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R.

Int J Oncol. 2004 Mar;24(3):591-608.PMID: 14767544 [PubMed - indexed for MEDLINE]Related articles

Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.

Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR.

J Nutr. 2000 Oct;130(10):2413-9.PMID: 11015466 [PubMed - indexed for MEDLINE]Related articlesFree article

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity.

Thupari JN, Landree LE, Ronnett GV, Kuhajda FP.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. Epub 2002 Jun 11.PMID: 12060712 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides.

Shimokawa T, Kumar MV, Lane MD.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):66-71. Epub 2001 Dec 26.PMID: 11756683 [PubMed - indexed for MEDLINE]Related articlesFree article