PubMed

Role of the ENPP1 K121Q polymorphism in glucose homeostasis.

Baratta R, Rossetti P, Prudente S, Barbetti F, Sudano D, Nigro A, Farina MG, Pellegrini F, Trischitta V, Frittitta L.

Diabetes. 2008 Dec;57(12):3360-4. Epub 2008 Sep 5.PMID: 18776139 [PubMed - indexed for MEDLINE]Related articlesFree article

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites.

Prudente S, Chandalia M, Morini E, Baratta R, Dallapiccola B, Abate N, Frittitta L, Trischitta V.

Obesity (Silver Spring). 2007 Jan;15(1):1-4.PMID: 17228024 [PubMed - indexed for MEDLINE]Related articles

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.

Grarup N, Urhammer SA, Ek J, Albrechtsen A, Glümer C, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O.

Diabetologia. 2006 Sep;49(9):2097-104. Epub 2006 Jul 25.PMID: 16865358 [PubMed - indexed for MEDLINE]Related articles

ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children.

Böttcher Y, Körner A, Reinehr T, Enigk B, Kiess W, Stumvoll M, Kovacs P.

J Clin Endocrinol Metab. 2006 Dec;91(12):4948-52. Epub 2006 Sep 12.PMID: 16968801 [PubMed - indexed for MEDLINE]Related articlesFree article

ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells.

Bacci S, Di Paola R, Menzaghi C, Di Fulvio P, Di Silvestre S, Pellegrini F, Baratta R, Marucci A, Mastroianno S, Fini G, Formoso G, Consoli A, Perticone F, Frittitta L, Pandolfi A, Trischitta V.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1678-83. Epub 2009 Aug 13.PMID: 19679831 [PubMed - indexed for MEDLINE]Related articles

Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene.

Wan C, Zhang T, Wang B, Han Y, Zhang C, Zhang Y, Gong H, Jin F, Wang L.

Diabetes Obes Metab. 2006 Nov;8(6):703-8.PMID: 17026496 [PubMed - indexed for MEDLINE]Related articles

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.

De Cosmo S, Minenna A, Zhang YY, Thompson R, Miscio G, Vedovato M, Rauseo A, Saller A, Mastroianno S, Pellegrini F, Trevisan R, Fioretto P, Doria A, Trischitta V.

Am J Kidney Dis. 2009 Feb;53(2):273-80. Epub 2008 Oct 31.PMID: 18950909 [PubMed - indexed for MEDLINE]Related articles

The role of K121Q ENPP1 polymorphism in diabetes mellitus and its complications.

Leitão CB, Nabinger GB, Krahe AL, Bolson PB, Gerchman F, Friedman R, Gross JL, Canani LH.

Braz J Med Biol Res. 2008 Mar;41(3):229-34. Epub 2007 Dec 20.PMID: 18176722 [PubMed - indexed for MEDLINE]Related articlesFree article

Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white children.

Morrison JA, Gruppo R, Glueck CJ, Stroop D, Fontaine RN, Wang P, Smith KL.

Metabolism. 2004 Apr;53(4):465-8.PMID: 15045693 [PubMed - indexed for MEDLINE]Related articles

Effect of the rs997509 polymorphism on the association between ectonucleotide pyrophosphatase phosphodiesterase 1 and metabolic syndrome and impaired glucose tolerance in childhood obesity.

Santoro N, Cirillo G, Lepore MG, Palma A, Amato A, Savarese P, Marzuillo P, Grandone A, Perrone L, Del Giudice EM.

J Clin Endocrinol Metab. 2009 Jan;94(1):300-5. Epub 2008 Oct 21.PMID: 18940878 [PubMed - indexed for MEDLINE]Related articles

Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population.

El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M.

Diabetes Metab. 2009 Feb;35(1):37-42. Epub 2008 Nov 28.PMID: 19046915 [PubMed - indexed for MEDLINE]Related articles

The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population.

Morandi A, Pinelli L, Petrone A, Vatin V, Buzzetti R, Froguel P, Meyre D.

Obesity (Silver Spring). 2009 Jan;17(1):202-6. Epub 2008 Oct 23.PMID: 18948963 [PubMed - indexed for MEDLINE]Related articles

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.

McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC; ENPP1 Consortium.

Diabetes. 2008 Apr;57(4):1125-30. Epub 2007 Dec 10.PMID: 18071025 [PubMed - indexed for MEDLINE]Related articlesFree article

The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.

Rasmussen SK, Urhammer SA, Pizzuti A, Echwald SM, Ekstrøm CT, Hansen L, Hansen T, Borch-Johnsen K, Frittitta L, Trischitta V, Pedersen O.

Diabetes. 2000 Sep;49(9):1608-11.PMID: 10969849 [PubMed - indexed for MEDLINE]Related articlesFree article

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.

Pizzuti A, Frittitta L, Argiolas A, Baratta R, Goldfine ID, Bozzali M, Ercolino T, Scarlato G, Iacoviello L, Vigneri R, Tassi V, Trischitta V.

Diabetes. 1999 Sep;48(9):1881-4.PMID: 10480624 [PubMed - indexed for MEDLINE]Related articlesFree article

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.

Kubaszek A, Pihlajamäki J, Karhapää P, Vauhkonen I, Laakso M.

Diabetes Care. 2003 Feb;26(2):464-7.PMID: 12547881 [PubMed - indexed for MEDLINE]Related articlesFree article

The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes.

Hamaguchi K, Terao H, Kusuda Y, Yamashita T, Hazoury Bahles JA, Cruz LL M, Brugal V LI, Jongchong W B, Yoshimatsu H, Sakata T.

J Clin Endocrinol Metab. 2004 Mar;89(3):1359-64.PMID: 15001634 [PubMed - indexed for MEDLINE]Related articlesFree article

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.

Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC.

Diabetes. 2008 Jul;57(7):1971-7. Epub 2008 Apr 21.PMID: 18426862 [PubMed - indexed for MEDLINE]Related articlesFree article

The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance.

Frittitta L, Baratta R, Spampinato D, Di Paola R, Pizzuti A, Vigneri R, Trischitta V.

J Clin Endocrinol Metab. 2001 Dec;86(12):5888-91.PMID: 11739459 [PubMed - indexed for MEDLINE]Related articlesFree article

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.

Weedon MN, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2006 Nov;55(11):3175-9.PMID: 17065358 [PubMed - indexed for MEDLINE]Related articlesFree article